Book Review: Jeffrey Hanson and Michael R. Kelly, eds. Michel Henry: The Affects of Thought

A review of Jeffrey Hanson and Michael R. Kelly, eds., Michel Henry: The Affects of Thought (London: Continuum, 2012), 177 pp

The Frobenius problem over real number fields

Given a number field $K$ that is a subfield of the real numbers, we generalize the notion of the classical Frobenius problem to the ring of integers $\mathfrak{O}_K$ of $K$ by describing certain Frobenius semigroups, $\mathrm{Frob}(\alpha_1,\dots,\alpha_n)$, for appropriate elements $\alpha_1,\dots,\alpha_n\in\mathfrak{O}_K$. We construct a partial ordering on $\mathrm{Frob}(\alpha_1,\dots,\alpha_n)$, and show that this set is completely described by the maximal elements with respect to this ordering. We also show that $\mathrm{Frob}(\alpha_1,\dots,\alpha_n)$ will always have finitely many such maximal elements, but in general, the number of maximal elements can grow without bound as $n$ is fixed and $\alpha_1,\dots,\alpha_n\in\mathfrak{O}_K$ vary. Explicit examples of the Frobenius semigroups are also calculated for certain cases in real quadratic number fields.Comment: 17 page

Lipopolysaccharide-Binding Alkylpolyamine DS-96 Inhibits Chlamydia trachomatis Infection by Blocking Attachment and Entry

This is the published version. Copyright © 2014, American Society for Microbiology. All Rights Reserved.Vaginally delivered microbicides are being developed to offer women self-initiated protection against transmission of sexually transmitted infections such as Chlamydia trachomatis. A small molecule, DS-96, rationally designed for high affinity to Escherichia coli lipid A, was previously demonstrated to bind and neutralize lipopolysaccharide (LPS) from a wide variety of Gram-negative bacteria (D. Sil et al., Antimicrob. Agents Chemother. 51:2811–2819, 2007, doi:10.1128/AAC.00200-07). Aside from the lack of the repeating O antigen, chlamydial lipooligosaccharide (LOS) shares general molecular architecture features with E. coli LPS. Importantly, the portion of lipid A where the interaction with DS-96 is expected to take place is well conserved between the two organisms, leading to the hypothesis that DS-96 inhibits Chlamydia infection by binding to LOS and compromising the function. In this study, antichlamydial activity of DS-96 was examined in cell culture. DS-96 inhibited the intercellular growth of Chlamydia in a dose-dependent manner and offered a high level of inhibition at a relatively low concentration (8 μM). The data also revealed that infectious elementary bodies (EBs) were predominantly blocked at the attachment step, as indicated by the reduced number of EBs associated with the host cell surface following pretreatment. Of those EBs that were capable of attachment, the vast majority was unable to gain entry into the host cell. Inhibition of EB attachment and entry by DS-96 suggests that Chlamydia LOS is critical to these processes during the developmental cycle. Importantly, given the low association of host toxicity previously reported by Sil et al., DS-96 is expected to perform well in animal studies as an active antichlamydial compound in a vaginal microbicide

Simple Resazurin-Based Microplate Assay for Measuring Chlamydia Infections

This is the publisher's version. Copyright 2013 by the American Society for Microbiology.The conventional method for quantification of Chlamydia infection using fluorescence microscopy typically involves time- and labor-intensive manual enumeration, which is not applicable for a large-scale analysis required for an inhibitory compound screen. In this study, an alamarBlue (resazurin) assay was adopted to measure Chlamydia infection by measuring the redox capability of infected host cells in a 96-well format. The assay provided measurements comparable to those of the conventional microscopy method while drastically reducing the time required for analysis

RANCANG BANGUN APLIKASI ROUTING MOBILE BERPLATFORM ANDROID DENGAN IMPLEMENTASI CISCO PACKET TRACER UNTUK MENINGKATKAN KOMPETENSI ROUTING STATIS (STUDI KASUS: SMK KETINTANG SURABAYA)

