The phantom of Palais Brongniart economic patriotism and the Paris stock exchange

French governments are famous for promoting national champions, notably by preventing foreign takeovers, but in 2005-2006, the Villepin administration allowed the New York Stock Exchange to take control of Euronext, a French-led pan-European company that includes the Paris Bourse. By mapping the public discourse surrounding this striking case of non-intervention, we explain why opponents of the transatlantic merger failed in their appeals to economic patriotism. Discursive strategies designed to justify discrimination against territorially defined outsiders ran into several hurdles, including weak patriotic sentiments for the company concerned; a lack of patriotic alternatives to the proposed merger; and the questionable patriotic credentials of those demanding intervention. Our findings advance research on the demand side of economic patriotism including its discursive dimension. Beyond that, they inform research on business-government relations, and on the political implications of corporate ownership structures. -- Französische Regierungen sind eigentlich dafür bekannt, dass sie einheimische Unternehmen vor Auslandsübernahmen schützen. Im Jahr 2005-2006 gestattete Villepins Regierung jedoch der New York Stock Exchange die Übernahme von Euronext, einer paneuropäischen Gesellschaft unter französischer Leitung, zu der auch die Pariser Börse gehört. Der öffentliche Diskurs zu diesem bedeutenden Fall von Nichtintervention gibt Aufschluss darüber, warum die Gegner der transatlantischen Fusion mit ihren Forderungen nach Wirtschaftspatriotismus scheiterten. Diskursiven Strategien zur Rechtfertigung von Diskriminierung gegen territorial definierte Außenseiter standen mehrere Hindernisse im Weg, etwa unzureichend ausgeprägte patriotische Gefühle für den Übernahmekandidaten, der Mangel patriotischer Alternativen zu einer transatlantischen Fusion und die mangelnde patriotische Glaubwürdigkeit derer, die eine staatliche Einmischung forderten. Der vorliegende Aufsatz ergänzt mit seinem diskursiven Schwerpunkt die aktuelle Forschung zu Wirtschaftspatriotismus. Außerdem trägt er zur Forschung über die Beziehungen zwischen Staat und Unternehmen und über die politischen Auswirkungen von Veränderungen in der Struktur von Unternehmenseigentum bei.

Insiders, outsiders and the politics of corporate governance: how ownership shapes party positions in Britain, Germany and France

Dieses Papier argumentiert, dass Unterschiede in der Streuung von Unternehmensbesitz miterklären, warum Parteipositionen zum Thema Corporate Governance in verschiedenen Ländern und über Zeit stark variieren. Meist wird davon ausgegangen, dass Links/Rechts-Konflikte Kapital und Arbeit gegenüberstellen. Dabei wird übersehen, dass „Kapital“ in Bezug auf Unternehmenskontrolle kein homogenes Ganzes ist. Zwei Gruppen mit divergierenden Interessen müssen unterschieden werden: „Insiders“, die ein direktes Mitspracherecht in der Unternehmensführung haben, und „Outsiders“, die indirekt Kontrolle ausüben, indem sie mit Ausstieg drohen. Parteipositionen unterscheiden sich mit dem Größenverhältnis der Insider- und Outsider-Gruppen, die wiederum von der Struktur des Unternehmenseigentums abhängt. Das Papier stützt sich auf politische Debatten zur Übernahmeregulierung in Großbritannien, Deutschland und Frankreich seit den 1950er-Jahren. Es leistet einen Beitrag zur Forschung über Parteienwettbewerb, Corporate Governance, Spielarten des Kapitalismus und institutionellen Wandel. [Autorenreferat]This paper argues that differences in the dispersion of corporate ownership can help explain why party positions on corporate governance vary across countries and over time. Expectations that left/right conflicts should pitch capital against labor overlook that “capital” is not a homogenous constituency with regard to corporate governance issues. Two segments of capital with diverging interests need to be distinguished: “insiders” with voice over company management, and “outsiders” who exercise arms-length control by threatening exit. Party positions depend on the relative size of the insider and outsider constituencies, which in turn depends on countries’ prevailing structure of corporate ownership. The paper draws on evidence from British, German and French political debates over takeover regulation from the 1950s onward. It speaks to the literatures on party competition, corporate governance, Varieties of Capitalism and institutional change. [author's abstract

What a Difference a Zoom Makes: Intercultural Interactions Between Host and International Students

