5,414 research outputs found
High-Q Silicon Resonators For High-Coherence Hybrid Si/III-V Semiconductor Lasers
We report on the design and experimental demonstration of high-Q Si resonators with Q ~ 10^6, a fundamental figure of merit of the phase coherence of hybrid Si/III-V semiconductor lasers
Childrenâs Early Awareness of Comprehension as Evident in Their Spontaneous Corrections of Speech Errors
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147836/1/cdev12862_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147836/2/cdev12862.pd
The Solar Neighborhood. XXVI. AP Col: The Closest (8.4 pc) Pre-Main-Sequence Star
We present the results of a multi-technique investigation of the M4.5Ve flare
star AP Col, which we discover to be the nearest pre-main-sequence star. These
include astrometric data from the CTIO 0.9m, from which we derive a proper
motion of 342.0+/-0.5 mas yr^-1, a trigonometric parallax of 119.21+/-0.98 mas
(8.39+/-0.07 pc), and photometry and photometric variability at optical
wavelengths. We also provide spectroscopic data, including radial velocity
(22.4+/-0.3 km s^-1), lithium Equivalent Width (EW) (0.28+/-0.02 A), H-alpha EW
(-6.0 to -35 A), {\it vsini} (11+/-1 km s^-1), and gravity indicators from the
Siding Spring 2.3-m WiFeS, Lick 3-m Hamilton echelle, and Keck-I HIRES echelle
spectrographs. The combined observations demonstrate that AP Col is the closer
of only two known systems within 10 pc of the Sun younger than 100 Myr. Given
its space motion and apparent age of 12-50 Myr, AP Col is likely a member of
the recently proposed ~40 Myr old Argus/IC 2391 association.Comment: 31 pages, 11 figure
Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus
Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice only. This study investigates how age affects cartilage and subchondral bone changes in mouse joints following DMM. DMM was performed on male C57BL/6 mice at 4 months (4 M), 12 months (12 M) and 19+ months (19 M+) and on females at 12 M and 18 M+. Two months after surgery, operated and unoperated contralateral knees were harvested and evaluated using cartilage histology scores and muCT quantification of subchondral bone plate thickness and osteophyte formation. The 12 M and 19 M+ male mice developed more cartilage erosions and thicker subchondral bone plates after DMM than 4 M males. The size of osteophytes trended up with age, while the bone volume fraction was significantly higher in the 19 M+ group. Furthermore, 12 M females developed milder OA than males as indicated by less cartilage degradation, less subchondral bone plate sclerosis and smaller osteophytes. Our results reveal distinct age/gender-dependent structural changes in joint cartilage and subchondral bone post-DMM, facilitating more thoughtful selection of murine age/gender when using this surgical technique for translational OA research
Browser State Repository Service
We introduce browser state repository (BSR) service that allows a user to save and restore multiple independent snapshots of web sessions on a browser. At a later time, the user can retrieve any saved snapshot on a potentially different browser on a different device to continue any one of the chosen saved session in any order. The web session snapshot captures a complete browser running state, including the last page that appears on the browser, document object state, script state, values that a user enters in forms on the last page, browser history for back and forward pages, and cookies. BSR service consists of a browser plug-in that takes browser session snapshots, and a repository server that stores snapshots securely for each user. The main contribution of BSR service is that it decouples association between browser state and a device, in favor of association between browser state and its user
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Four Dimensional MR Image Analysis of Dynamic Renography
A novel four dimensional image analysis approach including registration and segmentation of dynamic contrast enhanced renal MR images is presented. This integrated method is motivated by the observation of the reciprocity between registration and segmentation in 4D time-series images. Fully automated Fourier-based registration with sub-voxel accuracy and semi-automated time-series segmentation were intertwined to improve the accuracy in a multi-step fashion. We have tested our algorithm on several real patient data sets. Clinical validation showed remarkable and consistent agreement between the proposed method and manual segmentation by experts
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Automatic 4-D Registration in Dynamic MR Renography
Dynamic contrast-enhanced 4-D MR renography has the potential for broad clinical applications, but suffers from respiratory motion that limits analysis and interpretation. Since each examination yields at least over 10 20 serial 3-D images of the abdomen, manual registration is prohibitively labor-intensive. Besides in-plane motion and translation, out-of-plane motion and rotation are observed in the image series. In this paper, a novel robust and automated technique for removing out-of-plane translation and rotation with sub-voxel accuracy in 4-D dynamic MR images is presented. The method was evaluated on simulated motion data derived directly from a clinical patient's data. The method was also tested on 24 clinical patient kidney data sets. Registration results were compared with a mutual information method, in which differences between manually co-registered time-intensity curves and tested time-intensity curves were compared. Evaluation results showed that our method agreed well with these ground truth data
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