Relationship Between Duration of Type 2 Diabetes and Effectiveness of DPP-4 Inhibitor Versus Sulfonylurea as Add-on Therapy: A Post Hoc Analysis

<p><strong>Article full text</strong></p> <p><br> The full text of this article can be found <a href="https://link.springer.com/article/10.1007/s13300-017-0276-1"><b>here</b>.</a><br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact <u>[email protected]</u>.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides<u></u></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p

Sociodemographic and medical data of smokers and non-smokers.

<p>Sociodemographic and medical data of smokers and non-smokers.</p

Multivariate logistic regression model of characteristics associated with readiness to stop smoking among current smokers (N = 221).

<p>Multivariate logistic regression model of characteristics associated with readiness to stop smoking among current smokers (N = 221).</p

Smoking characteristics of participants who smoke (N = 221).

<p>Smoking characteristics of participants who smoke (N = 221).</p

Fold changes of mRNA expression of DNA BER enzymes.

<p>T2DM patients with HbA1c>7.5% (n = 23) in relation to matched T2DM patients with HbA1c<7.5% (n = 23). For each pair, results were normalized to the HbA1c<7.5% expression. Matching was according to age, medication and smoking history. Significance was assumed at p<0.05 and tested with one-sample t-test against “1” or Wilcoxon test against “1” if normal distribution was not assumed. (a) Fold-changes presented as bar plots showing mean and standard deviation. (b) Distribution of fold changes. Each point represents a matching pair (n = 23).</p

Primer sequences for gene expression analyses.

<p>Primer sequences for gene expression analyses.</p

Differences between HbA1c groups in DNA damage, BER capacity, oxidative stress parameters and antioxidant enzyme activities.

<p>Differences between HbA1c groups in DNA damage, BER capacity, oxidative stress parameters and antioxidant enzyme activities.</p