119 research outputs found
Minimal residual disease in breast cancer: an overview of circulating and disseminated tumour cells
ChemInform Abstract: Heterocyclic Quinones. Part 16. Pharmacomodulation in the Series of 11H-Indolo(3,2-c)quinolinediones: Synthesis, Cytotoxicity, and Antitumor Activity of 3-Substituted 11H-Pyrido(3â˛,4â˛:4,5)pyrrolo(3,2-c)quinoline-1,4-diones.
Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives
Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers. Its clinical management remains unclear, and few preclinical data are available on its underlying pathophysiology. The therapeutic strategy is difficult to establish because few prospective and randomized trials are available. In this review, we report on the clinical presentation and pathophysiology of radiation cystitis. Then we discuss potential therapeutic approaches, with a focus on the immunopathological processes underlying the onset of radiation cystitis, including the fibrotic process. Potential therapeutic avenues for therapeutic modulation will be highlighted, with a focus on the interaction between mesenchymal stromal cells and macrophages for the prevention and treatment of radiation cystitis
Structure-mutagenicity relationships in a series of indolo[3,2-c]quinoline-1,4-diones that have shown cytotoxic properties on leukemia cells
ChemInform Abstract: A Convenient Synthesis of 1H-Pyrrolo(3,2-c)quinoline-6,9-diones and 11H-Indolo(3,2-c)quinoline-1,4-diones Derivatives.
ChemInform Abstract: Heterocyclic Quinones. Part 14. Pharmacomodulation in a Series of 11H-Indolo(3,2-c)quinolinediones: Synthesis and Cytotoxicity of 8-Substituted 11H-Indolo(3,2-c)quinoline-7,10-diones.
La dengue dans l'archipel de la Guadeloupe
ABYMES-CHRUPPA-BU (971202102) / SudocNANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF
A three step one-pot regioselective synthesis of highly substituted pyrazolo[1,5-a]pyrimidines assisted by KHSO4 in aqueous media under ultrasound irradiation
A simple and efficient synthesis of substituted pyrazolo[1,5-a]pyrimidine derivatives has been developed by the use of ultrasound. 5-Methyl-4-phenyl-1H-pyrazol-3-amine required for the synthesis of pyrazolo[1,5-a]pyrimidine derivatives has been easily obtained by the reaction of 3-(dimethylamino)-2-phenylacrylonitrile (formed from readily available 2-phenylacetonitrile) with hydrazine hydrate in refluxing ethanol. The 5-aminopyrazole was then reacted with various formylated active proton compounds in presence of KHSO4 in aqueous medium under ultrasound irradiation to give the desired products. The chemical structures of the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and Mass spectral data. X-ray crystallographic study of a selected compound 6-(4-chlorophenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine (7c) was performed to ascertain the regioselectivity of the reaction. Crystal data for compound 7c: Triclinic, space group P-1 (no. 2), a = 8.0198(3) Ă
, b = 14.0341(6) Ă
, c = 14.2099(6) Ă
, ι = 87.672(2)°, β = 83.902(2)°, γ = 89.120(2)°, V = 1588.87(11) Ă
3, Z = 4, T = 293(2) K, Îź(MoKÎą) = 0.248 mm-1, Dcalc = 1.400 g/cm3, 12918 reflections measured (4.012° ⤠2Π⤠49°), 5152 unique (Rint = 0.0411, Rsigma = 0.0429) which were used in all calculations. The final R1 was 0.0486 (I > 2Ď(I)) and wR2 was 0.1320 (all data)
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