International students contribute to the academic and cultural life of universities yet often face discrimination and isolation. Studies highlight that support from the host students can make the difference between an easy or difficult transition. This article is part of a larger project about host student perceptions of international students. Initial analysis indicated that social interactions among international and host students do not become intertwined informally and work best through planned interventions. During the pandemic institutions transitioned from face-to-face to online learning using zoom. We noticed a marked increase in interaction among students online and returned to our research participants to enquire what differences online learning had made to their intercultural experiences. This study focuses on the impact of Virtual Classrooms (VCs) on intercultural relationships, and shows that Zoom offers a platform for increased interaction than face-to-face classrooms

Weight status of children aged 2-5 years old, attending a paediatric outpatient clinic and its association with parental feeding style and parental perceptions of weight status

Background: A child’s weight status can allow health care professionals to assess their developmental growth. A child having a low or high weight for height could be due to an imbalance in nutrient intake occurring. It is important to balance dietary intake and physical activity to maintain a healthy weight status. Excessive consumption of food can lead to an overweight/obese weight status which is linked to non-communicable diseases. Parental feeding style can directly impact a child’s set of eating behaviours. Therefore, parents have a strong influence over a child’s growth pattern. In addition, parental awareness of childhood obesity is reported to be poor which could be a barrier to interventions. Aim: To determine; (1) the weight status of children aged 2-5 years attending Sligo University Hospital (SUH); (2) current parental feeding styles being utilised; (3) whether parents were able to correctly classify their own weight status and that of their child and if this was associated with parental misclassification of their own weight status and (4) whether parents are interested in further information in this area, and what form this information/guidance should take. Method: A cross-sectional study was conducted in a paediatric outpatient department between September 2018 and May 2019. Data collected included anthropometric measurements and demographic information as well as a validated parental feeding style questionnaire. Data analysis was conducted using SPSS version 24. Statistical significance was set at p \u3c.05. Results: Fifty parents and children were recruited. 72% of children were classified as having a normal weight status, 22% an overweight status and 6% an obese weight status. No parent correctly classified a child as having an overweight status. No association was found between parental misclassification of a child’s weight status and their own weight status. The majority of parents used an encouragement feeding style. 84% of parents reported to be interested in obtaining healthy lifestyle information. The preferred method of receiving this information is in the form of a leaflet. Discussion/Conclusion: The childhood overweight and obesity rates within this cohort are slightly above the national rates for childhood obesity. Parental awareness of childhood overweight/obesity was found to be poor as illustrated in previous studies. Interventions need to be implemented to improve parental classification of a child’s weight status. Parents expressed an interest in receiving health education material in this setting

Early initiation of antiretroviral therapy and associated reduction in mortality, morbidity and defaulting in a nurse-managed, community cohort in Lesotho.

INTRODUCTION: The latest WHO guidelines recommend initiating antiretroviral therapy (ART) at CD4 cell counts less than 350 cells/μl. However, donors and national governments are reluctant to support implementation owing to uncertainty regarding feasibility and relative benefit. Lesotho has supported earlier initiation since 2008. We assessed outcomes comparing early (CD4 cell counts >200 cells/μl) and late (CD4 cell counts ≤200 cells/μl) initiation. METHODS: We describe survival probability among patients initiating ART at CD4 cell counts 200 or less and more than 200 cells/μl and assess associations between baseline CD4 cell counts and mortality, morbidity, loss to follow-up and hospitalization using Cox regression adjusting for confounders identified a priori. RESULTS: Our analysis included 1177 patients; median age was 38 years and the majority (67%) were women. Median time on ART for the overall cohort was 506 days (interquartile range 396-608). Five hundred and thirty eight patients initiated ART at a CD4 cell count 200 cells/μl or less (interquartile range 54-160) and 639 patients initiated at CD4 cell count more than 200 cells/μl (interquartile range 238-321). In multivariate analysis, we found that patients initiating at CD4 cell count more than 200 cells/μl were 68% less likely to die (adjusted hazard ratio 0.32, 95% confidence interval 0.20-0.50), and 39% less likely to be lost to follow-up (adjusted hazard ratio 0.61, 95% confidence interval 0.43-0.87). Initiating ART at CD4 cell count more than 200 cells/μl was also associated with a 27% reduction in the rate of incident morbidity (adjusted hazard ratio 0.73, 95% confidence interval 0.65-0.82) and a 63% decreased rate of hospitalization (adjusted hazard ratio 0.37, 95% confidence interval 0.19-0.73). CONCLUSION: Earlier initiation is feasible in a low resource, high HIV prevalence setting, and provides important benefits in terms of reduced mortality, morbidity, retention and hospitalization. Donors should fully support the implementation of the latest WHO recommendations

