1,622 research outputs found
5,15-Bis(3,5-di-tert-butylphenyl)-10,20-bis(phenylethynyl)porphyrin
In the centrosymmetric title compound, C64H62N4, the two phenylethynyl groups lie at diagonal meso positions. The 24-membered porphyrin has in-plane distortion with respect to the mean plane of the macrocycle and two intra-ring bifurcated N—H⋯(N,N) hydrogen bonds occur. The dihedral angles between the phenyl rings in the phenylethynyl group and the 3,5-bis(tert-butyl)phenyl group with respect to the mean plane of the porphyrin are 17.2 (2) and 59.2 (3)°. The tert-butyl groups are disordered over two sets of sites in a 0.661 (13):0.339 (13) ratio
Topological Structure of Dense Hadronic Matter
We present a summary of work done on dense hadronic matter, based on the
Skyrme model, which provides a unified approach to high density, valid in the
large limit. In our picture, dense hadronic matter is described by the
{\em classical} soliton configuration with minimum energy for the given baryon
number density. By incorporating the meson fluctuations on such ground state we
obtain an effective Lagrangian for meson dynamics in a dense medium. Our
starting point has been the Skyrme model defined in terms of pions, thereafter
we have extended and improved the model by incorporating other degrees of
freedom such as dilaton, kaons and vector mesons.Comment: 13 pages, 8 figures, Talk given at the KIAS-APCTP Symposium in
Astro-Hadron Physics "Compact Stars: Quest for New States of Dense Matter",
November 10-14, 2003, Seoul, Korea, published by World Scientific. Based on
talk by B.-Y. Par
Two-Dimensional Dirac Fermions Protected by Space-Time Inversion Symmetry in Black Phosphorus
We report the realization of novel symmetry-protected Dirac fermions in a
surface-doped two-dimensional (2D) semiconductor, black phosphorus. The widely
tunable band gap of black phosphorus by the surface Stark effect is employed to
achieve a surprisingly large band inversion up to ~0.6 eV. High-resolution
angle-resolved photoemission spectra directly reveal the pair creation of Dirac
points and their moving along the axis of the glide-mirror symmetry. Unlike
graphene, the Dirac point of black phosphorus is stable, as protected by
spacetime inversion symmetry, even in the presence of spin-orbit coupling. Our
results establish black phosphorus in the inverted regime as a simple model
system of 2D symmetry-protected (topological) Dirac semimetals, offering an
unprecedented opportunity for the discovery of 2D Weyl semimetals
Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease
Chung-pae (CP) inhalation therapy is a method frequently used in Korea to treat lung disease, especially chronic obstructive pulmonary disease (COPD). This study investigated the effects of CP inhalation on a COPD animal model. C57BL/6 mice received porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS) alternately three times for 3 weeks to induce COPD. Then, CP (5 or 20 mg/kg) was administered every 2 h after the final LPS administration. The effect of CP was evaluated by bronchoalveolar lavage (BAL) fluid analysis, histological analysis of lung tissue, and reverse transcription polymerase chain reaction analysis of mRNA of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) α, IL-6, and tumor growth factor- (TGF-) β. Intratracheal CP administration reduced the number of leukocytes and neutrophils in BAL fluid, inhibited the histological appearance of lung damage, and decreased the mRNA levels of the proinflammatory cytokines IL-1β, TNF-α, IL-6, and TGF-β. Intratracheal CP administration effectively decreased the chronic inflammation and pathological changes in a PPE- and LPS-induced COPD mouse model. Therefore, we suggest that CP is a promising strategy for COPD
Disentangled representation learning for multilingual speaker recognition
The goal of this paper is to learn robust speaker representation for
bilingual speaking scenario. The majority of the world's population speak at
least two languages; however, most speaker recognition systems fail to
recognise the same speaker when speaking in different languages.
Popular speaker recognition evaluation sets do not consider the bilingual
scenario, making it difficult to analyse the effect of bilingual speakers on
speaker recognition performance. In this paper, we publish a large-scale
evaluation set named VoxCeleb1-B derived from VoxCeleb that considers bilingual
scenarios.
