Baseline characteristics of the study population.

<p>Baseline characteristics of the study population.</p

Incidence rate ratio of Alzheimer's disease, vascular dementia, all dementia combined by ABO blood groups stratified according to attained age.

<p>IRR* and IRR** denotes adjusted incidence rate ratio. IRR (95%CI) represents incident rate ratio and 95% confidence interval and were estimated using Poisson regression adjusted for country, sex, attained age, calendar period of observation and the interaction between country and calendar period of observation for adjusted model-1*. In adjusted model-2**, the model included additional adjustments for diabetes, stroke and myocardial infarction. Analyses were restricted to subjects with known blood group who were born in Sweden or Denmark. Blood group O is the reference category.</p><p>Incidence rate ratio of Alzheimer's disease, vascular dementia, all dementia combined by ABO blood groups stratified according to attained age.</p

Uni-and multivariate cox regression.

<p>The analysis only included subjects with complete data (N = 90).</p><p>HR: hazard ratio, CI: confidence interval, %: proportion of total CD4 or CD8 cells respectively.</p><p>Subsets were defined as naïve CD4/8(CD45RA+, CD62+), memory CD4/8 (CD45RA-, CD45R0+), activated CD4 (HLA-DR+), and activated CD8 (HLA-DR+, CD38+).</p

Levels of β2-microglobulin, IL-8, TNFα, sICAM-1, sVCAM-1 and sE-Selectin in HIV infected patients (HIV+) after 12 years of successful cART compared to HIV negative controls.

<p>Please note that β2-microglobulin is shown on a logarithmic Y-axis. Means were compared using Mann-Whitney test and depicted as boxplots with Tukey whiskers (1.5 times the interquartile distance or to the highest or lowest point, whichever is shorter). * = p<0.05, ** = p<0.001.</p

Kaplan-Meier plots.

<p>The observation period (days) is from 18 months (+/−6 months) after initiation of cART till death or 01/01/2010. The dotted line depicts the highest 50^th percentile and the full line depicts the lowest 50^th percentile. Analysis of survival linked to T cell subset are made with proportions of CD4+ and CD8+ cells respectively. Analysis using concentrations instead of proportions yielded similar results. Subsets were defined as naïve CD4/8(CD45RA+, CD62+), memory CD4/8 (CD45RA-, CD45R0+) and activated CD4 (HLA-DR+), and activated CD8 (HLA-DR+, CD38+).</p

Soluble urokinase plasminogen activator receptor (suPAR) (ng/ml) in blood donors according to sex and age.

<p>Soluble urokinase plasminogen activator receptor (suPAR) (ng/ml) in blood donors according to sex and age.</p

Risk of an incident hospital diagnosis of depression according to the suPAR level.

<p>Risk of an incident hospital diagnosis of depression according to the suPAR level.</p

Kaplan-Meier plot with antidepressants as outcome and the suPAR level quartiles as explanatory variables (n = 9305).

<p>The 4^th quartile is the highest values. Log-rank test: p<0.0001.</p

Effect¹ of previous use of antidepressants on log2-transformed suPAR.

1<p>Estimates are from linear regressions adjusting for age (continuous).</p><p>Effect^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110555#nt102" target="_blank">1</a>} of previous use of antidepressants on log2-transformed suPAR.</p

Risk¹ of incident use of antidepressants according to the suPAR level.

1<p>Estimates are hazard ratios from Cox regression analyses stratified by sex and with age as the underlying time scale. Purchase of antidepressants is used as proxy for depression. The analysis is performed both with and without adjustment for other medication.</p><p>Risk^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110555#nt101" target="_blank">1</a>} of incident use of antidepressants according to the suPAR level.</p