Illustration of the 21 bp insertion/deletion polymorphism (long and short alleles) and the insertion/deletion GG allele in the gene

<p><b>Copyright information:</b></p><p>Taken from "Sequence variation and linkage disequilibrium in the GABA transporter-1 gene () in five populations: implications for pharmacogenetic research"</p><p>http://www.biomedcentral.com/1471-2156/8/71</p><p>BMC Genetics 2007;8():71-71.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2175509.</p><p></p> Picture (A) shows position of -24794 A/G SNP, 21 bp insertion and GG deletion. Picture (B) shows the sequence for the short and long alleles and the -24794 A/G SNP. The A allele of the -24794 always coincided with the long allele in our populations. Sequence for the GG insertion/deletion polymorphism is presented in picture (C)

Illustration of the LD structure and recombination hotspots in the 5 populations

<p><b>Copyright information:</b></p><p>Taken from "Sequence variation and linkage disequilibrium in the GABA transporter-1 gene () in five populations: implications for pharmacogenetic research"</p><p>http://www.biomedcentral.com/1471-2156/8/71</p><p>BMC Genetics 2007;8():71-71.</p><p>Published online 17 Oct 2007</p><p>PMCID:PMC2175509.</p><p></p> Upper graphs illustrate elevations from the background recombination rates across the gene. Y axis represent recombination rate and X axis represents physical distance between the markers [19, 20]. In Figure A, recombination rates for HapMap CEPH Western Europeans (CEU) and European-Americans of the present study are presented. In Figure B, recombination rates for HapMap Yoruban (YRI) and African-Americans of the present study are presented. In Figure C, recombination rates for HapMap combined Han Chinese and Japanese populations (HCB+JPT) and the Thais of the present study are presented. In Figures D and E, recombination rates for the Finns and Hmongs of the present study are presented. In the middle, the exon-intron structure of and location of the markers is presented. LD (D') between the SNPs in is illustrated in the lower triangular graphs