Tenaga pendidik menjadi yang terdepan selama diselenggarakannya pendidikan di Indonesia. Kompetensi yang dimiliki guru menjadi cerminan kemampuan guru ketika guru menjalankan tugas yang dimiliki. Terdapat dua kompetensi yang menjadi hal utama untuk dimiliki guru yaitu kompetensi pedagogik dan kompetensi profesional. Ketika terjadi perubahan kurikulum 2013 ini menyebabkan kebutuhan guru yang siap untuk mengimplementasikan di lapangan meningkat. Selain itu, kompetensi guru yang kompeten juga diperlukan sebagai kebutuhan di masa depan. Kondisi yang sebenarnya terjadi di lapangan yaitu guru di sekolah masih tidak memiliki kesesuaian kompetensi dengan mata pelajaran yang diampu. Dengan adanya masalah tersebut, dimana guru memiliki keterbatasan kompetensi maka dibutuhkan media pembelajaran aplikasi berplatform android untuk memudahkan siswa dalam memahami. Penelitian yang dilakukan menggunakan metode Research and Development untuk pengembangan aplikasi. Sedangkan, dari data yang didapatkan dari penelitian kemudian akan dikumpulkan dan dianalisis menggunakan metode kuantitaif deskriptif. Hasil validasi media pembelajaran atau aplikasi routing mobile memperoleh presentase 80% yang dikategorikan layak untuk diimplementasikan. Berdasarkan penelitian kepada peserta didik dengan diberikan pretest dan posttest memperoleh rata-rata 44.85 untuk pretest dan 79.8 untuk posttest. Maka dapat menunjukkan adanya pengaruh dan perbedaan hasil yang signifikan dari rata-rata yang didapatkan

Flexible resource use strategies of a central-place forager experiencing dynamic risk and opportunity

We used data collected from GPS loggers on golden-mantled ground squirrels (Callospermophilus lateralis) to model selection or avoidance of resources in two seasons of seed availability and one season in which no seeds were available. Movement decisions were measured in short-term discrete time intervals using high resolution location data. Selection or avoidance of specific resource features that entail fitness consequences were then assessed using resource selection functions.University of Nevada, Reno, Whittell Forest Graduate Fellowship endowed fundOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen.

Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex was shown to elicit partial protection against infection. Computational modeling of a neighboring gene revealed a novel subunit of the V-type ATPase (TC0583). To determine if this newly identified subunit could induce protection and/or enhance the partial protection provided by subunit A alone, challenge studies were performed using a combination of these recombinant proteins. The TC0583 subunit alone and concurrently with TC0582, was used to vaccinate BALB/c mice utilizing CpG-1826 and Montanide ISA 720 VG as adjuvants. Vaccinated animals were challenged intranasally with Chlamydia muridarum and the course of the infection was followed. Mice immunized with individual antigens showed minimal alleviation of body weight reduction; however, mice immunized with TC0583 and TC0582 in combination, displayed weight loss levels close to those observed with MOMP. Importantly, immunization with a combination of recombinant subunit proteins reduced chlamydial inclusion forming units by approximately a log-fold. These protection levels support that, these highly conserved Chlamydia proteins, in combination with other antigens, may serve as potential vaccine candidates

The impact of celestial pole offset modelling on VLBI UT1 Intensive results

Very Long Baseline Interferometry (VLBI) Intensive sessions are scheduled to provide operational Universal Time (UT1) determinations with low latency. UT1 estimates obtained from these observations heavily depend on the model of the celestial pole motion used during data processing. However, even the most accurate precession-nutation model, IAU 2000/2006, is not accurate enough to realize the full potential of VLBI observations. To achieve the highest possible accuracy in UT1 estimates, a celestial pole offset (CPO), which is the difference between the actual and modelled precession-nutation angles, should be applied. Three CPO models are currently available for users. In this paper, these models have been tested and the differences between UT1 estimates obtained with those models are investigated. It has been shown that neglecting CPO modelling during VLBI UT1 Intensive processing causes systematic errors in UT1 series of up to 20 microarcseconds. It has been also found that using different CPO models causes the differences in UT1 estimates reaching 10 microarcseconds. Obtained results are applicable to the satellite data processing as well.Comment: 8 pp., accepted for publication in Journal of Geodes