Time from approval to publication of completed academic drug randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs).

<p>Time from approval to publication of completed academic drug randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs).</p

Reasons for non-initiation, non-completion, and non-publication of academic drug trials.

<p>Reasons for non-initiation, non-completion, and non-publication of academic drug trials.</p

Time from approval to publication of completed academic drug trials.

<p>(n = 114).</p

Number and proportion of initiated, completed, and published academic drug trials by year of approval of clinical trial application.

<p>Number and proportion of initiated, completed, and published academic drug trials by year of approval of clinical trial application.</p

Characteristics of included academic drug trials by publication status.

<p>Characteristics of included academic drug trials by publication status.</p

Antidepressants included in the study.

<p>Table shows the generic names and their corresponding ATC codes for antidepressants included in the present study. SSRI: Selective Serotonine Reuptake Inhibitor; TCA: Tri Cyclic Antidepressant (Non-selective Monoamine Reuptake Inhibitor).</p

Pre-pregnancy treatment-naïve women exposed to an antidepressant.

<p>Number of pre-pregnancy treatment-naive women exposed to an antidepressant during and after pregnancy. Number in parenthesis is the percentage of ‘any antidepressant’. Sum of percentages adds up to more than 100% due to some pregnancies being exposed to more than one antidepressant in the given period. SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressants; AD, antidepressant.</p

Number of women exposed to an antidepressant during pregnancy.

<p>Number in parenthesis is the percentage of ‘any antidepressant’. Sum of percentages adds up to more than 100% due to some pregnancies being exposed to more than one antidepressant in the given period. SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressants; AD, antidepressant.</p

Percentage of pregnant women in treatment with an antidepressant for each day from 180 days before conception to 630 days after conception (approximately 1 year after mean time of delivery).

<p>The figure is divided into three areas of different color indicating the period of treatment start; before (dark blue), during (blue) or after pregnancy (light blue).</p

Point prevalence of pregnant women in treatment with an antidepressant based on estimated treatment periods.

<p>SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressants; AD, antidepressant.</p