Characteristics of Foreign R&D Strategies of Swiss Firms: Implications for Policy

The aim of the paper is, firstly, to identify a number of strategies Swiss firms pursue by performing foreign R&D, expecting that firms, in many instances, are driven by a combination of several motives (mixed strategies). Secondly, we ask whether foreign and domestic R&D are substitutes or complements. Thirdly, we draw some policy conclusions based on results for direct and indirect home-country effects of foreign R&D. By applying cluster analysis, we identified four specific patterns of motives of foreign R&D. In a second step, we investigated whether these clusters effectively may be interpreted as specific types of R&D strategies. To this end, the clusters were characterised in terms of a large number of variables, which, according to the OLI paradigm of FDI, determine foreign R&D. We found that the patterns of the four clusters systematically differ with respect to these theory-related variables. Some clusters represent, in terms of motives, broad-based mixed strategies, whereas others are strongly focused. It turns out that foreign R&D strategies that primarily aim at exploiting capabilities of the domestic headquarters dominate, whereas cost-reducing strategies are of very minor importance. In case of the other two strategies knowledge sourcing is a constituent element, in the first one, knowledge sourcing is at the core, in the second case it is an important element in the frame of a broad-based strategy. The relative importance of the four strategies implies that, on balance, foreign and domestic R&D are complements. Notwithstanding this positive result, it is sensible to take policy actions supporting the economy to capitalise even more on outward FDI in R&D. Policy basically should aim at securing the attractiveness of Switzerland as a location for R&D-intensive headquarters of firms performing foreign R&D, and at enhancing knowledge spillovers from headquarter companies to other domestic firms. The five categories of measures we recommend are part of a framework-oriented policy design rather than of a more interventionist concept.Internationalisation of R&D; Motives of foreign R&D; Foreign R&D strategies; Knowledge spillovers; Home-country effects of outward FDI in R&D

The palaeoceanography of the Leeuwin Current : implications for a future world

Long-term progressive changes of the Leeuwin Current are linked to plate and ocean basin ‘geography’ and Cenozoic global climates and palaeoceanography. Suggestions of the presence of a proto-Leeuwin Current as early as late Middle to Late Eocene times (c. 35–42 Ma) cannot be verified by the fossil record of the western margin of Australia. “Leeuwin Current style” circulation around Australia was certainly established by the early Oligocene, in response to palaeogeographic changes in the Tasman Strait. This, followed by tectonic eorganisation of the Indonesian Archipelago throughout the Miocene, provided a palaeogeographic setting, which by the Pliocene was essentially that of today. The subsequent history of the Leeuwin Current comprises climatically-induced changes operating over orbital and sub-orbital temporal scales. Specifically, the advent of Pleistocene-style climates, especially over the last 800 000 years, and their associated interglacial – glacial states provide the two end-member climate-ocean states that have characterised Leeuwin Current activity during that time. Indications of the nature of these contrasting states is provided by: (i) the Last Interglacial (c. 125 Ka) during which sea level was higher by some +4 m, and with higher sea surface temperatures (SSTs) clearly indicating a more ‘active’ Leeuwin Current; and (ii) the Last Glacial Maximum (21 Ka), during which sea level wassome 130 m lower than today, resulting in massive shelf extensions along the coast of Western Australia, ccompanied by reduced Indonesian Throughflow, lower low latitude SSTs and changes in the Western Pacific Warm Water Pool, and with these changes, possibly reduced Leeuwin Current activity. Sub-orbital scale luctuations in current strength are driven by global climate change associated with El Niño – La Niña events as well as regional climatic changes driven by volcanism. These forcing mechanisms operate at time scales well within the reach of human experience, and provide important comparative data for predicting the response of the Leeuwin Current to climate change predicted for this century. Studies of the impact of changes in the vigour of the Leeuwin Current on shallow marine communities are in their infancy. Coupling climate models with geological analogues provide important research agenda for predicting the trajectory of future changes to the Leeuwin Current and their impacts on the marine biota of coastal Western Australia

Long Term Trends in Resource Exergy Consumption and Useful Work Supplies in the UK, 1900-2000

Our aim is to explain historical economic growth in the UK economy by introducing an empirical measure for useful work derived from natural resource energy inputs into an augmented production function. To do this, we estimate the long-term (1900-2000) trends in resource exergy supply and conversion to useful work in the United Kingdom. The exergy resources considered included domestic consumption of coal, crude oil and petroleum products, natural gas, nuclear and renewable resources (including biomass). All flows of exergy were allocated to an end use such as providing heat, light, transport, human and animal work and electrical power. For each end-use we estimated a time dependent efficiency of conversion from exergy to useful work. The 3-factor production function (of capital, labour and useful work) is able to reproduce the historic trajectory of economic growth without recourse to any exogenous assumptions of technological progress or total factor productivity. The results indicate that useful work derived from natural resource exergy is an important factor of production.exergy, energy, efficiency, economic growth, United Kingdom

Characteristics of Foreign R&D Strategies of Swiss Firms: Implications for Policy

