Summary of reasons for screen-outs and exclusion from analysis by site.

<p>Percentages shown as a proportion of either total screened (above), or total enrolled (below)</p><p>* Volunteers may be excluded for multiple reasons therefore columns may sum to >100%</p><p>** Systolic blood pressure >140 mm Hg and/or diastolic blood pressure >90 mm Hg</p><p>*** Including headaches, cough, fever, suspected and confirmed malaria</p><p>**** Active STI, including candidiasis, one possible HSV-1 infection, lower abdominal pain in women, and Bartholin's abscess</p>‡<p>Including suspected and confirmed TB, pneumonia</p>†<p>Includes 125/184 (67.9%) medical exclusions not linked to infectious disease (e.g., trauma, diabetes, cancer)</p>§<p>Includes 4/17 (23.5%) medical exclusions not linked to infectious disease (3 peripheral neuropathy and 1 inebriation at time of visit)</p

Screened, enrolled and analyzed volunteers by site and gender.

<p>Screened, enrolled and analyzed volunteers by site and gender.</p

Map of study sites showing source populations, elevation (meters above sea level) and target enrolment.

<p>Map of study sites showing source populations, elevation (meters above sea level) and target enrolment.</p

Equivalent numbers of men and women aged 18-60 were screened for this study.

<p>Among the 2,990 volunteers screened, 2,387 were enrolled, and a further 263 were excluded from analysis leaving a final study cohort of 2,124 volunteers.</p