3,154 research outputs found
Upper gastrointestinal Crohn's disease
Symptomatic gastroduodenal manifestations of Crohn's disease are rare, with less than 4% of patients being clinically symptomatic. Gastroduodenal involvement may, however, be found endoscopically in 20% and in up to 40% of cases histologically, most frequently as Helicobacter pylori-negative focal gastritis, usually in patients with concomitant distal ileal disease. In practice, the activity of concomitant distal Crohn's disease usually determines the indication for therapy, except in the presence of obstructive gastroduodenal symptoms. With the few data available, it seems correct to say that localized gastroduodenal disease should be treated with standard medical therapy used for more distal disease, with the exception of the galenic formulation of sulfasalazine and mesalazine with pH-dependent release. The presence of symptoms of obstruction needs aggressive therapy. If medical therapy with steroids and immunomodulatory drugs does not alleviate the symptoms, balloon dilation and surgery are the options to consider. [Ed.]]]>
oai:serval.unil.ch:BIB_5E8B8CEC2A7F
2022-05-07T01:18:50Z
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Agniṣṭoma and the nature of sacrifice
Bronkhorst, Johannes
info:eu-repo/semantics/bookPart
incollection
2016
On Meaning and Mantras: Essays in Honor of Frits Staal, pp. 79-99
Thompson, George (ed.)
Payne, Richard K. (ed.)
info:eu-repo/semantics/altIdentifier/isbn/978-1-886439-64-1
eng
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oai:serval.unil.ch:BIB_5E8C17A3E220
2022-05-07T01:18:50Z
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https://serval.unil.ch/notice/serval:BIB_5E8C17A3E220
Selective regulation of acid-sensing ion channel 1 by serine proteases.
info:doi:10.1074/jbc.M407381200
info:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M407381200
info:eu-repo/semantics/altIdentifier/pmid/15247234
Poirot, O.
Vukicevic, M.
Boesch, A.
Kellenberger, S.
info:eu-repo/semantics/article
article
2004
Journal of Biological Chemistry, vol. 279, no. 37, pp. 38448-38457
info:eu-repo/semantics/altIdentifier/pissn/0021-9258[print], 0021-9258[linking]
<![CDATA[Acid-sensing ion channels (ASICs) are neuronal Na(+) channels that belong to the epithelial Na(+) channel/degenerin family. ASICs are transiently activated by a rapid drop in extracellular pH. Conditions of low extracellular pH, such as ischemia and inflammation in which ASICs are thought to be active, are accompanied by increased protease activity. We show here that serine proteases modulate the function of ASIC1a and ASIC1b but not of ASIC2a and ASIC3. We show that protease exposure shifts the pH dependence of ASIC1a activation and steady-state inactivation to more acidic pH. As a consequence, protease exposure leads to a decrease in current response if ASIC1a is activated by a pH drop from pH 7.4. If, however, acidification occurs from a basal pH of approximately 7, protease-exposed ASIC1a shows higher activity than untreated ASIC1a. We provide evidence that this bi-directional regulation of ASIC1a function also occurs in neurons. Thus, we have identified a mechanism that modulates ASIC function and may allow ASIC1a to adapt its gating to situations of persistent extracellular acidification
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using purified components in the presence of ATP-γS, we have captured in vitro an intermediate in pre-RC assembly that contains a complex between the ORC-Cdc6 and Cdt1-MCM2-7 heteroheptamers called the OCCM. Cryo-EM studies of this 14-subunit complex reveal that the two separate heptameric complexes are engaged extensively, with the ORC-Cdc6 N-terminal AAA+ domains latching onto the C-terminal AAA+ motor domains of the MCM2-7 hexamer. The conformation of ORC-Cdc6 undergoes a concerted change into a right-handed spiral with helical symmetry that is identical to that of the DNA double helix. The resulting ORC-Cdc6 helicase loader shows a notable structural similarity to the replication factor C clamp loader, suggesting a conserved mechanism of action
Scattering of Giant Magnons in CP^3
We study classical scattering phase of CP^2 dyonic giant magnons in R_t x
CP^3. We construct two-soliton solutions explicitly by the dressing method.
Using these solutions, we compute the classical time delays for the scattering
of giant magnons, and compare them to boundstate S-matrix elements derived from
the conjectured AdS_4/CFT_3 S-matrix by Ahn and Nepomechie in the strong
coupling limit. Our result is consistent with the conjectured S-matrix. The
dyonic solutions play an essential role in revealing the polarization
dependence of scattering phase.Comment: 29 pages; v2: minor corrections; v3: minor corrections, references
added ; v4: minor corrections ; v5: minor corrections based on the published
versio
Economic Evaluation of a School-based Combined Program with a Targeted Pit and Fissure Sealant and Fluoride Mouth Rinse in Japan
Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV
The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8 TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum
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