Lichen ranges, animal densities and production in Finnish reindeer management

In the 1970s, mean lichen biomass ranged by the earmark districts (comprising of 2-9 adjacent herding associations) between 54 kg and 380 kg DM per ha correlating negatively with animal density per lichen ranges (range 1.5 - 14.3 ind. per km2). Biomasses were far below economic carrying capacity of lichen ranges (900 kg DM per ha). The condition of lichen ranges was poorest in the southern half of the area where alternative food to reindeer lichens (Deschampsia flexuosa, arboreal lichens and supplementary feeding) was available. In 1980-86, recruitment (calves per 100 females) was 33% higher than in the 1970's, on an average (65 vs. 49), despite a 90% increase in animal numbers between 1970 and 1986; recruitment has not been dependent on the condition of lichen ranges. The increase in production has been some higher than expected on the basis of animal numbers. The reasons for the increasing trends in animal numbers, recruitment and production remains some unclear, but they may include favorable winter conditions, supplementary feeding, medical treatment against parasites and proper harvesting policy

The effects of stand characteristics on reindeer lichens and range use by semi-domesticated reindeer

The study was carried out in Kuusamo (66°15'N, 29°05'E) and Inari (68°30'N, 28°15'E), northern Finland, where 24 and 22 Scots pine stands were studied respectively. Clear-cutting (logging residue) caused a decline in lichen biomass for some few years, but otherwise the age of the stand had no effect upon lichen biomass. Instead, a positive correlation was found between litter/logging residue and the mean height of lichens; in Kuusamo, logging residue decreased significantly with the age of the stand. Grazing pressure in terms of fecal group density increased with the age of the stand. The preference of old forests came visible also as a lower mean height of lichens, which eliminates the possibility that the preference of old forests is associated only to the use of arboreal lichens. In Inari, grazing pressure sharply increased after the stand had reached the age of 100 years despite scarce litter/logging residue and fair lichen ranges in younger forests; there prevailed a negative correlation between stand density and grazing pressure. It has been suggested that there might be three main reasons for reindeers preferring old forests: 1) hardening of the snow (because of winds) on clear-cut areas, 2) logging residue preventing digging for the food beneath the snow, and 3) poor visibility in young pine stands (Inari) which might increase predation risk

Scaling Laws of Stress and Strain in Brittle Fracture

A numerical realization of an elastic beam lattice is used to obtain scaling exponents relevant to the extent of damage within the controlled, catastrophic and total regimes of mode-I brittle fracture. The relative fraction of damage at the onset of catastrophic rupture approaches a fixed value in the continuum limit. This enables disorder in a real material to be quantified through its relationship with random samples generated on the computer.Comment: 4 pages and 6 figure

Brain glycogen—new perspectives on its metabolic function and regulation at the subcellular level

Glycogen is a complex glucose polymer found in a variety of tissues, including brain, where it is localized primarily in astrocytes. The small quantity found in brain compared to e.g., liver has led to the understanding that brain glycogen is merely used during hypoglycemia or ischemia. In this review evidence is brought forward highlighting what has been an emerging understanding in brain energy metabolism: that glycogen is more than just a convenient way to store energy for use in emergencies—it is a highly dynamic molecule with versatile implications in brain function, i.e., synaptic activity and memory formation. In line with the great spatiotemporal complexity of the brain and thereof derived focus on the basis for ensuring the availability of the right amount of energy at the right time and place, we here encourage a closer look into the molecular and subcellular mechanisms underlying glycogen metabolism. Based on (1) the compartmentation of the interconnected second messenger pathways controlling glycogen metabolism (calcium and cAMP), (2) alterations in the subcellular location of glycogen-associated enzymes and proteins induced by the metabolic status and (3) a sequential component in the intermolecular mechanisms of glycogen metabolism, we suggest that glycogen metabolism in astrocytes is compartmentalized at the subcellular level. As a consequence, the meaning and importance of conventional terms used to describe glycogen metabolism (e.g., turnover) is challenged. Overall, this review represents an overview of contemporary knowledge about brain glycogen and its metabolism and function. However, it also has a sharp focus on what we do not know, which is perhaps even more important for the future quest of uncovering the roles of glycogen in brain physiology and pathology

CT versus FDG-PET/CT response evaluation in patients with metastatic colorectal cancer treated with irinotecan and cetuximab

We compared morphologic computed tomography (CT)-based to metabolic fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT-based response evaluation in patients with metastatic colorectal cancer and correlated the findings with survival and KRAS status. From 2006 to 2009, patients were included in a phase II trial and treated with cetuximab and irinotecan every second week. They underwent FDG-PET/CT examination at baseline and after every fourth treatment cycle. Response evaluation was performed prospectively according to Response Evaluation Criteria in Solid Tumors (RECIST 1.0) and retrospectively according to Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST). Best overall responses were registered. Sixty-one patients were eligible for response evaluation. Partial response (PR) rate was 18%, stable disease (SD) rate 64%, and progressive disease (PD) rate 18%. Partial metabolic response (PMR) rate was 56%, stable metabolic disease rate 33%, and progressive metabolic disease (PMD) rate 11%. Response agreement was poor, κ-coefficient 0.19. Hazard ratio for overall survival for responders (PR/PMR) versus nonresponders (PD/PMD) was higher for CT- than for FDG-PET/CT evaluation. Within patients with KRAS mutations, none had PR but 44% had PMR. In conclusion, morphologic and metabolic response agreement was poor primarily because a large part of the patients shifted from SD with CT evaluation to PMR when evaluated with FDG-PET/CT. Furthermore, a larger fraction of the patients with KRAS mutations had a metabolic treatment response

Acuity, crowding, reading and fixation stability

AbstractPeople with age-related macular disease frequently experience reading difficulty that could be attributed to poor acuity, elevated crowding or unstable fixation associated with peripheral visual field dependence. We examine how the size, location, spacing and instability of retinal images affect the visibility of letters and words at different eccentricities. Fixation instability was simulated in normally sighted observers by randomly jittering single or crowded letters or words along a circular arc of fixed eccentricity. Visual performance was assessed at different levels of instability with forced choice measurements of acuity, crowding and reading speed in a rapid serial visual presentation paradigm. In the periphery: (1) acuity declined; (2) crowding increased for acuity- and eccentricity-corrected targets; and (3), the rate of reading fell with acuity-, crowding- and eccentricity-corrected targets. Acuity and crowding were unaffected by even high levels of image instability. However, reading speed decreased with image instability, even though the visibility of the component letters was unaffected. The results show that reading performance cannot be standardised across the visual field by correcting the size, spacing and eccentricity of letters or words. The results suggest that unstable fixation may contribute to reading difficulties in people with low vision and therefore that rehabilitation may benefit from fixation training