Active Co-prevalent and incident TB among contacts by age, gender and their index cases' characteristics, Tbilisi, Georgia, 2010–2011.

1<p>index cases>17 years of age.</p><p><b>Abbreviations</b>: AFB – Acid-fast bacilli; SS – sputum smear; MDR – Multidrug-resistant.</p><p>Active Co-prevalent and incident TB among contacts by age, gender and their index cases' characteristics, Tbilisi, Georgia, 2010–2011.</p

Active incident TB among contacts by age, gender and their index cases' characteristics, Tbilisi, Georgia, 2010–2011.

1<p>index cases>17 years of age.</p><p><b>Abbreviations</b>: AFB – Acid-fast bacilli; SS – sputum smear; MDR – Multidrug-resistant.</p><p>Active incident TB among contacts by age, gender and their index cases' characteristics, Tbilisi, Georgia, 2010–2011.</p

Multivariate analysis for latent tuberculosis infection (LTBI) diagnostic test (QFT-GIT and TST) conversion.

<p>Frequent contact is contact with TB patients ≥ twice per month</p><p>Rare contact is contact with TB patients < twice per month.</p

Contact investigation study flow, Tbilisi, Georgia, 2010–2011.

<p>Contact investigation study flow, Tbilisi, Georgia, 2010–2011.</p

Enrollment and follow-up of participants.

<p>HCW: healthcare workers, QFT-GIT  =  QuantiFERON-TB Gold In-tube assay, TST = tuberculin skin test.</p

Socio-demographic and clinical characteristics of index tuberculosis (TB) cases, Tbilisi, Georgia, 2010–2011.

1<p>index cases>17 years of age.</p><p><b>Abbreviations:</b> AFB–Acid-fast bacilli; SS–sputum smear; MDR–Multidrug-resistant</p><p>Socio-demographic and clinical characteristics of index tuberculosis (TB) cases, Tbilisi, Georgia, 2010–2011.</p

Active TB disease among contacts, Tbilisi, Georgia, 2010–2011.

<p>Active TB disease among contacts, Tbilisi, Georgia, 2010–2011.</p

Results of Diagnostic tests for Latent TB Infection among Healthcare Workers (HCWs) who underwent serial testing: Conversions and Reversions.

<p>HCW: healthcare workers, QFT-GIT  =  QuantiFERON-TB Gold In-tube assay, TST  =  tuberculin skin test.</p

Model parameters, base case and reasonable ranges.

<p>AFB = Acid fast bacillus; AII = airborne infection isolation; GMH = Grady Memorial Hospital, Atlanta, GA, USA; NAAT = nucleic acid amplification test; PPV = positive predictive value; TB = tuberculosis</p><p>*Base case was determined by multiplying charge by cost/charge ratio.</p><p>∧This upper bound was determined in the cited publication by considering all aspects of outpatient care in calculating treatment cost and was included for sensitivity analyses.</p>†<p>We could not find estimates of exposure investigation cost in the literature, so for sensitivity analyses we took the extreme position of varying the cost from one tenth to 100 times the base case cost (for low and high bounds, respectively).</p>‡<p>TB prevalence among patients in our study population, i.e. those with an AFB smear-positive sputum sample. This is equivalent to the PPV of AFB smear microscopy.</p><p>#The TB prevalence among AFB smear positives in our study (i.e. PPV of AFB smear) was lower than any found in the literature. For lower bound of TB prevalence we used PPV among HIV patients in our study, i.e. as if all AFB smear-positive patients had HIV.</p

Demographic information for healthcare workers (n = 319).

<p>Demographic information for healthcare workers (n = 319).</p