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy

The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies. RNA degradation and ribonucleases, such as the essential endoribonuclease RNase E, encoded by the rne gene, are emerging as potential antibacterial targets while antisense oligonucleotides may provide alternative antibacterial strategies. As rne mRNA has not been previously targeted using an antisense approach, we decided to explore using antisense oligonucleotides to target the translation initiation region of the Escherichia coli rne mRNA. Antisense oligonucleotides were rationally designed and were synthesised as locked nucleic acid (LNA) gapmers to enable inhibition of rne mRNA translation through two mechanisms. Either LNA gapmer binding could sterically block translation and/or LNA gapmer binding could facilitate RNase H-mediated cleavage of the rne mRNA. This may prove to be an advantage over the majority of previous antibacterial antisense oligonucleotide approaches which used oligonucleotide chemistries that restrict the mode-of-action of the antisense oligonucleotide to steric blocking of translation. Using an electrophoretic mobility shift assay, we demonstrate that the LNA gapmers bind to the translation initiation region of E. coli rne mRNA. We then use a cell-free transcription translation reporter assay to show that this binding is capable of inhibiting translation. Finally, in an in vitro RNase H cleavage assay, the LNA gapmers facilitate RNase H-mediated mRNA cleavage. Although the challenges of antisense oligonucleotide delivery remain to be addressed, overall, this work lays the foundations for the development of a novel antibacterial strategy targeting rne mRNA with antisense oligonucleotides

High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions

We are just beginning to unravel the myriad of interactions in which non-coding RNAs participate. The intricate RNA interactome is the foundation of many biological processes, including bacterial virulence and human disease, and represents unexploited resources for the development of potential therapeutic interventions. However, identifying specific associations of a given RNA from the multitude of possible binding partners within the cell requires robust high-throughput systems for their rapid screening. Here, we present the first demonstration of functional-RNA arrays as a novel platform technology designed for the study of such interactions using immobilized, active RNAs. We have generated high-density RNA arrays by an innovative method involving surface-capture of in vitro transcribed RNAs. This approach has significant advantages over existing technologies, particularly in its versatility in regards to binding partner character. Indeed, proof-of-principle application of RNA arrays to both RNA-small molecule and RNA-RNA pairings is demonstrated, highlighting their potential as a platform technology for mapping RNA-based networks and for pharmaceutical screening. Furthermore, the simplicity of the method supports greater user-accessibility over currently available technologies. We anticipate that functional-RNA arrays will find broad utility in the expanding field of RNA characterization

Risk Factors for Congenital Heart Disease: the Baby Hearts Study, a population-based case-control study

We investigated the role of maternal environmental factors in the aetiology of congenital heart disease (CHD). A population-based case-control study (242 CHD cases, 966 controls) was conducted using an iPad questionnaire for mother with linkage to maternity and first trimester prescription records. Risk of CHD was associated with low maternal education (OR adjusted for confounders 1.59; 95% confidence interval [CI], 1.02-2.49), pregestational diabetes (OR 4.04; 95% CI 1.00-16.28), self-reported maternal clotting disorders (adjOR 8.55, 95%CI 1.51-48.44), prescriptions for the anticlotting medication enoxaparin (adjOR 3.22, 95%CI 1.01-10.22) and self-reported vaginal infections (adjOR 1.69, 95%CI 1.01-2.80). There was no strong support for the hypothesis that periconceptional folic acid supplements have a protective effect, but there was a protective effect of frequent consumption of folate rich fruits (adjOR 0.64, 95%CI 0.47-0.89). Compared to the most common pre-pregnancy dietary pattern, CHD risk was associated with a poor diet low in fruit and vegetables (adjOR 1.56, 95%CI 1.05-2.34). Mothers of cases reported more pregnancy related stress (adjOR 1.69; 95% CI 1.22-2.34) and multiple stressors (adjOR 1.94, 95%CI 0.83-4.53). We found no supportive evidence for CHD risk being associated with obesity, smoking, depression or antidepressant use in this population. Our findings add to the previous evidence base to show potential for public health approaches to help prevent CHD in future by modifying environmental factors. Independent confirmation should be sought regarding elevated CHD risk associated with maternal blood clotting disorders and their treatment, since we are the first to report this