Widely applicable coinage metal window electrodes on flexible polyester substrates applied to organic photovoltaics

The fabrication, exceptional properties, and application of 8 nm thick Cu, Ag, Au, and Cu/Ag bilayer electrodes on flexible polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) substrates is reported. These electrodes are fabricated using a solvent free process in which the plastic surface is chemically modified with a molecular monolayer of thiol and amine terminated alkylsilanes prior to metal deposition. The resulting electrodes have a sheet resistance of ≤14 Ω sq–1, are exceptionally robust and can be rapidly thermally annealed at 200 °C to reduce their sheet resistance to ≤9 Ω sq–1. Notably, annealing Au electrodes briefly at 200 °C causes the surface to revert almost entirely to the {111} face, rendering it ideal as a model electrode for fundamental science and practical application alike. The power conversion efficiency of 1 cm2 organic photovoltaics (OPVs) employing 8 nm Ag and Au films as the hole-extracting window electrode exhibit performance comparable to those on indium–tin oxide, with the advantage that they are resistant to repeated bending through a small radius of curvature and are chemically well-defined. OPVs employing Cu and bilayer Cu:Ag electrodes exhibit inferior performance due to a lower open-circuit voltage and fill factor. Measurements of the interfacial energetics made using the Kelvin probe technique provide insight into the physical reason for this difference. The results show how coinage metal electrodes offer a viable alternative to ITO on flexible substrates for OPVs and highlight the challenges associated with the use of Cu as an electrode material in this contex

Establishing the validity of domestication genes using DNA from ancient chickens

Peer reviewedPostprin

Find the one you like! Profiling Swiss parks with user generated content

The establishment of national parks originated from the desire to preserve scenic landscape areas of national or regional importance. With more recent diversification of protected area types and goals, obtaining knowledge on how parks are recreationally used has become more challenging for (local) policy makers and park managements, as there is a general lack of systematic and publicly available visitor monitoring data. We analyze recreational park use for 20 Swiss parks of national importance and develop park profiles, using user-generated content from Flickr. The 20 Swiss parks are described by 111,437 unique images taken by 6,468 unique users between 2007 and 2020. We fill an existing research gap by defining park use across three dimensions space, time and users, and combining these in our analyses. The park profiles provide information on diversity of recreational use and serve as a starting point for analyzing how the three dimensions contribute to this diversity. Our results show diverging park uses for the three dimensions indicating that park location matters, especially in terms of peri-urbanity and geographic region. Our method can be translated into European scale analyses, provided that different languages are considered. Park profiles are easy to communicate and easy to interpret tools for (local) policy-makers and park managers to segment the tourism market and develop new park marketing strategies to e.g. streamline visitation flows and reduce the negative impacts of outdoor recreation. In broader terms, our study serves as input for future recreation policy to protect, restore and promote sustainable use of protected areas Management implications • We offer insights into recreational park use in terms of users, space and time, particularly valuable for parks where monitoring visitation is vital (i.e. protected areas). • Park profiles provide easy to communicate and interpret extensible tools for (local) policy-makers and park managers. • Park profiles can be used for among others the development of new park marketing strategies catering preferences for differentiated user groups. • Since different recreational user groups differ in their recreational behavior and in turn their environmental impact, park profiles can help in streamlining visitors as a potentially effective management measure for increased park sustainability (e.g. biodiversity conservation)

The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

In this review, we examine senescent cells and the overlap between the direct biological impact of senescence and the indirect impact senescence has via its effects on other cell types, particularly the macrophage. The canonical roles of macrophages in cell clearance and in other physiological functions are discussed with reference to their functions in diseases of the kidney and other organs. We also explore the translational potential of different approaches based around the macrophage in future interventions to target senescent cells, with the goal of preventing or reversing pathologies driven or contributed to in part by senescent cell load in vivo

Brexit’s shades of green – (missing) the opportunity to transform farming in England?

The UK Government’s ‘green Brexit’ includes fundamental reform of agriculture. We use resilience thinking to examine the complex relationship between farming policy and environmental sustainability. Farming is a social ecological system that will be disturbed by leaving the EU’s Common Agricultural Policy. Reforms could reinforce persistence of the status quo or shape transformation to ‘better’ sustainability. We argue Brexit is a once-in-a-generation opportunity for the hegemony of sustainable intensification to be challenged by enhanced agroecological farming practices. The interdependency of social and ecological factors is a critical threshold for transformative change, which we explore through three key sites of struggle: farmers’ cultural identity, connection to land, and security. We suggest transformative law and governance measures built upon Wild Law jurisprudence and resilience principles of diversity, scale, flexibility, relationality, education and participatory decision-making. We conclude that the Government’s approach falls short of the transformation needed for a resilient, sustainable farming system

Tumor burden and liver function in HCC patient selection for selective internal radiation therapy: SARAH post-hoc study

