Surgical clipping compared to endovascular coiling of ruptured coil able middle cerebral aneurysms: A single-center experience

Objective: The middle cerebral artery (MCA) is the third most common site for ruptured intracranial aneurysms. Aneurysms in this location are known to be challenging to treat endovascularly and are commonly treated with microsurgery. Although advances in endovascular treatment options for cerebral aneurysms have markedly reduced the need for surgery in recent years and decades, there is no compelling scientific evidence that endovascular treatments are superior to surgical treatment. The present study aimed to determine the appropriate treatment modality in ruptured MCA aneurysms. Methods: We retrospectively evaluated and compared the treatment outcomes of 80 patients with ruptured MCA aneurysms who underwent either endovascular or microsurgical treatment in our center between 2011 and 2016. Post-treatment clinical and radiological outcomes were assessed in all patients. Furthermore, we compared intraoperative complications and the need for re-treatments between the two groups. Results: According to our findings, complete aneurysm occlusion was achieved in 90.5 and 89.2 of the patients in the clipping and coil group, respectively (p = 0.850). Moreover, 14.3 of the patients in the clipping group and 15.8 of the subjects in the coil group developed intraoperative complications (p = 0.851), including 3 cases of intraoperative hemorrhage and 3 cases of ischemia in the clipping group as well as 2 cases of thromboembolism and 4 cases of vasospasm during endovascular treatment in the coil group. There was an improvement in the modified Rankin score (mRS) at six months, with no significant difference between the two groups (p = 0.916). Conclusion: The results of coiling only with coil able MCA aneurysms were comparable to the results of clipping with difficult cases. Sufficient follow-up study of recurrence and retreatment are needed to determine the indication for coiling for ruptured MCA aneurysm. © 202

Modeling of mass transfer enhancement in a magnetofluidic micromixer

© 2019 Author(s). The use of magnetism for various microfluidic functions such as separation, mixing, and pumping has been attracting great interest from the research community as this concept is simple, effective, and of low cost. Magnetic control avoids common problems of active microfluidic manipulation such as heat, surface charge, and high ionic concentration. The majority of past works on micromagnetofluidic devices were experimental, and a comprehensive numerical model to simulate the fundamental transport phenomena in these devices is still lacking. The present study aims to develop a numerical model to simulate transport phenomena in microfluidic devices with ferrofluid and fluorescent dye induced by a nonuniform magnetic field. The numerical results were validated by experimental data from our previous work, indicating a significant increase in mass transfer. The model shows a reasonable agreement with experimental data for the concentration distribution of both magnetic and nonmagnetic species. Magnetoconvective secondary flow enhances the transport of nonmagnetic fluorescent dye. A subsequent parametric analysis investigated the effect of the magnetic field strength and nanoparticle size on the mass transfer process. Mass transport of the fluorescent dye is enhanced with increasing field strength and size of magnetic particles