The neurological wake-up test in severe pediatric traumatic brain injury: a long term, single-center experience

ObjectivesTo describe the use and outcomes of the neurological wake-up test (NWT) in pediatric severe traumatic brain injury (pTBI).DesignRetrospective single-center observational cohort study.SettingMedical-surgical tertiary pediatric intensive care unit (PICU) in a university medical center and Level 1 Trauma Center.PatientsChildren younger than 18 years with severe TBI [i.e., Glasgow Coma Scale (GCS) of ≤8] admitted between January 2010 and December 2020. Subjects with non-traumatic brain injury were excluded.Measurements and main resultsOf 168 TBI patients admitted, 36 (21%) met the inclusion criteria. Median age was 8.5 years [2 months to 16 years], 5 patients were younger than 6 months. Median initial Glasgow Coma Scale (GCS) and Glasgow Motor Scale (GMS) was 6 [3–8] and 3 [1–5]. NWTs were initiated in 14 (39%) patients, with 7 (50%) labelled as successful. Fall from a height was the underlying injury mechanism in those seven. NWT-failure occurred in patients admitted after traffic accidents. Sedation use in both NWT-subgroups (successful vs. failure) was comparable. Cause of NWT-failure was non-arousal (71%) or severe agitation (29%). Subjects with NWT failure subsequently had radiological examination (29%), repeat NWT (43%), continuous interruption of sedation (14%) or intracranial pressure (ICP) monitoring (14%). The primary reason for not doing NWTs was intracranial hypertension in 59%. Compared to the NWT-group, the non-NWT group had a higher PRISM III score (18.9 vs. 10.6), lower GCS/GMS at discharge, more associated trauma, and circulatory support. Nine patients (25%) died during their PICU admission, none of them had an NWT.ConclusionWe observed limited use of NWTs in pediatric severe TBI. Patients who failed the NWT were indistinguishable from those without NWT. Both groups were more severely affected compared to the NWT successes. Therefore, our results may indicate that only a select group of severe pTBI patients qualify for the NWT

Ursinus College Alumni Journal, July 1959

President\u27s page • D. L. Helfferich received LL.D. • 172 graduate at 90th commencement • Dr. Paul Miller commencement speaker • Dr. Sieb Pancoast resigns as Ursinus Dean of Men • Admissions office expects 250 freshmen in \u2763 class • Mr. Wilcox received doctorate from Penn • Rev. Jerry William Trexler speaker at Baccalaureate • Dean Camilla B. Stahr retires - Dean of Women since 1938 • Ralph Strassburger leaves half of his estate to charity • Ruth H. Rothenberger, \u2736 - new Dean of Women • Ursinus College has outstanding Loyalty Fund record • Rev. Richard Schellhase \u2745 - new Alumni Exec. Sec. • Festive Alumni Day brings large crowd • Paul I. Guest reelected alumni president • New York regional alumni elect new officers • The Collegeville Summer Assembly • May Day • Overseas job opportunities • Ursinus Women\u27s Club activities • Class \u2759 elects permanent officers • Old Timer\u27s Day Saturday November 7 • College teachers recognized • Baseball 1959 • 1959 track season • Ursinus girls complete undefeated spring • Lacrosse • National honors for Crosley • Softball • Tennis • News about ourselves • Weddings • Birthshttps://digitalcommons.ursinus.edu/alumnijournal/1064/thumbnail.jp

Ursinus College Alumni Journal, March 1959

President\u27s page • Radioactivity detection in civil defense course • From the Dean\u27s office • University of the Air • From the Office of Admissions • The library • Industrial gift trend is up • G. E. corporate alumnus program • duPont renews $4000 grant •$2000 Esso education foundation grant • Regional groups plan meetings • Philadelphia alumni install 1959 officers • South Jersey alumni plan supper party • New York alumni plan spring dinner • Washington D.C. alumni plan annual dinner • York alumni elect new officers for 1959 • Ursinus Woman\u27s Club plans spring card party • Alumni Day, Saturday, June 6 • Donald Schultz, \u2750 wilderness medic • 1901 schoolgirl driver Rhea Duryea Johnson \u2708 • International educator, scholar and editor, Jacob Foose \u2732 • January 1959 mid year report of the Loyalty Fund Campaign • Mid campaign report • Alumni elections: Watch for your ballot in April • Requests • Football 1958 • Wrestling 1959 • Alumnae hockey 1958 • Alumnae finish undefeated for second year • Proposed amended constitution • News about ourselves • Weddings • Births • Necrology • Chase Manhattan Bank employee gift matching • Saturday, June 6, 1959: Alumni festivalhttps://digitalcommons.ursinus.edu/alumnijournal/1067/thumbnail.jp

