841 research outputs found
Impact of g-factors and valleys on spin qubits in a silicon double quantum dot
We define single electron spin qubits in a silicon MOS double quantum dot
system. By mapping the qubit resonance frequency as a function of gate-induced
electric field, the spectrum reveals an anticrossing that is consistent with an
inter-valley spin-orbit coupling. We fit the data from which we extract an
inter-valley coupling strength of 43 MHz. In addition, we observe a narrow
resonance near the primary qubit resonance when we operate the device in the
(1,1) charge configuration. The experimental data is consistent with a
simulation involving two weakly exchanged-coupled spins with a g-factor
difference of 1 MHz, of the same order as the Rabi frequency. We conclude that
the narrow resonance is the result of driven transitions between the T- and T+
triplet states, using an ESR signal of frequency located halfway between the
resonance frequencies of the two individual spins. The findings presented here
offer an alternative method of implementing two-qubit gates, of relevance to
the operation of larger scale spin qubit systems
Opto-PCB: Three demonstrators for optical interconnections
We report on a research project targeting optical waveguide integrated PCBs conducted within the European FP6
Network of Excellence on Micro-Optics NEMO. For three identified feature requests we have built three specific demonstrators
respectively addressing the integration of active components, the fabrication of peripheral fibre ribbons and the integration of
multiple layers of waveguides on the board
Local Leaders in Random Networks
We consider local leaders in random uncorrelated networks, i.e. nodes whose
degree is higher or equal than the degree of all of their neighbors. An
analytical expression is found for the probability of a node of degree to
be a local leader. This quantity is shown to exhibit a transition from a
situation where high degree nodes are local leaders to a situation where they
are not when the tail of the degree distribution behaves like the power-law
with . Theoretical results are verified by
computer simulations and the importance of finite-size effects is discussed.Comment: 4 pages, 2 figure
Defective complex I assembly due to C20orf7 mutations as a new cause of Leigh syndrome
Background: Leigh syndrome is an early onset, progressive, neurodegenerative disorder with developmental and motor skills regression. Characteristic magnetic resonance imaging abnormalities consist of focal bilateral lesions in the basal ganglia and/or the brainstem. The main cause is a deficiency in oxidative phosphorylation due to mutations in an mtDNA or nuclear oxidative phosphorylation gene. Methods and results: A consanguineous Moroccan family with Leigh syndrome comprise 11 children, three of which are affected. Marker analysis revealed a homozygous region of 11.5 Mb on chromosome 20, containing 111 genes. Eight possible mitochondrial candidate genes were sequenced. Patients were homozygous for an unclassified variant (p.P193L) in the cardiolipin synthase gene (CRLS1). As this variant was present in 20% of a Moroccan control population and enzyme activity was only reduced to 50%, this could not explain the rare clinical phenotype in our family. Patients were also homozygous for an amino acid substitution (p.L159F) in C20orf7, a new complex I assembly factor. Parents were heterozygous and unaffected sibs heterozygous or homozygous wild type. The mutation affects the predicted S-adenosylmethionine (SAM) dependent methyltransferase domain of C20orf7, possibly involved in methylation of NDUFB3 during the assembly process. Blue native gel electrophoresis showed an altered complex I assembly with only 30-40% of mature complex I present in patients and 70-90% in carriers. Conclusions: A new cause of Leigh syndrome can be a defect in early complex I assembly due to C20orf7 mutations
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