30 research outputs found
Team 2: Situation Awareness of an Infantry Unit in a Chemical Environment
from Scythe : Proceedings and Bulletin of the International Data Farming Community, Issue 2 Workshop 14The German Federal Office of Defense Technology and
Procurement has been analyzing the influence of
networked sensors and effectors on military
capabilities. The background of our overall scenario is
peace support operations (PSO) in an urban
environment. The background for the actual technical
evaluations of sensors, effectors and the connecting
network is the following scenario vignette: Convoy
Protection
Identification of motifs that function in the splicing of non-canonical introns
The enrichment of specific intronic splicing enhancers upstream of weak PY tracts suggests a novel mechanism for intron recognition that compensates for a weakened canonical pre-mRNA splicing motif
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Idaho National Engineering and Environmental Laboratory Site Report on the Production and Use of Recycled Uranium
Recent allegations regarding radiation exposure to radionuclides present in recycled uranium sent to the gaseous diffusion plants prompted the Department of Energy to undertake a system-wide study of recycled uranium. Of particular interest, were the flowpaths from site to site operations and facilities in which exposure to plutonium, neptunium and technetium could occur, and to the workers that could receive a significant radiation dose from handling recycled uranium. The Idaho National Engineering and Environmental Laboratory site report is primarily concerned with two locations. Recycled uranium was produced at the Idaho Chemical Processing Plant where highly enriched uranium was recovered from spent fuel. The other facility is the Specific Manufacturing Facility (SMC) where recycled, depleted uranium is manufactured into shapes for use by their customer. The SMC is a manufacturing facility that uses depleted uranium metal as a raw material that is then rolled and cut into shapes. There are no chemical processes that might concentrate any of the radioactive contaminant species. Recyclable depleted uranium from the SMC facility is sent to a private metallurgical facility for recasting. Analyses on the recast billets indicate that there is no change in the concentrations of transuranics as a result of the recasting process. The Idaho Chemical Processing Plant was built to recover high-enriched uranium from spent nuclear fuel from test reactors. The facility processed diverse types of fuel which required uniquely different fuel dissolution processes. The dissolved fuel was passed through three cycles of solvent extraction which resulted in a concentrated uranyl nitrate product. For the first half of the operating period, the uranium was shipped as the concentrated solution. For the second half of the operating period the uranium solution was thermally converted to granular, uranium trioxide solids. The dose reconstruction project has evaluated work exposure and exposure to the public as the result of normal operations and accidents that occurred at the INEEL. As a result of these studies, the maximum effective dose equivalent from site activities did not exceed seventeen percent of the natural background in Eastern Idaho. There was no year in which the radiation dose to the public exceeded the applicable limits for that year. Worker exposure to recycled uranium was minimized by engineering features that reduced the possibility of direct exposure
Precision medicine trials.
<p>Our proposed clinical trial framework for precision medicine consists of selecting a data collection, processing and model-based decision-making protocol, then testing the entire joint protocol in a classical trial setting.</p
Physiological random processes in precision cancer therapy
<div><p>Many different physiological processes affect the growth of malignant lesions and their response to therapy. Each of these processes is spatially and genetically heterogeneous; dynamically evolving in time; controlled by many other physiological processes, and intrinsically random and unpredictable. The objective of this paper is to show that all of these properties of cancer physiology can be treated in a unified, mathematically rigorous way via the theory of random processes. We treat each physiological process as a random function of position and time within a tumor, defining the joint statistics of such functions via the infinite-dimensional characteristic functional. The theory is illustrated by analyzing several models of drug delivery and response of a tumor to therapy. To apply the methodology to precision cancer therapy, we use maximum-likelihood estimation with Emission Computed Tomography (ECT) data to estimate unknown patient-specific physiological parameters, ultimately demonstrating how to predict the probability of tumor control for an individual patient undergoing a proposed therapeutic regimen.</p></div
Reactivity measurements in the ETR critical facility /
"Reactors-General ; TID-4500, (13th Ed., Rev.)"--Cover."July 10, 1958"--Cover.Caption title.Includes bibliographical references (leaf 21).Work Performed by Phillips Petroleum Company for the Atomic Energy CommissionMode of access: Internet
TOC curves.
<p>An illustration of a Therapy Operating Characteristic (TOC) curve. (a) Schematic plot of Tumor-Control Probability (TCP) and Normal-Tissue-Complication Probability (NTCP) vs. injected mass of drug, <i>M</i> (arbitrary units); (b) The TOC curve: Plot of TCP vs. NTCP as <i>M</i> is varied.</p