Aim: To determine whether a liver tumor burden ≤25% and well-preserved liver function (albumin-bilirubin grade 1) are appropriate criteria for identifying patients with unresectable hepatocellular carcinoma who may benefit from selective internal radiation therapy (SIRT) using 90yttrium resin microspheres versus sorafenib. Patients & methods: Post-hoc analysis of patients in the intention-to-treat population of the SARAH trial (SIRT vs sorafenib) with ≤25% tumor burden and albumin-bilirubin grade 1. Primary end point: overall survival. Results: Median overall survival was 21.9 months (95% CI: 15.2–32.5, n = 37) with SIRT and 17.0 months (11.6–20.8, n = 48) with sorafenib (hazard ratios: 0.73; 95% CI: 0.44–1.21; p = 0.22). Conclusion: A combination of good liver function and low tumor burden may be relevant for selection of hepatocellular carcinoma patients for SIRT

Characteristics of surface-water flows in the ridge and slough landscape of Everglades National Park: implications for particulate transport

Over the last one hundred years, compartmentalization and water management activities have reduced water flow to the ridge and slough landscape of the Everglades. As a result, the once corrugated landscape has become topographically and vegetationally uniform. The focus of this study was to quantify variation in surface flow in the ridge and slough landscape and to relate flow conditions to particulate transport and deposition. Over the 2002–2003 and 2003–2004 wet seasons, surface velocities and particulate accumulation were measured in upper Shark River Slough in Everglades National Park. Landscape characteristics such as elevation, plant density and biomass also were examined to determine their impact on flow characteristics and material transport. The results of this study demonstrate that the release of water during the wet season not only increases water levels, but also increased flow speeds and particulate transport and availability. Further, flow speeds were positively and significantly correlated with water level thereby enhancing particulate transport in sloughs relative to ridges especially during peak flow periods. Our results also indicate that the distribution of biomass in the water column, including floating plants and periphyton, affects velocity magnitude and shape of vertical profiles, especially in the sloughs where Utricularia spp. and periphyton mats are more abundant. Plot clearing experiments suggest that the presence of surface periphyton and Utricularia exert greater control over flow characteristics than the identity (i.e., sawgrass or spike rush) or density of emergent macrophytes, two parameters frequently incorporated into models describing flow through vegetated canopies. Based on these results, we suggest that future modeling efforts must take the presence of floating biomass, such as Utricularia, and presence of periphyton into consideration when describing particulate transport

The effect of a full bladder on proportions of diagnostic ultrasound studies in children with suspected appendicitis

Objectives: We examined the effect of a full bladder on proportions of diagnostic ultrasound (US) studies in children with suspected appendicitis. We also examined the effect of a full bladder on proportions of fully visualized ovaries on US in children with suspected appendicitis. Methods: We conducted a retrospective health record review of children aged 2-17 years presenting to a tertiary pediatric emergency department (ED) with suspected appendicitis who had an ultrasound performed. We compared proportions of diagnostic US studies in children with full and sub-optimally filled bladders. We also compared proportions of ovarian visualization in females with full and sub-optimally filled bladders. Results: 678 children were included in our final analysis. The proportion of diagnostic US studies did not vary significantly between groups with a full (132/283, 47%, 95% confidence interval [CI] 38%-56%) or sub-optimally filled bladder (205/ 395, 52%, 95% CI 47%-57%) (p = 0.17). Rates of ovarian visualization were higher in females with a full bladder (196/ 205, 96%, 95% CI 93%-99%) compared to those with a suboptimally filled bladder (180/223, 81%, 95% CI 76%-86%) (p\u3c0.01). Conclusions: Administrators and clinical decision makers should consider removing routine bladder filling practice from current pediatric appendicitis protocols in males and in pre-pubertal females where ovarian pathology is not suspected. Selective bladder filling prior to US should be performed in females when ovarian pathology is suspected

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism. Despite this, drugs of this nature are currently limited to intramuscular administration routes due to intestinal degradation. The aim of this study was to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in improving host glucose, lipid and cholesterol metabolism in diet induced obese rodents. Diet-induced obese animals received either Lactobacillus paracasei NFBC 338 transformed to express a long-acting analogue of GLP-1 or the isogenic control microbe which solely harbored the pNZ44 plasmid. Short-term GLP-1 microbe intervention in rats reduced serum low-density lipoprotein cholesterol, triglycerides and triglyceride-rich lipoprotein cholesterol substantially. Conversely, extended GLP-1 microbe intervention improved glucose-dependent insulin secretion, glucose metabolism and cholesterol metabolism, compared to the high-fat control group. Interestingly, the microbe significantly attenuated the adiposity associated with the model and altered the serum lipidome, independently of GLP-1 secretion. These data indicate that recombinant incretin-secreting microbes may offer a novel and safe means of managing cholesterol metabolism and diet induced dyslipidaemia, as well as insulin sensitivity in metabolic dysfunction