The aim of the paper is, firstly, to identify a number of strategies Swiss firms pursue by performing foreign R&D, expecting that firms, in many instances, are driven by a combination of several motives (mixed strategies). Secondly, we ask whether foreign and domestic R&D are substitutes or complements. Thirdly, we draw some policy conclusions based on results for direct and indirect home-country effects of foreign R&D. By applying cluster analysis, we identified four specific patterns of motives of foreign R&D. In a second step, we investigated whether these clusters effectively may be interpreted as specific types of R&D strategies. To this end, the clusters were characterised in terms of a large number of variables, which, according to the OLI paradigm of FDI, determine foreign R&D. We found that the patterns of the four clusters systematically differ with respect to these theory-related variables. Some clusters represent, in terms of motives, broad-based mixed strategies, whereas others are strongly focused. It turns out that foreign R&D strategies that primarily aim at exploiting capabilities of the domestic headquarters dominate, whereas cost-reducing strategies are of very minor importance. In case of the other two strategies knowledge sourcing is a constituent element, in the first one, knowledge sourcing is at the core, in the second case it is an important element in the frame of a broad-based strategy. The relative importance of the four strategies implies that, on balance, foreign and domestic R&D are complements. Notwithstanding this positive result, it is sensible to take policy actions supporting the economy to capitalise even more on outward FDI in R&D. Policy basically should aim at securing the attractiveness of Switzerland as a location for R&D-intensive headquarters of firms performing foreign R&D, and at enhancing knowledge spillovers from headquarter companies to other domestic firms. The five categories of measures we recommend are part of a framework-oriented policy design rather than of a more interventionist concept

From Understanding Genetic Drift to a Smart-Restart Parameter-less Compact Genetic Algorithm

One of the key difficulties in using estimation-of-distribution algorithms is choosing the population size(s) appropriately: Too small values lead to genetic drift, which can cause enormous difficulties. In the regime with no genetic drift, however, often the runtime is roughly proportional to the population size, which renders large population sizes inefficient. Based on a recent quantitative analysis which population sizes lead to genetic drift, we propose a parameter-less version of the compact genetic algorithm that automatically finds a suitable population size without spending too much time in situations unfavorable due to genetic drift. We prove a mathematical runtime guarantee for this algorithm and conduct an extensive experimental analysis on four classic benchmark problems both without and with additive centered Gaussian posterior noise. The former shows that under a natural assumption, our algorithm has a performance very similar to the one obtainable from the best problem-specific population size. The latter confirms that missing the right population size in the original cGA can be detrimental and that previous theory-based suggestions for the population size can be far away from the right values; it also shows that our algorithm as well as a previously proposed parameter-less variant of the cGA based on parallel runs avoid such pitfalls. Comparing the two parameter-less approaches, ours profits from its ability to abort runs which are likely to be stuck in a genetic drift situation.Comment: 4 figures. Extended version of a paper appearing at GECCO 202

Regioselective Magnesiation and Zincation Reactions of Aromatics and Heterocycles Triggered by Lewis Acids

Mixed TMP‐bases (TMP=2,2,6,6‐tetramethylpiperidyl), such as TMPMgCl ⋅ LiCl, TMP(2)Mg ⋅ 2LiCl, TMPZnCl ⋅ LiCl and TMP(2)Zn ⋅ 2LiCl, are outstanding reagents for the metalation of functionalized aromatics and heterocycles. In the presence of Lewis acids, such as BF(3) ⋅ OEt(2) or MgCl(2), the metalation scope of such bases was dramatically increased, and regioselectivity switches were achieved in the presence or absence of these Lewis acids. Furthermore, highly reactive lithium bases, such as TMPLi or Cy(2)NLi, are also compatible with various Lewis acids, such as MgCl(2) ⋅ 2LiCl, ZnCl(2) ⋅ 2LiCl or CuCN ⋅ 2LiCl. Performing such metalations in continuous flow using commercial setups permitted practical and convenient reaction conditions

Loosely coherent search in LIGO O1 data for continuous gravitational waves from Terzan 5 and the galactic center

We report results of a search for continuous gravitational waves from a region covering the globular cluster Terzan 5 and the galactic center. Continuous gravitational waves are expected from fast-spinning, slightly non-axisymmetric isolated neutron stars as well as more exotic objects. The regions that we target are believed to be unusually abundant in neutron stars. We use a new loosely coherent search method that allows to reach unprecedented levels of sensitivity for this type of search. The search covers the frequency band 475-1500 Hz and frequency time derivatives in the range of [-3e-8, +1e-9] Hz/s, which is a parameter range not explored before with the depth reached by this search. As to be expected with only a few months of data from the same observing run, it is very difficult to make a confident detection of a continuous signal over such a large parameter space. A list of parameter space points that passed all the thresholds of this search is provided. We follow-up the most significant outlier on the newly released O2 data and cannot confirm it. We provide upper limits on the gravitational wave strength of signals as a function of signal frequency