Low-FODMAP-Diät – Lösung aller Probleme?

Das Thema Ernährung ist für Patienten mit einem Reizdarmsyndrom hochrelevant, da Nahrungsmittel als symptomauslösend empfunden werden. Die Abkürzung FODMAP steht für „fermentierbare Oligosaccharide, Disaccharide, Monosaccharide und Polyole“, also kurzkettige Kohlenhydrate, die im Dünndarm schlecht absorbiert werden und durch Fermentationsprozesse Blähungen und Stuhlunregelmässigkeiten hervorrufen können. Die FODMAP-Diät ist bei Reizdarmsyndrom(RDS)-Patienten zur Symptomkontrolle effektiv und verläuft in 3 Phasen (Reduktion – Reexposition – Personalisierung) und sollte von einer geschulten Ernährungsberatung in enger Zusammenarbeit mit dem behandelnden Gastroenterologen/in erfolgen um eine Fehl- oder Mangelernährung zu vermeiden

Over-the-scope-clip closure of long lasting gastrocutaneous fistula after percutaneous endoscopic gastrostomy tube removal in immunocompromised patients: A single center case series

Over-the-scope-clips (OTSC(®)) have been shown to be an effective and safe endoscopic treatment option for the closure of gastrointestinal perforations, leakages and fistulae. Indications for endoscopic OTSC(®) treatment have grown in number and also include gastro cutaneous fistula (GCF) after percutaneous endoscopic gastrostomy (PEG) tube removal. Non-healing GCF is a rare complication after removal of PEG tubes and may especially develop in immunosuppressed patients with multiple comorbidities. There is growing evidence in the literature that OTSC(®) closure of GCF after PEG tube removal is emerging as an effective, simple and safe endoscopic treatment option. However current evidence is limited to the geriatric population and short standing GCF, while information on closure of long standing GCF after PEG tube removal in a younger population with significant comorbidities is lacking. In this retrospective single-center case-series we report on five patients undergoing OTSC(®) closure of chronic GCF after PEG tube removal. Four out of five patients were afflicted with long lasting, symptomatic fistulae. All five patients suffered from chronic disease associated with a catabolic metabolism (cystic fibrosis, chemotherapy for neoplasia, liver cirrhosis). The mean patient age was 43 years. The mean dwell time of PEG tubes in all five patients was 808 d. PEG tube dwell time was shortest in patient 5 (21 d). The mean duration from PEG tube removal to fistula closure in patients 1-4 was 360 d (range 144-850 d). The intervention was well tolerated by all patients and no adverse events occured. Successful immediate and long-term fistula closure was accomplished in all five patients. This single center case series is the first to show successful endoscopic OTSC(®) closure of long lasting GCF in five consecutive middle-aged patients with significant comorbidities. Endoscopic closure of chronic persistent GCF after PEG tube removal using an OTSC(®) was achieved in all patients with no immediate or long-term complications. OTSC(®) is a promising endoscopic treatment option for this condition with a potentially high immediate and long term success rate in patients with multiple comorbidities

Ökonomische Bewertung von typischen Nährstoffmanagement-Systemen im ökologischen Gemüsebau

Basierend auf Interviews mit Betriebsleiter*innen ökologischer Gemüsebaubetriebe, wurden Modelle typischer Nährstoffmanagement-Systeme für Betriebe unterschiedlicher Produktionsausrichtung entwickelt und hinsichtlich der Hauptnährstoffquellen, Höhe der Nährstoffzufuhren und Kosten verglichen

UEG Young Talent Group : What do we do?

publishersversio

Impact of Vedolizumab on Extraintestinal Manifestations in Inflammatory Bowel Disease: Results From a Descriptive, Retrospective, Real-world Study

