Understanding student resistance as a communicative act

In the current era of “zero tolerance”, disciplinary practices including punishment, expulsion, physical and psychological surveillance, and confinement, are a major part of resistant students’ lived experiences. This article is an ethnographic study of student resistance that is observed in an alternative high school in the U.S., which serves students expelled from regular schools for their acts of resistance. The purpose of this study is to explore how understanding of the meaning of student resistance can be used as a theoretical and pedagogical medium with which teachers can create an equitable, educational milieu that upholds views and experiences of the marginalized students. The study also offers a new insight into resistance theory drawing upon Dewey’s transactional theory of resistance as a communicative act to further suggest what might be possible for the teachers and students to transcend conflicts in order to establish a more meaningful teacher-student relationship, moving beyond zero-tolerance policies

Inhomogeneous substructures hidden in random networks

We study the structure of the load-based spanning tree (LST) that carries the maximum weight of the Erdos-Renyi (ER) random network. The weight of an edge is given by the edge-betweenness centrality, the effective number of shortest paths through the edge. We find that the LSTs present very inhomogeneous structures in contrast to the homogeneous structures of the original networks. Moreover, it turns out that the structure of the LST changes dramatically as the edge density of an ER network increases, from scale free with a cutoff, scale free, to a starlike topology. These would not be possible if the weights are randomly distributed, which implies that topology of the shortest path is correlated in spite of the homogeneous topology of the random network.Comment: 4 pages, 4 figure

Scale-free trees: the skeletons of complex networks

We investigate the properties of the spanning trees of various real-world and model networks. The spanning tree representing the communication kernel of the original network is determined by maximizing total weight of edges, whose weights are given by the edge betweenness centralities. We find that a scale-free tree and shortcuts organize a complex network. The spanning tree shows robust betweenness centrality distribution that was observed in scale-free tree models. It turns out that the shortcut distribution characterizes the properties of original network, such as the clustering coefficient and the classification of networks by the betweenness centrality distribution

THE EFFECT OF RESISTANCE AND ENDURANCE EXERCISE TRAINING ON MUSCLE PROTEOME EXPRESSION IN HUMAN SKELETAL MUSCLE

To investigate the effect of resistance and endurance training on muscle proteome expression, samples of vastus lateralis from 10 physically active young men were analysed by 2-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Differential patterns of protein expression were determined after 4 weeks of endurance or resistance exercise training. Following endurance exercise training, carbonic anhydrase III immunoglobulin heavy chain, myosin heavy chain 1, titin, chromosome 12, and fructose-1,6-bisphosphatase 2 were up-regulated while pyruvate kinase 3 isoform, ubiquitin carboxyl-terminal hydrolase, and phosphoglucomutase were down-regulated. After the 4 weeks of resistance exercise training, five proteins, apolipoprotein A-IV precursor, microtubule-actin cross linking factor 1, myosin light chain, growth hormone inducible transmembrane protein, and an unknown protein were up-regulated and pyruvate kinase 3 isoform, human albumin, and enolase 3 were down-regulated. We conclude that endurance and resistance exercise training differently alter the expression of individual muscle proteins, and that the response of muscle protein expression may be associated with specific myofibre adaptations to exercise training. Proteomic studies represent one of the developing techniques of metabolism which may substantially contribute to new insights into muscle and exercise physiology

Investing in the curricular lives of educators: narrative inquiry as pedagogical medium

This paper draws on the experiences of two graduate level curriculum theory classes taught at different teacher education institutions in the United States. As teacher educators and curriculum theorists, we invest in creating reflexive spaces for teachers to explore the complex terrain of lived curriculum. Narrative inquiry is chronicled as acting as an important pedagogical medium toward this aim. The purpose of the paper is to explore what practicing teachers’ narratives reveal about their curricular roles in relation to theory and practice. As participating educators consider their associated teaching identities, phenomenological notions of place are found to be fitting as they navigate understandings of lived curriculum as situated, thoughtful, and intentional. Insights generated through reflexive analysis manifest three thematic intersections: 1) Teachers confronting dissonance between theory and practice as teaching identity displacement; 2) Teachers negotiating greater implacement; and 3) Teachers moving toward embodying the creative space for teaching and learning. Renewed roles surface for teacher educators and curriculum theorists, challenging all involved to purposefully foster contexts for professional learning rather than subservience, and claim the responsibilities to provide the intellectual, emotional, and pragmatic spaces where teachers’ lived curriculum efforts can be developed and nurtured

Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells

In this study, we investigated the mechanistic role of the caspase cascade in extrinsic and intrinsic apoptosis induced by apigenin, which has been targeted as a candidate in the development of noncytotoxic anticancer medicines. Treatment with apigenin (1–100 µM) significantly inhibited the proliferation of MDA-MB-453 human breast cancer cells in a dose- and time-dependent manner with IC50 values of 59.44 and 35.15 µM at 24 and 72 h, respectively. This inhibition resulted in the induction of apoptosis and the release of cytochrome c in cells exposed to apigenin at its 72 h IC50. Subsequently, caspase-9, which acts in mitochondria-mediated apoptosis, was cleaved by apigenin. In addition, apigenin activated caspase-3, which functions downstream of caspase-9. The apigenin-induced activation of caspase-3 was accompanied by the cleavage of capases-6, -7, and -8. These results are supported by evidence showing that the activity patterns of caspases-3, -8, and -9 were similar. The present study supports the hypothesis that apigenin-induced apoptosis involves the activation of both the intrinsic and extrinsic apoptotic pathways