59 research outputs found

    Enzyme-based Electrochemical Biosensors

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    SPar: estimating stellar parameters from multi-band photometries with empirical stellar libraries

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    Modern large-scale photometric surveys have provided us with multi-band photometries of billions of stars. Determining the stellar atmospheric parameters, such as the effective temperature (\teff) and metallicities (\feh), absolute magnitudes (MGM_{G}), distances (dd) and reddening values (\ebr) is fundamental to study the stellar populations, structure, kinematics and chemistry of the Galaxy. This work constructed an empirical stellar library which maps the stellar parameters to multi-band photometries from a dataset with Gaia parallaxes, LAMOST atmospheric parameters, and optical to near-infrared photometry from several photometric surveys. Based on the stellar library, we developed a new algorithm, SPar (\textbf{S}tellar \textbf{P}arameters from multib\textbf{a}nd photomet\textbf{r}y), which fits the multi-band stellar photometries to derive the stellar parameters (\teff, \feh, MGM_G, dd and \ebr) of the individual stars. The algorithm is applied to the multi-band photometric measurements of a sample of stars selected from the SMSS survey, which have stellar parameters derived from the spectroscopic surveys. The stellar parameters derived from multi-band photometries by our algorithm are in good agreement with those from the spectroscopic surveys. The typical differences between our results and the literature values are 170\,K for \teff, 0.23\,dex for \feh, 0.13\,mag for MGM_G and 0.05\,mag for \ebr. The algorithm proved to be robust and effective and will be applied to the data of future large-scale photometric surveys such as the Mephisto and CSST surveys.Comment: 16 pages, 10 figures, Accepted by The Astronomical Journal on 7/8/202

    Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

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    Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells

    Redesign of service modes for remanufactured products and its financial benefits

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    Remanufacturing has gained an increasing amount of attention due to its contribution to energy saving and pollution reduction. However, remanufactured products have low customer acceptance because people are concerned about quality and after-sales service. Therefore, existing innovative service modes for regular products are used as the basis in this study to develop two different types of service modes (i.e., extended warranty and free replacement service modes) for remanufactured products. Mathematical models are further developed to evaluate the financial benefits that take into consideration linear and nonlinear customer demands. With a sample of 387 customers of remanufactured heavy truck engines, if and how these two new service modes can provide financial gains to a typical leading remanufacturer will be examined in this paper. The empirical analysis results show that customers prefer to buy remanufactured products at a higher price if the new service modes are implemented. However, the profit of remanufacturers will be affected by the increased cost and defect products. Hence, it is essential to observe whether there is a balance between increased benefits and costs when determining the length of the extended warranty and the free replacement service. The empirical results indicate that remanufacturers can gain more profit with the free replacement service mode as opposed to the extended warranty service mode. This study provides practical implications by developing two innovative service modes that can be implemented by remanufacturers. The study also theoretically contributes to the field of study with the development of mathematical models to evaluate the financial benefits that take into consideration the different types of customer demands as well as other innovative service modes among remanufacturers and manufacturers

    Quantitative analysis of the impact of COVID-19 on ship visiting behaviors to ports- A framework and a case study

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    Funding Information: This study is supported by the National Natural Science Foundation of China, China (Grant No. 52171351 ). Publisher Copyright: © 2022 The Author(s)Corona Virus Disease 2019 (COVID-19) outbreak leads to a significant downturn in the global economy and supply chain. In the maritime sector, trade volume slumped by 3.8% in 2020 compared with 2019. To explore the impacts of COVID-19 on ship visiting behaviors, a framework is proposed to analyze the impact of COVID-19 on port traffic using Automatic Identification System (AIS) data. Firstly, a ship travel behavior-based model is proposed to identify the vessel anchoring and berthing. Then, the diversity in vessel anchoring and berthing time are analyzed, reflecting the impact of COVID-19. The port congestion caused by COVID-19 is quantified by accounting for the number of visiting ships and their residence time. Finally, a case study is carried out on vessels in the Beibu Gulf, China, operating from 2019 to 2020. The results show that the average anchoring time and berthing time increase by 62% and 11% for cargo ships and by 112% and 63% for oil tankers after the outbreak of COVID-19 compared with that beforeCOVID-19. And the density of ships increases in the port area in 2020. Accordingly, the relevant improvements and countermeasures are proposed to reduce the adverse impact of the epidemic on the port navigation system. The paper has the potential to provide a reference for port management and improving port navigation efficiency in the post-pandemic era.Peer reviewe

    Research on Construction and SWRL Reasoning of Ontology of Maize Diseases

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    International audienceIn this paper, according to the characteristics of maize disease knowledge, OWL DL language was used to build maize diseases ontology, and the reasoning rule of maize diseases was defined by using the expressive ability of SWRL rule language.The author introduced several realizable reasoning functions,and achieved the diagnostic reasoning of maize disease knowledge by Jess inference engine.The results indicated that constructing the maize diseases ontology,and introducing SWRL rule into maize disease ontology provided an effective way for the construction of high-intelligent, shareable and reused maize disease knowledge database and diagnostic rule database
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