BACKGROUND Patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, may develop extraintestinal manifestations (EIMs). The EMOTIVE study aimed to analyze the effect of vedolizumab on EIMs in a real-world cohort of patients with IBD. METHODS This multicenter, descriptive, retrospective study was conducted in Belgium, Denmark, Israel, the Netherlands, and Switzerland in adults with moderately to severely active IBD and concurrent active EIMs at vedolizumab initiation (index date), with a ≥6-month follow-up after the index date. The primary endpoint was resolution of all EIMs within 6 months of vedolizumab initiation. RESULTS In 99 eligible patients, the most frequent EIMs were arthralgia (69.7%), peripheral spondyloarthritis (21.2%), and axial spondyloarthritis (10.1%). Within 6 and 12 months of vedolizumab initiation, 19.2% and 25.3% of patients reported resolution of all EIMs, while 36.5% and 49.5% of all EIMs were reported to be improved (combination of resolution and partial response), respectively. Vedolizumab treatment persistence at 12 months was 82.8%. Adverse events were reported in 18.2% of patients, with the most frequent being arthralgia (4.0%). CONCLUSIONS This real-world study showed resolution of all EIMs in up to one-fourth of patients with IBD and improvement in up to half of EIMs within 12 months of vedolizumab treatment. Overall, vedolizumab was effective on EIMs in patients with IBD and showed a good safety profile

Reference intervals for selected serum biochemistry analytes in cheetahs (Acinonyx jubatus)

Published haematologic and serum biochemistry reference intervals are very scarce for captive cheetahs and even more for free-ranging cheetahs. The current study was performed to establish reference intervals for selected serum biochemistry analytes in cheetahs. Baseline serum biochemistry analytes were analysed from 66 healthy Namibian cheetahs. Samples were collected from 30 captive cheetahs at the AfriCat Foundation and 36 free-ranging cheetahs from central Namibia. The effects of captivity-status, age, sex and haemolysis score on the tested serum analytes were investigated. The biochemistry analytes that were measured were sodium, potassium, magnesium, chloride, urea and creatinine. The 90% confidence interval of the reference limits was obtained using the non-parametric bootstrap method. Reference intervals were preferentially determined by the non-parametric method and were as follows: sodium (128 mmol/L – 166 mmol/L), potassium (3.9 mmol/L – 5.2 mmol/L), magnesium (0.8 mmol/L – 1.2 mmol/L), chloride (97 mmol/L – 130 mmol/L), urea (8.2 mmol/L – 25.1 mmol/L) and creatinine (88 μmol/L – 288 μmol/L). Reference intervals from the current study were compared with International Species Information System values for cheetahs and found to be narrower. Moreover, age, sex and haemolysis score had no significant effect on the serum analytes in this study. Separate reference intervals for captive and free-ranging cheetahs were also determined. Captive cheetahs had higher urea values, most likely due to dietary factors. This study is the first to establish reference intervals for serum biochemistry analytes in cheetahs according to international guidelines. These results can be used for future health and disease assessments in both captive and free- ranging cheetahs.The South African Veterinary Foundation (SAVF), the Wildlife Group of the South African Veterinary Association (SAVA), the Messerli Foundation in Switzerland and the Research Committee of the University of Pretoria.http://www.jsava.co.zaam2016Companion Animal Clinical Studie

Alternde Gesellschaften in Europa. Empirische Untersuchungen mit Daten des SHARE

Dieser Band präsentiert drei ausgewählte empirische Studien, die im Rahmen des Bevölkerungswissenschaftlichen Forschungspraktikums an der Universität Bamberg entstanden sind. Der erste Beitrag beschäftigt sich mit „familialen Transferregimes“ in Europa, dem privaten Äquivalent zu öffentlichen Wohlfahrtsstaatsregimes. Im Mittelpunkt der Analyse steht die Frage, ob und wie sich osteuropäische Länder von nord-, west- und südeuropäischen Regimetypen unterscheiden. Der zweite Beitrag untersucht, ob sich ältere Menschen nach dem Renteneintritt gleichbleibend, vermehrt oder seltener ehrenamtlich engagieren. Der dritte Beitrag konzentriert sich ebenfalls auf die Effekte des Renteneintritts. Diese Arbeit geht der Frage nach, ob die Verrentung für ältere Menschen ein stressauslösendes Ereignis ist, das den gesundheitlichen Abbau beschleunigt. Die Autorinnen und Autoren untersuchen diese aktuellen sozialwissenschaftlichen Fragestellungen mit Daten der ersten beiden Wellen des Survey of Health, Ageing and Retirement in Europe (SHARE)