We introduce an effective disentanglement learning strategy that combines
adversarial and metric learning-based methods. This approach addresses the
bilingual situation by disentangling language-related information from speaker
representation while ensuring stable speaker representation learning. Our
language-disentangled learning method only uses language pseudo-labels without
manual information.Comment: Interspeech 202
Real-time detection of an airborne microorganism using inertial impaction and mini-fluorescent microscopy
To achieve successful real-time detection of airborne pathogenic microorganisms, the problem must be considered in terms of their physical size and biological characteristics. We developed an airborne microorganism detection chip to realize the detection of microorganisms, ensuring compactness, sensitivity, cost-efficiency, and portability, using three key components: an inertial impaction system, a cartridge-type impaction plate, and a mini-fluorescent microscope. The inertial impaction system was used to separate microorganisms in terms of their aerodynamic particle size, and was fabricated with three impaction stages. Numerical analysis was performed to design the system; the calculated cutoff diameter at each impaction stage was 2.02 (first stage), 0.88 (second stage), and 0.54 μm (third stage). The measured cutoff diameters were 2.24, 0.91, and 0.49 μm, respectively. A cartridge-type impaction plate was used, composed of molded polydimethylsiloxane (PDMS) and an actual impaction region made of a SYBR green I dye-stained agar plate. A mini-fluorescent microscope was used to distinguish microbes from non-biological particles. Images of the microorganisms deposited at the impaction zone were obtained via mini-fluorescent microscopy, and fluorescent intensities of the images were calculated using in-house image-processing software. The results showed that the developed system successfully identified aerosolized biological particles from non-biological particles in real time
ArrayXPath II: mapping and visualizing microarray gene-expression data with biomedical ontologies and integrated biological pathway resources using Scalable Vector Graphics
Summary: ArrayXPath () is a web-based service for mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics (SVG). Deciphering the crosstalk among pathways and integrating biomedical ontologies and knowledge bases may help biological interpretation of microarray data. ArrayXPath is empowered by integrating gene-pathway, disease-pathway, drug-pathway and pathway–pathway correlations with integrated Gene Ontology, Medical Subject Headings and OMIM Morbid Map-based annotations. We applied Fisher's exact test and relative risk to evaluate the statistical significance of the correlations. ArrayXPath produces Javascript-enabled SVGs for web-enabled interactive visualization of gene-expression profiles integrated with gene-pathway-disease interactions enriched by biomedical ontologies
The impact of sequential versus single anastomoses on flow characteristics and mid-term patency of saphenous vein grafts in coronary bypass grafting
ObjectiveTo assess the influence of bypass grafting technique on the flow characteristics and mid-term patency of saphenous vein coronary bypass grafts.MethodsIn the present study, 309 patients who underwent either sequential (group A, N = 84 grafts) or individual (group B, N = 244 grafts) saphenous vein coronary bypass grafting between February 2002 and September 2007 were investigated. Individual bypassing only was performed in 212 patients, and sequential bypassing only was performed in 78 patients. The remaining 19 patients received both. A total of 436 distal anastomoses were performed with 328 saphenous vein grafts. The intraoperative flow characteristics and the graft patency were assessed with the transit time flow meter and serial multi-detector computed tomography coronary angiograms, respectively.ResultsGroup A showed a higher mean flow compared with group B at 49.4 ± 27.4 mL/min versus 37.1 ± 20.1 mL/min, respectively (P = .001). The mean flow increased linearly as the number of anastomoses increased per graft (P < .001). Graft patency at 3 years was 93.3% ± 3.4% in group A and 86.5% ± 3.1% in group B (P = .048). After adjustment for baseline characteristics, group A showed a tendency for superior mid-term patency than group B (hazard ratio 0.362; 95% confidence interval, 0.129–1.017; P = .0538).ConclusionsSequential bypass grafts were associated with higher mean flows and superior mid-term patency compared with individual grafts. These findings suggest the more favorable results of sequential bypass grafting to be attributed to the enhanced flow hemodynamics
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