Antidepressant Use During Acute Inpatient Care Is Associated With an Increased Risk of Psychiatric Rehospitalisation Over a 12-Month Follow-Up After Discharge

Background: Some evidence suggests that antidepressants may relate to poor outcomes in depression. The aim of this study was, therefore, to examine, whether antidepressant use may worsen the long-term outcome in real-world psychiatric patients with both primarily affective and non-affective mental disorders.Methods: Based on a total of n = 151 inpatients with a mixed range of diagnoses enrolled at two psychiatric hospitals in Zurich, Switzerland, matched pairs of n = 45 antidepressant users and n = 45 non-users were selected via nearest neighbor propensity score matching. Pairs were matched according to 14 clinically relevant covariates assessing psychosocial impairments, functioning deficits and illness severity. The two outcomes of interest were the number and total duration of all rehospitalisations over a 12-month follow-up after discharge from the hospital based on the official clinical registry.Results: Altogether 35.6% of antidepressant users were rehospitalised at least once, as compared to 22.2% in matched non-users. Two or more rehospitalisations occurred in 22.2% of antidepressant users but only in 2.2% of non-users. In antidepressant users, the mean total duration of rehospitalisations was 22.22 days, as compared to 8.51 in matched non-users. According to Poisson regression analyses, antidepressant use during acute inpatient care prospectively relates to both a higher risk (incidence rate ratio [IRR] = 3.64, 95% confidence interval [95%-CI] = 1.71–7.75, p = 0.001) and a longer duration (IRR = 2.61, 95%-CI = 1.01–6.79, p = 0.049) of subsequent rehospitalisations. These findings were consistently replicated when traditional multivariable regression analysis was applied to the full sample. Findings also replicated when patients with affective and non-affective disorders were analyzed separately.Conclusions: Our findings raise the possibility that, in the long-term, antidepressants may impair recovery and increase the risk of rehospitalisation in patients with both primarily affective and non-affective disorders. More work is required to explore possible aetiopathological pathways leading to psychiatric rehospitalisation

Observation of a new ηπ0π0\mathrm{\eta \pi^0\pi^0} resonance at 1900 MeV/c2\mathrm{MeV/c^2} in two-photon scattering

Using the Crystal Ball detector at the DORIS II $e^+e^−$ storage ring, we measure the $ηπ^0π^0$ mass spectrum in the reaction $e^+e^−→e^+e^−ηπ^0π^0→e^+e^−6γ$ from the ηπ0π0 threshold to about 2500 MeV/c$^2$. The spectrum is dominated by the η′, for which we determine $Γγγ(η′)BR(η'→6γ)=0.36±0.02±0.03$ keV. In addition, we observe an enhancement in the cross section near 1900 MeV/c$^2$ which we attribute to the two-photon production of a new resonance X(1900). The angular distributions and the invariant mass distribution of the ηπ0 subsystem are consistent with those expected for the hypothetical η2 meson with $JPC=2\pm$. For this JP assignment the resonance parameters are M(X) = 1876 ±35±50 MeV/c$^2$, Γtot(X)=228±90±34 MeV/c$^2$ and $Γγγ(X)BR(X→ηππ) = 0.9±0.2±0.3$ keV

Observation of a new eta pi0 pi0 resonance at 1900 MeV/c^2 in two-photon scattering

Using the Crystal Ball detector at the DORIS II e+e- storage ring, we measure the ηπ 0π 0 mass spectrum in the reaction e+e- -> e+e- eta pi0 pi0 -> e+e- 6gamma from the eta pi0 pi0 threshold to about 2500 MeV/c 2. The spectrum is dominated by the eta′, for which we determine Gamma(gamma gamma)(eta') BR(eta' -> 6 gamma)=0. 36+-0.02+-0.03 keV. In addition, we observe an enhancement in the cross section near 1900 MeV/c 2 which we attribute to the two-photon production of a new resonance X(1900). The angular distributions and the invariant mass distribution of the eta pi0 subsystem are consistent with those expected for the hypothetical eta2 meson with J(PC)=2(-+). For this J(P) assignment the resonance parameters are M(X)=1876+-35+-50 MeV/c 2, Gamma-tot(X)=228+-90+-34 MeV/c 2 and Gamma(gamma gamma)(X) BR(X -> eta pi pi)=0.9+-0.2+-0.3 keV

First observation of the reaction γγ→π2→π0π0π0\gamma \gamma \to \pi_2 \to \pi^0 \pi^0 \pi^0

The Crystal Ball detector has been used at the DORIS II storage ring at DESY to study the reactionγγ→π0π0π0 in theπ0π0π0 invariant mass range from 850 MeV/c2 to 2600 MeV/c2. An enhancement around 1750 MeV/c2 is attributed to theπ2(1670) resonance. The observedπ0π0 invariant mass distribution and theπ0 angular distributions are consistent with those expected for the decay chainπ2→π0f2(1270)→π0π0π0. From our measurements we find the following resonance parameters: two photon partial width$\Gamma _{\pi _2 }^{\gamma \gamma }= (1.41 \pm 0.23 \pm 0.28)keV$, massM(π2)=(1742±31±49)MeV/c2. and total width$\Gamma _{\pi _2 }^{tot}= (236 \pm 49 \pm 36)MeV$

Limits on axion and light Higgs boson production in Υ(1S)\Upsilon (1S) decays

We have searched for axion and light Higgs boson production in the channel $ϒ (1S)$ → $(a^0 or h^0) + γ$, where the non-interacting axion a0 and the Higgs boson $h^0$ do not decay in the detector. We find no evidence for an axion and give an upper limit,$Br(ϒ (1S) → a^0γ) < 4.0 × 10^{−5} (90$, for long-lived axions. Combining our limit with the previous search in J/ψ decays, we are able to rule out the axion in the standard model with first order QCD corrections. Our $ϒ (1S)$ data also rule out a Higgs boson with mass mh < 86 MeV

Determination of Γee\Gamma_{ee} of the Υ\Upsilon (1S) and Υ\Upsilon (2S) Resonances and Measurement of R at W=9.39 GeV

Using the Crystal Ball detector operating at the DORIS II storage ring we have measured the leptonic partial widthsГeeof the Υ(1S) and Υ(2S) reso

Limits on axion and light Higgs boson production in Υ(1S)\Upsilon (1S) decays

We have searched for axion and light Higgs boson production in the channel $ϒ (1S)$ → $(a^0 or h^0) + γ$, where the non-interacting axion a0 and the Higgs boson $h^0$ do not decay in the detector. We find no evidence for an axion and give an upper limit,$Br(ϒ (1S) → a^0γ) < 4.0 × 10^{−5} (90$, for long-lived axions. Combining our limit with the previous search in J/ψ decays, we are able to rule out the axion in the standard model with first order QCD corrections. Our $ϒ (1S)$ data also rule out a Higgs boson with mass mh < 86 MeV

Hyperon signatures in the PANDA experiment at FAIR

We present a detailed simulation study of the signatures from the sequential decays of the triple-strange pbar p -> Ω+Ω- -> K+ΛbarK- Λ -> K+pbarπ+K-pπ- process in the PANDA central tracking system with focus on hit patterns and precise time measurement. We present a systematic approach for studying physics channels at the detector level and develop input criteria for tracking algorithms and trigger lines. Finally, we study the beam momentum dependence on the reconstruction efficiency for the PANDA detector