58 research outputs found

    Studies of azimuthal dihadron correlations in ultra-central PbPb collisions at=2.76 TeV

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    Observation of a peaking structure in the J/psi phi mass spectrum from B(+/-) to J/psi phi K(+/-) decays

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    Measurement of the production cross section for a W boson and two b jets in pp collisions at root s=7 TeV

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    The production cross section for a W boson and two b jets is measured using proton&#8211;proton collisions at s=7 TeV in a data sample collected with the CMS experiment at the LHC corresponding to an integrated luminosity of 5.0 fb &#8722;1 . The W+bb¯ events are selected in the W&#8594;&#956;&#957; decay mode by requiring a muon with transverse momentum pT>25 GeV and pseudorapidity |&#951;|25 GeV and |&#951;|<2.4 . The measured W+bb¯ production cross section in the fiducial region, calculated at the level of final-state particles, is &#963;(pp&#8594;W+bb¯)×B(W&#8594;&#956;&#957;)=0.53±0.05(stat.)±0.09(syst.)±0.06(theo.)±0.01(lum.) pb , in agreement with the standard model prediction. In addition, kinematic distributions of the W+bb¯ system are in agreement with the predictions of a simulation using MadGraph and pythia

    Searches for light- and heavy-flavour three-jet resonances in pp collisions at root s=8 TeV

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    Measurement of the top-quark mass in all-jets tt events in pp collisions at root = 7 TeV

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    The mass of the top quark is measured using a sample of tt¯ candidate events with at least six jets in the final state. The sample is selected from data collected with the CMS detector in pp collisions at s&#8730;=7 TeV in 2011 and corresponds to an integrated luminosity of 3.54 fb&#8722;1 . The mass is reconstructed for each event employing a kinematic fit of the jets to a tt¯ hypothesis. The top-quark mass is measured to be 173.49±0.69(stat.)±1.21(syst.) GeV. A combination with previously published measurements in other decay modes by CMS yields a mass of 173.54±0.33(stat.)±0.96(syst.) GeV

    Stem cell therapy for white matter disorders: don't forget the microenvironment!

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    Intraneuronal tau pathology induces cellular stress in astrocytes in human co-culture

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    BACKGROUND: Tau aggregation is the major pathological hallmark of neurodegenerative tauopathies and strongly correlates with neurodegeneration. Yet, the mechanism by which tau pathology leads to neuronal dysfunction and how astrocytes contribute to disease pathogenesis is largely elusive, partly due to the lack of suitable human co-culture models. METHOD: We established a novel human neuron/astrocyte co-culture model in 96-well format, compatible with high-content automated microscopy analysis. Ngn2-iPSC differentiated neurons and primary human astrocytes were used in combination with a spontaneously aggregating tau variant. RESULT: Neurons with a morphologically mature synapse pattern were obtained within 4 weeks. Introduction of a spontaneously aggregating tau variant induces progressive intraneuronal accumulation of pathologically phosphorylated, insoluble tau. Intraneuronal tau accumulation progressively induces oxidative stress and activation of the integrated stress response in co-cultured human astrocytes. CONCLUSION: This novel human co-culture model recapitulates key features of human tau pathology and enables the identification of cell autonomous and non-autonomous disease mechanisms, giving a unique opportunity for future target identification and intervention studies in a translationally relevant in vitro context

    Leukodystrophies: Five new things.

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