Genotype distribution in patients with gastrointestinal cancer and controls.

<p>*Note that some patients or controls are missing because of failure of the genotyping.</p><p>**Adjusted for age.</p><p>GI, gastrointestinal; OR, odds ratio; CI, confidence interval.</p

Associations of the SNPs rs6214 and rs6898743 with gastrointestinal cancer.

<p>Only significant associations are visualized. Associations are given as follows: rs number of the SNP, genotype, odds ratio with corresponding 95% confidence interval. The homozygous most common genotype is taken as reference. EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma.</p

Genotype distribution and ORs (95% CI) for the genotypes of SNPs rs6214 and rs6898743 in patients with EAC, ESCC, proximal CRC or distal CRC.

<p>EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; CRC, colorectal cancer.</p

cytokine production in healthy controls versus patients with quiescent CD.

<p>Cytokine levels (pg/ml) are presented as medians with the interquartile range [IQR]. TNF-α, Tumor necrosis factor alpha; IL, Interleukin; IQR, interquartile range; CD, Crohn's disease.</p><p>cytokine production in healthy controls versus patients with quiescent CD.</p

Primer sequences and conditions for the TNF-α promoter gene.

<p>Mg_: Magnesium concentration.</p><p>Primer sequences and conditions for the TNF-α promoter gene.</p

Characteristics of the study population.

<p>n = number of patients or controls; GI, gastrointestinal; SD = standard deviation; EAC = esophageal adenocarcinoma; ESCC = esophageal squamous cell carcinoma;</p>1<p><i>p</i>-value mean age = 0.000;</p>2<p><i>p</i>-value mean age = 0.001.</p

Sequences of primers and probes, including the optimal annealing temperature and MgCl₂-concentration.

<p>F = forward; R = reverse; WT = wild type; VAR = variant; the bold underlined letters represent the wild type (most common) allele (Allele 1) and the variant allele (Allele 2) in the WT probe and VAR probe, respectively.</p

Cytokine production and disease characteristics.

<p>Cytokine levels (pg/ml) are presented as medians with the interquartile range [IQR]. HC, Healthy control; TNF-α, Tumor necrosis factor alpha; IL, Interleukin; L1, ileal disease; L2, colonic disease; L3, ileocolonic disease; P-, no peri-anal disease; P+, peri-anal disease; IQR, interquartile range.</p><p>Cytokine production and disease characteristics.</p

Relation between cytokine production and disease severity.

<p>Values are presented as medians (pg/ml) with the interquartile range. For the number of bowel resections and treatment exposure patients were dichotomized in a low and high group according to the number of resections or the percentage of years in which they were treated with steroids, thiopurines, biologicals, methotrexate or cyclosporine, corrected for disease duration. Two patients were excluded for the analysis for treatment exposure, because no complete drug history was available. TNF-α, Tumor necrosis factor alpha; IL, Interleukin; L1, ileal disease; L3, ileocolonic disease; P-, no fistulas; P+, fistulating disease.</p

Baseline characteristics of the included patients with CD and HC.

<p>CD, Crohn’s disease; HC, healthy controls; SD, standard deviation; 5-ASA, 5-aminosalicylic acid.</p><p>Baseline characteristics of the included patients with CD and HC.</p