Detail of intervention.

<p>Detail of intervention.</p

Forest plot for radiological fracture pain degree.

<p>Forest plot for radiological fracture pain degree.</p

Sensitivity analyses based on various exclusion criteria for functional outcome.

<p>Sensitivity analyses based on various exclusion criteria for functional outcome.</p

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis

<div><p>Purpose</p><p>Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn’t come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing.</p><p>Methods</p><p>We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing.</p><p>Results</p><p>Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain.</p><p>Conclusions</p><p>This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.</p></div

Forest plot for radiological fracture functional outcome.

<p>Forest plot for radiological fracture functional outcome.</p

Flow diagram of selection of studies.

<p>Flow diagram of selection of studies.</p

Adverse effects.

<p>Adverse effects.</p

Characteristics of included studies.

<p>Characteristics of included studies.</p

Sensitivity analyses based on various exclusion criteria for pain degree.

<p>Sensitivity analyses based on various exclusion criteria for pain degree.</p

Forest plot for radiological fracture healing rate.

<p>Forest plot for radiological fracture healing rate.</p