Shanghai, Dubai, Mumbai Or Goodbye?

Starting in 2007, Sovereign Wealth Funds (SWFs) from Asia and the Middle East have invested billions of dollars in major U.S. financial firms. The primary driving force behind their growth is rising commodity prices, in particular oil. Given that SWFs represent a relatively new, cash-rich investment group, we studied the public policy concerns with their investments, SWFs mode of entry, and how does the market react to the investment. SWFs lack of transparency with regards to their investment motives and governance structure is cause for concern. While taking full opportunity of depressed security prices as a result of the 2007-2008 financial crisis, they are also being prudent by investing mostly in preferred stocks and fixed-income convertible securities of large U.S. corporations that are followed by many analysts and are highly liquid. Despite investing handsomely in U.S. targets and adopting a hands-off approach toward management; the liquidity crisis continues to perpetuate the decline in SWF-targets’ stock price post-investment. Using an event study parameter approach, we found the short-run market reaction to be statistically insignificant in 11 out of 12 announcements of SWF investments; but in the months following the investment, SWF-targets underperform both the S&P500 and the Dow Jones Financial Services Index Fund.Stock Market, Sovereign Wealth Funds (SWFs), SWF-targets’ stock price post-investment

The innovation challenge: A blueprint for American competitiveness in the twenty‐first‐century global economy?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91140/1/21470_ftp.pd

Relationships between online gambling, mental health and substance use: A review

This review deals with the published literature to date while examining the relationship between online gambling, mental health problems, and substance use. Online gambling, particularly problematic gambling online, was found to be associated with poor mental health and use of various substances. Recent preliminary evidence also suggests that online gamblers may be at a greater risk of some substance use and mental health problems, relative to nononline gamblers. However, many of the reviewed studies were limited by investigation of online gambling behaviors only; these samples may have inadvertently comprised individuals who engage in both online and nononline gambling. Future research is required to address these limitations

Sovereign wealth funds: National security risks in a global free trade environment

The proliferation of sovereign wealth funds (SWFs) has resulted in an unstable political, legal, and regulatory environment for this form of foreign direct investment (FDI). This article explains SWF growth over the last half-century; discusses issues surrounding SWF “transparency” and host-country national security risk; reviews the legal and regulatory structures governing FDI in major national economies; examines proposed regulatory approaches to structure the FDI environment; and concludes with a discussion of SWF regulatory policy recommendations addressing corporate governance principles, national security restrictions on equity investment, and investment reciprocity, and suggests recommendations for executives considering engaging an SWF investment partner. © 2009 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64327/1/20299_ftp.pd

The Obama Administration's Regulatory Review Initiative: A 21st Century Federal Regulatory Initiative?

On January 18, 2011, President Obama signed Executive Order 13563, Improving Regulation and Regulatory Review, which instructs federal regulators to do the following: coordinate their agencies activities to simplify and harmonize rules that may be overlapping, inconsistent, or redundant; determine whether the present and future benefits of a proposed regulation justify its potential costs (including taking into account both quantitative and qualitative factors); increase participation of industry, experts, and the public (“stakeholders”) in the formal rule‐making process; encourage the use of warnings, default rules, disclosure requirements, and provisions of information to the public as an alternative to traditional “command‐and‐control” rule‐making restricting consumer choice; and mandate a government‐wide review of all existing administrative rules to remove outdated regulations. Executive Order 13563 includes a qualitative “values” provision to be considered in the required cost–benefit analysis, which can potentially counteract the alleged regulatory reform rationale of President Obama. Furthermore, in Executive Order 13563, President Obama established a deadline of May 18, 2011, for all executive branch agencies to submit their plans to streamline their rulemaking operations and repeal those “overlapping, inconsistent, or redundant” rules. These two issues, along with complementary regulatory review proposals being discussed in the U.S. Congress, are evaluated in this essay.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91369/1/j.1467-8594.2012.00404.x.pd

Obesity in America: A Market Failure?

