Odontoameloblastoma with extensive chondroid matrix deposition in a guinea pig

Odontoameloblastomas (previously incorporated within ameloblastic odontomas) are matrix-producing odontogenic mixed tumors and are closely related in histologic appearance to the 2 other types of matrix-producing odontogenic mixed tumors: odontomas and ameloblastic fibro-odontomas. The presence or absence of intralesional, induced non-neoplastic tissue must be accounted for in the diagnosis. Herein we describe a naturally occurring odontoameloblastoma with extensive chondroid cementum deposition in a guinea pig (Cavia porcellus). Microscopically, the mass featured palisading neoplastic odontogenic epithelium closely apposed to ribbons and rings of a pink dental matrix (dentinoid), alongside extensive sheets and aggregates of chondroid cementum. The final diagnosis was an odontoameloblastoma given the abundance of odontogenic epithelium in association with dentinoid but a paucity of pulp ectomesenchyme. Chondroid cementum is an expected anatomical feature of cavies, and its presence within the odontoameloblastoma was interpreted as a response of the ectomesenchyme of the dental follicle to the described neoplasm. Our case illustrates the inductive capabilities of odontoameloblastomas while highlighting species-specific anatomy that has resulted in a histologic appearance unique to cavies and provides imaging and histologic data to aid diagnosis of these challenging lesions

Getting Grounded in the Post Hometown World

Remember when Americans had hometowns? Where are you from? we\u27d ask one another. And the answer would come back: New York City. St. Joseph, Mo. Atlanta. Santa Barbara, Calif. Chattanooga, Tenn. But odds are that now we\u27d get a more complicated response. It\u27d go something like this: Well, I was born in Atlanta but we moved to Baltimore when I was 11 and in my junior year of high school, we went out to L.A. I\u27ve been in Chicago for a year. And even this might not be quite accurate. The speaker may have been born in an Atlanta exurb and have moved with her parents to a Baltimore suburb and subsequently to a town some miles outside Los Angeles before migrating to a community close to but not in Chicago. So where should one consider her from? All over, maybe? Which raises the question: does this erosion of a sense of place matter? Yes, it does. For throughout history, people have derived their identity in part from where they lived. Now, every year an estimated 45 million Americans move

Will Another White Male Be Elected President in 2008?

Barack Obama. Hillary Rodham Clinton. Bill Richardson. The field of minority and female candidates for president has never been so strong. But the question remains: Despite the expected presence of an African- American, a woman, and a Latino, will America in 2008 elect yet another male president of northern European descent? No one can say for certain, but we hope this streak ends soon, because it\u27s important that America elect its leaders from the full breadth of talent available in its diverse population

Too Many Options Dilute Shared Experience

Despite the red carpet glitter of the Oscars, it is no secret that Hollywood has had a far from perfect year at the box office. And unfortunately for Tinsel Town, its problems go beyond the obvious need for more successful films. The way we experience both movies and television has evolved. We don\u27t do things together the way we once did. We rent movies and watch them at home rather than going to a local movie theater with family and friends. Box office returns suffer and the centrality of film in our lives is weakened. The same fragmentation is true in television. Sadly, the kind of cultural reference points provided by the likes of Johnny Carson, Lucille Ball, Jackie Gleason, and more - including the superstar network news anchors in their prime - are fading. They provided a snug sense of intimacy that comes from a shared common experience. The result? Significant social change brought on by audience fragmentation. The root cause? A proliferation of entertainment options impelled by niche-driven marketing

Exploring a Cognitive Basis for Learning Spatial Relationships with Augmented Reality

Augmented reality (AR) is an emergent class of interface that presents compelling possibilities for advancing spatial visualization. We offer a brief overview of AR technology and current research with in the educational realm. AR interfaces appear to provide a unique combination of visual display properties, modes of user manipulation, and interaction with spatial information. Drawing upon aspects of proprioception and sensorimotor function, we discuss how AR may have a unique and powerful link to spatial knowledge acquisition through visuo-motor involvement in the processing of information. We identify key properties of AR interfaces and how they differ from conventional visualization interfaces, followed by a discussion of theoretical perspectives that make a case for learning spatial relationships using first person manipulative AR.Recent research provides evidence that this form of AR holds cognitive advantages for learning when compared with traditional desktop 2D interfaces. We review the visual-physical connections to learning using first person manipulative AR within educational contexts. We then provide some suggestions for building future research in this area and explore its significance in the realm of spatial knowledge acquisition

