12 research outputs found
B-aminoisobutyric Acid Relates to Favorable Glucose Metabolism and Adiponectin in Adults with Metabolic Syndrome
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Early Chronotype Favors Appetite and Reduced Later Day Caloric Intake Among Adults with Metabolic Syndrome
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Roel of Morning versus Evening Chronotype on Insulin Sensitivity and Central Hemodynamics in Adults with Metabolic Syndrome
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Reduced Aortic Waveform Responses to Insulin in Late Chronotype with Metabolic Syndrome
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Effect of Late versus Early Chronotype on Fuel Metabolism During Exercise
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Aortic waveform responses to insulin in late versus early chronotype with metabolic syndrome
Abstract Late chronotype (LC) correlates with reduced metabolic insulin sensitivity and cardiovascular disease. It is unclear if insulin action on aortic waveforms and inflammation is altered in LC versus early chronotype (EC). Adults with metabolic syndrome (n = 39, MetS) were classified as either EC (MorningâEveningness Questionnaire [MEQ] = 63.5â±â1.2) or LC (MEQ = 45.5â±â1.3). A 120âmin euglycemic clamp (40âmU/m2/min, 90âmg/dL) with indirect calorimetry was used to determine metabolic insulin sensitivity (glucose infusion rate [GIR]) and nonoxidative glucose disposal (NOGD). Aortic waveforms via applanation tonometry and inflammation by blood biochemistries were assessed at 0 and 120âmin of the clamp. LC had higher fatâfree mass and lower VO2max, GIR, and NOGD (between groups, all pââ€â0.05) than EC. Despite no difference in 0 min waveforms, both groups had insulinâstimulated elevations in pulse pressure amplification with reduced AIx75 and augmentation pressure (AP; time effect, pââ€â0.05). However, EC had decreased forward pressure (Pf; interaction effect, p = 0.007) with insulin versus rises in LC. Although LC had higher tumor necrosis factorâα (TNFâα; group effect, pââ€â0.01) than EC, both LC and EC had insulinâstimulated increases in TNFâα and decreases in hsâCRP (time effect, both pââ€â0.01). Higher MEQ scores related to greater insulinâstimulated reductions in AP (r = â0.42, p = 0.016) and Pf (r = â0.41, p = 0.02). VO2max correlated with insulinâmediated reductions in AIx75 (r = â0.56, pâ<â0.01) and AP (r = â0.49, pâ<â0.01). NOGD related to decreased AP (r = â0.44, p = 0.03) and Pf (r = â0.43, p = 0.04) during insulin infusion. LC was depicted by blunted forward pressure waveform responses to insulin and higher TNFâα in MetS. More work is needed to assess endothelial function across chronotypes
Effect of Chronotype on Non-Exercise Physical Activity Patterns and Metabolic Insulin Sensitivity
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Light Physical Activity Relates to Insulin Sensitivity and Earlier Time of Day in Metabolic Syndrome
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