Since the late 1980s, obesity in America has been a looming public health concern. Recently, medical researchers found that, for the 2011‐12 period, 35.3 percent of U.S. adults (aged 20 or older), 20.5 percent of teenagers (ages 12‐19), 17.7 percent of children (ages 6‐11), and 8.4 percent of young children (ages 2‐5) have obesity, and 6.3 percent of U.S. adults having severe obesity. In a recent working paper by Karnani, McFerran, and Mukhopadhyay (2015), these management scholars argue that obesity represents a market failure. In their study, Karnani et al. evaluate the effectiveness of corporate social responsibility, industry self‐regulation, social activism, and government regulation as to its effectiveness on consumer behavior and reducing obesity. Karnani et al. are advocates of “reasonable” government intervention, i.e., tax/subsidies, market regulation, and education, to address the public health issue of obesity. However, evidence shows that reasonable government intervention is also vulnerable to government failure and potential public health risk. Recommended is a mix of institutional activities found in corporate social responsibility, industry self‐regulation, social activism, and government intervention, all of which should provide the direction needed to continue this public health trend away from America’s epidemic levels of obesity.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146865/1/basr12157.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146865/2/basr12157_am.pd

Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options

Echinococcus granulosus and Echinococcus multilocularis are cestode parasites, of which the metacestode (larval) stages cause the neglected diseases cystic echinococcosis (CE) and alveolar echinococcosis (AE), respectively. The benzimidazoles albendazole and mebendazole are presently used for the chemotherapeutical treatment, alone or prior to and after surgery. However, in AE these benzimidazoles do not appear to be parasiticidal in vivo. In addition, failures in drug treatments as well as the occurrence of side-effects have been reported, leading to discontinuation of treatment or to progressive disease. Therefore, new drugs are needed to cure AE and CE. Strategies that are currently employed in order to identify novel chemotherapeutical treatment options include in vitro and in vivo testing of broad-spectrum anti-infective drugs or drugs that interfere with unlimited proliferation of cancer cells. The fact that the genome of E. multilocularis has recently been sequenced has opened other avenues, such as the selection of novel drugs that interfere with the parasite signalling machinery, and the application of in silico approaches by employing the Echinococcus genome information to search for suitable targets for compounds of known mode of actio

Social norms in the development of adolescent substance use: a longitudinal analysis of the International Youth Development Study.

Identifying specific aspects of peer social norms that influence adolescent substance use may assist international prevention efforts. This study examines two aggregated measures of social norms in the school setting and their predictive association with substance (alcohol, tobacco and marijuana) use 2 years later in a large cross-national population-based cohort of adolescents. The primary hypothesis is that in Grade 7 both "injunctive" school norms (where students associate substance use with "coolness") and "descriptive" norms (where student substance use is common) will predict Grade 9 substance use. Data come from the International Youth Development Study, including 2,248 students (51.2% female) in the US and Australia attending 121 schools in Grade 7. Independent variables included injunctive norms (aggregating measures of school-wide coolness ratings of each substance use) and descriptive norms (aggregating the prevalence of school substance use) in Grade 7. Dependent variables included binge drinking and current use of alcohol, tobacco and marijuana in Grade 9. Associations between each type of school-wide social norm and substance use behaviors in Grade 9 were tested using multilevel logistic regression, adjusting for covariates. In unadjusted models, both injunctive and descriptive norms each significantly predicted subsequent substance use. In fully adjusted models, injunctive norms were no longer significantly associated with Grade 9 use, but descriptive norms remained significantly associated with tobacco and marijuana use in the expected direction. The findings identify descriptive social norms in the school context as a particularly important area to address in adolescent substance use prevention efforts

The interaction of Trypanosoma congolense with endothelial cells

Factors which affect adhesion of cultured Trypanosoma congolense bloodstream forms to mammalian feeder cells have been examined. Using an in vitro binding assay, the initial events following interaction of trypanosomes with bovine aorta endothelial (BAE) cells were monitored by both light- and electron microscopy. Metabolic inhibitors and other biochemicals were incubated with either cells or parasites, to test whether any inhibited the process. Our findings suggest that adhesion of the parasites is an active process requiring metabolic energy from the trypanosomes, but not from endothelial cells. We also provide data suggesting that T. congolense bloodstream forms possess a lectin-like domain, localized at distinct sites on their flagellar surface, which interacts with specific carbohydrate receptors, most likely sialic acid residues, on the endothelial cell plasma membrane. We also suggest that the cytoskeletal protein actin is probably involved in this interactio