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Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable AlCl<sub>3</sub> Immobilized on γ-Al<sub>2</sub>O<sub>3</sub>
<div><p></p><p>There is rapidly growing interest in the synthesis and use of substituted 1,2,3-triazoles. We report an easy and interesting procedure that demonstrates the effectiveness of surface-modified γ-Al<sub>2</sub>O<sub>3</sub>, which is reusable, efficient, catalytic, safe, and environmentally acceptable for the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via [3 + 2] cycloaddition of phenyl and benzyl azides with a series of aryl nitroolefins in good yields. No adverse effect on substituents such as nitro, cyano, hydroxy, ether linkage, and halogens was observed. The catalyst could easily be recycled and was reused for nine runs without losing its activity.</p></div