Patients`demographics and preoperative antithrombotic medication.

<p>BMI indicates body mass index. Data are numbers (percent), mean ± standard deviation or median with interquartile ranges [25q;75q] where appropriate.</p><p>Patients`demographics and preoperative antithrombotic medication.</p

Clauss fibrinogen and A10 in relation to CPB.

<p>Boxplot, median, 25^th/75^th percentile; whiskers, 10^th/90^th percentile; extremes. A10, A10. *) denotes significant (p < 0.05) change between times of measurement.</p

Relationship and correlation estimates between on-CPB and post-CPB levels of Clauss fibrinogen (A), A10 (B) and MCF (C) with corresponding Bland-Altman plot.

<p>CPB, cardiopulmonary bypass; FIBTEM A10, A10; MCF, maximum clot firmness.</p

Relationship between Clauss fibrinogen and A10 according to operative period and mean hemoglobin.

<p>Regression analysis. Equation: Polynomial, linear. Blue lines = 95% Confidence Band; Red lines = 95% Prediction Band. A10, A10.</p

Percentage of error calculation.

<p>Percentage of error = 100 x 1.96 x standard deviation of the difference between the post-CPB and the on-CPB value / mean of on-CPB and post-CPB value.</p><p>Percentage of error calculation.</p

Discriminative power of FIBTEM variables for Clauss fibrinogen (A) and ROC curves at Clauss fibrinogen cutoff of 1.6 g/l (B).

<p>Red arrow = highest ROC-AUC in the recommended range for fibrinogen substitution by guidelines (blue transparent square). ROC, receiver operating characteristics.</p

Sensitivity and specificity of A10 for Clauss fibrinogen limits of ≤ 1.5 and ≤ 2.0 g/l, respectively, with optimal operating point at 10 mm (A10).

<p>Two-graph fitted ROC curves with 95% confidence interval showing sensitivity and specificity for each limit. Sensitivity (blue curve) and specificity (gray dash-dot curve) for post-CPB Clauss fibrinogen ≤1.5 g/l and sensitivity (gray dash-dot-dot curve) and specificity (green curve) for post-CPB Clauss fibrinogen >2.0 g/l. Black circles: best sensitivity and specificity for Clauss fibrinogen ≤1.5 g/l (left circle, corresponds to A10 of 6.9 mm) and for Clauss fibrinogen >2.0 g/l (right circle, corresponds to A10 of 9.0). Red cross corresponds to optimal operating point with an on-CPB A10 sensitivity for post-CPB Clauss fibrinogen ≤1.5 g/l of 0.99 and a specificity for post-CPB Clauss fibrinogen >2.0 g/l of 0.83.</p

Total reduction in lung impedance normalized for impedance amplitude at tidal volumes of 6ml.kg^-1 lean body weight at different flow rates.

No significant differences between groups.</p

Consolidated standards of reporting trials flow diagram.

Consolidated standards of reporting trials flow diagram.</p

CONSORT 2010 checklist of information to include when reporting a randomised trial*.

(DOCX)</p