‘Pontinization’ of the medulla: two clinical case studies

The authors report 2 clinical cases of human brainstems where there is blurring of the boundary between the medulla and pons, leading to "pontinization" of the medull

Synergy of debris mitigation and removal

At the beginning of the twenty-first century there was considerable effort made using evolutionary models to assess the effectiveness of post-mission disposal (PMD) and other mitigation measures to stabilise the growth of the debris population in low Earth orbit (LEO). Subsequently, this activity led to the recommendation of a “25-year rule” for the post-mission disposal of spacecraft and orbital stages intersecting the LEO region. At the time, it was anticipated that the 25-year rule, together with passivation and suppression of mission-related debris, would be sufficient to prevent the continued growth of the LEO debris population. However, in the last decade both the LEO debris environment and the debris modelling capability have seen significant changes. In particular, recent population growth has been driven by a number of major break-ups, including the intentional destruction of the Fengyun-1C spacecraft and the collision between Iridium 33 and Cosmos 2251. State-of-the-art evolutionary models now indicate that mitigation measures alone are insufficient to stabilise the LEO debris population. Consequently, this has led to considerable interest in the remediation of the debris environment and, especially, in debris removal. Yet there is a reluctance to revisit the role of PMD within the wider goal of remediation even though it does not provide the solution that was expected. Thus, there is a risk that the approach to remediation will follow a sequential, “over-the-fence” philosophy, which tends to deliver costly, and less than optimal solutions. In this paper, we present a new and large study of debris mitigation and removal using the University of Southampton’s evolutionary model, DAMAGE, together with the latest MASTER model population of objects > 10 cm in LEO. Here, we have employed a concurrent approach to remediation, whereby changes to the PMD rule and the inclusion of other mitigation measures have been considered alongside multiple removal strategies. In this way, we have been able to demonstrate the synergy of these measures and to identify aggregate solutions to the space debris problem. The results suggest that reducing the PMD decay rule offers benefits that include an increase in the effectiveness of debris removal and a corresponding increase in the confidence that these combined measures will lead to the stabilisation of the LEO debris population

An evaluation of genotyping by sequencing (GBS) to map the <em>Breviaristatum-e (ari-e)</em> locus in cultivated barley

ABSTRACT: We explored the use of genotyping by sequencing (GBS) on a recombinant inbred line population (GPMx) derived from a cross between the two-rowed barley cultivar ‘Golden Promise’ (ari-e.GP/Vrs1) and the six-rowed cultivar ‘Morex’ (Ari-e/vrs1) to map plant height. We identified three Quantitative Trait Loci (QTL), the first in a region encompassing the spike architecture gene Vrs1 on chromosome 2H, the second in an uncharacterised centromeric region on chromosome 3H, and the third in a region of chromosome 5H coinciding with the previously described dwarfing gene Breviaristatum-e (Ari-e). BACKGROUND: Barley cultivars in North-western Europe largely contain either of two dwarfing genes; Denso on chromosome 3H, a presumed ortholog of the rice green revolution gene OsSd1, or Breviaristatum-e (ari-e) on chromosome 5H. A recessive mutant allele of the latter gene, ari-e.GP, was introduced into cultivation via the cv. ‘Golden Promise’ that was a favourite of the Scottish malt whisky industry for many years and is still used in agriculture today. RESULTS: Using GBS mapping data and phenotypic measurements we show that ari-e.GP maps to a small genetic interval on chromosome 5H and that alternative alleles at a region encompassing Vrs1 on 2H along with a region on chromosome 3H also influence plant height. The location of Ari-e is supported by analysis of near-isogenic lines containing different ari-e alleles. We explored use of the GBS to populate the region with sequence contigs from the recently released physically and genetically integrated barley genome sequence assembly as a step towards Ari-e gene identification. CONCLUSIONS: GBS was an effective and relatively low-cost approach to rapidly construct a genetic map of the GPMx population that was suitable for genetic analysis of row type and height traits, allowing us to precisely position ari-e.GP on chromosome 5H. Mapping resolution was lower than we anticipated. We found the GBS data more complex to analyse than other data types but it did directly provide linked SNP markers for subsequent higher resolution genetic analysis