Ursinus College Alumni Journal, November 1966

\u2770 is here • And \u2770 says: Centennial Fund, roll on! • From the President • For Alumni Association leaders, Homecoming Day was some work and plenty of play • An Ursinus specialty: Shaping the future physician • New placement service for alumni • Huck Finn\u27s dilemma is ours • The paradox of urbia • The theatre of the absurd emerges in Latin America • An age of reforming in liberal education: Trends at Ursinus compare with reforms proposed at Columbia University • Sporting scene: Women undefeated in hockey; Soccer; Cross country; Football • Campus clippings: Founders\u27 Day; Sigma Xi Club; Research at Ursinus; Student teachers; The Agency; Mr. Rue remembers; On army duty; Evening school grows; Neighbors come to dinner; Lindback scholar; Parents Day; Job opportunity; \u2767 Ruby underway • Class notebook • Weddings • Births • In memoriamhttps://digitalcommons.ursinus.edu/alumnijournal/1085/thumbnail.jp

The Ursinus Weekly, April 25, 1949

Cancer drive opens on Ursinus campus to fill urgent need • Cub and Key receives seven juniors • Club 49 announces re-opening April 29 with Louie manager • Annual tapping honors campus leaders at butterfly ball • British labor man to address forum on labor movement • Men\u27s government okays concessions in student business • Thespians to depict individualists\u27 life in May production • Steele to consider scripture reliability • Warren takes lead in May Day frolic • ICG delegates to visit capital, observe legislature in action • Relax, reflect in record room • What would you demand of your ideal woman? • Darkie ensemble whams fellow students in deluge of cracks and various routines • Adair blanks bruin nine; Explorers explode at bat • Spring inaugurates interdorm softball • Baseballers break losing jinx; Russ Binder sets new record • Quay pitches brilliantly in relief role; Leander leads batsmen with four hits • Sprint star runs \u27100\u27 in 9.8 seconds as bruins bow to Haverford 79-47 • Softballers win 11-0 in exhibition game with Garnet coeds • Coach Dennis hopes to rejuvenate golf for \u2749 campaign • Muddy courts delay opening of season with Elizabethtown • Belated tennis season begins; Meet Bryn Mawr on Wednesday • Juniors crown Neill queen of evening at \u2749 butterfly ballhttps://digitalcommons.ursinus.edu/weekly/1615/thumbnail.jp

Neurofibromatosis type 1 associated low grade gliomas:A comparison with sporadic low grade gliomas

AbstractNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder, associated with a variable clinical phenotype including café-au-lait spots, intertriginous freckling, Lisch nodules, neurofibromas, optic pathway gliomas and distinctive bony lesions. NF1 is caused by a mutation in the NF1 gene, which codes for neurofibromin, a large protein involved in the MAPK- and the mTOR-pathway through RAS-RAF signalling.NF1 is a known tumour predisposition syndrome, associated with different tumours of the nervous system including low grade gliomas (LGGs) in the paediatric population. The focus of this review is on grade I pilocytic astrocytomas (PAs), the most commonly observed histologic subtype of low grade gliomas in NF1. Clinically, these PAs have a better prognosis and show different localisation patterns than their sporadic counterparts, which are most commonly associated with a KIAA1549:BRAF fusion.In this review, possible mechanisms of tumourigenesis in LGGs with and without NF1 will be discussed, including the contribution of different signalling pathways and tumour microenvironment. Furthermore we will discuss how increased understanding of tumourigenesis may lead to new potential targets for treatment

Ursinus College Alumni Journal, November 1958

President\u27s page • President\u27s inaugural address • Dr. D. L. Helfferich inaugurated President of Ursinus College • Ursinus College opens with 839 • The Evening School • New preceptress at 944 • Library • The Messiah • The faculty cornered • The cornered faculty turns • Tracking the Alder Flycatcher • Old Timers\u27 Day almost rained out • Face lifting on campus • Ursinus Woman\u27s Club plans holiday luncheon • Ursinus Forum, 1958-59 • A challenge for alumni giving • Fall play Joan of Lorraine • Annual alumni Schoolmen\u27s Week luncheon • Five years of alumni sponsorship completed: 1958 Loyalty Fund report • Workshop in economic education • Paul S. Craigie, class Chairman of the year • Honor roll by classes • Contributors for the 1958 Loyalty Fund campaign • Varsity football • Varsity and J.V. basketball schedule 1958-59 • Alumnae continue winning ways • Varsity wrestling schedule 1959 • Two new assistant football coaches • Varsity has strong potential • Ursinus appoints a new wrestling coach • News about ourselves • Weddings • Births • Necrology • Two Spanish majors receive honorshttps://digitalcommons.ursinus.edu/alumnijournal/1063/thumbnail.jp