An analysis of the test results of forty master of science students on the NLN graduate nurse qualifying examination

Thesis (M.S.)--Boston Universit

European Survey Data on Attitudes to Equality and Human Rights Technical Paper. Research Series

This report maps the data available on attitudes to equality and human rights issues in Ireland collected in European surveys over the period 2000 to 2018. These surveys provide a rich source of evidence for researchers and policymakers in Ireland. We identify a total of 1,509 relevant questions from a search of over 125 attitude surveys. These questions are categorised according to the groups and topics addressed. We find that attitudes towards minority ethnic/nationality groups, gender/gender roles and social welfare recipients are the most widely covered. Questions on attitudes towards religious minorities, age groups/ageism, family status, disability and sexual orientation are much less common. Moreover, while the frequency of attitude questions relating to sexual orientation has increased over the period, questions on age and disability groups have declined. Within these equality groups the surveys cover a range of topics including social distance, social contact, tolerance and policy preferences

The Librarian and the Media Producer: Creating an Audio-Archive based on a Unique Collection

The Ken Saro-Wiwa Audio Archive is one example of how libraries can develop and extend the understanding of Special Collections, in this case a collection of death-row letters. Librarians need to give more thought to how to add value and understanding to Special Collections, and audio archives provide one possible route. There were extensive learning for both of the authors in the process; for the librarian, it was a journey of discovery into the world of sound; for the media producer, it was a journey through the sometimes complex area of Special Collections and Archives. Through collaborations, such as the one described below, libraries can maximise the visibility and use of their archives and special collections. Increasing visibility of such resources may help to acquire funding for new special collections, and may also encourage people to donate collections knowing that the library is open to exploring avenues to widely promote such collections

Using an Audio Archive to Promote Learning

Poster presentation at Maynooth University Teaching and Learning Showcase 2014 – 201

Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC expansion and behaviour. In this study, we determined whether alterations in the BMP pathway gene signature had any predictive value for therapeutic response by profiling 60 CML samples at diagnosis from the UK SPIRIT2 trial and correlating the data to treatment response using the 18-month follow-up data. There was significant deregulation of several genes involved in the BMP pathway with ACV1C, INHBA, SMAD7, SNAIL1 and SMURF2 showing differential expression in relation to response. Therapeutic targeting of CML cells using BMP receptor inhibitors, in combination with tyrosine kinase inhibitor (TKI), indicate a synergistic mode of action. Furthermore, dual treatment resulted in altered cell cycle gene transcription and irreversible cell cycle arrest, along with increased apoptosis compared to single agents. Targeting CML CD34+ cells with BMP receptor inhibitors resulted in fewer cell divisions, reduced numbers of CD34+ cells and colony formation when compared to normal donor CD34+ cells, both in the presence and absence of BMP4. In an induced pluripotent stem cell (iPSC) model generated from CD34+ hematopoietic cells, we demonstrate altered cell cycle profiles and dynamics of ALK expression in CML-iPSCs in the presence and absence of BMP4 stimulation, when compared to normal iPSC. Moreover, dual targeting with TKI and BMP inhibitor prevented the self-renewal of CML-iPSC and increased meso-endodermal differentiation. These findings indicate that transformed stem cells may be more reliant on BMP signalling than normal stem cells. These changes offer a therapeutic window in CML, with intervention using BMP inhibitors in combination with TKI having the potential to target LSC self-renewal and improve long-term outcome for patients

Selected Feeding Techniques to Improve Nutritional Status in Handicapped Children

Food, Nutrition and Institution Administratio

Saposins (sap) A and C activate the degradation of galactosylceramide in living cells

AbstractIn loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original prosaposin-deficient patients had a markedly reduced capacity to degrade galactosylceramide. The hydrolysis of galactosylceramide could be partially restored in these cells, up to about half the normal rate, by adding pure saposin A, pure saposin C, or a mixture of these saposins to the culture medium. By contrast, saposins B and D had little effect on galactosylceramide hydrolysis in the prosaposin-deficient cells. Cells from β-galactocerebrosidase-deficient (Krabbe) patients had a relatively high residual galactosylceramide degradation, which was similar to the rate observed for prosaposin-deficient cells in the presence of saposin A or C. An SV40-transformed fibroblast line from the original saposin C-deficient patient, where saposin A is not affected, showed normal degradation of galactosylceramide. The findings support the hypothesis, which was deduced originally from in vitro experiments, that saposins A and C are the in vivo activators of galactosylceramide degradation. Although the results with saposin C-deficient fibroblasts suggest that the presence of only saposin A allows galactosylceramide breakdown to proceed at a normal rate in fibroblasts, it remains to be determined whether saposins A and C can substitute for each other with respect to their effects on galactosylceramide metabolism in the whole organism