5,340 research outputs found
Penetration of fusidic acid and rifampicin into cerebrospinal fluid in low-grade inflammatory meningitis caused by Staphylococcus epidermidis
AbstractCerebrospinal fluid (CSF) concentration-time curves of rifampicin and fusidic acid were studied in a patient with post-operative meningitis caused by Staphylococcus epidermidis. The patient was treated with this combination of antimicrobial agents because of a severe hypersensitivity reaction to vancomycin. Peak CSF concentrations of rifampicin exceeded the MIC by > 60-fold, while those of fusidic acid just reached the MIC. CSF concentrations of fusidic acid were relatively stable within the range reported for patients with uninflamed meninges, but serum levels were surprisingly low. An increase in the metabolism of fusidic acid induced by rifampicin cannot be excluded
Project status of the CMS tracker optical links
The development phase of the optical data transfer system for the CMS tracker is now complete. This paper presents the project status and reviews the preparation for production. In particular, it focuses on the results of the market surveys for front-end components, and on the performance evaluation of a close-to-final readout chain. I
A review of clinical decision-making: Models and current research
Aims and objectives: The aim of this paper was to review the current literature with respect to clinical decision-making models and the educational application of models to clinical practice. This was achieved by exploring the function and related research of the three available models of clinical decision making: information processing model, the intuitive-humanist model and the clinical decision making model.
Background: Clinical decision-making is a unique process that involves the interplay between knowledge of pre-existing pathological conditions, explicit patient information, nursing care and experiential learning. Historically, two models of clinical decision making are recognised from the literature; the information processing model and the intuitive-humanist model. The usefulness and application of both models has been examined in relation the provision of nursing care and care related outcomes. More recently a third model of clinical decision making has been proposed. This new multidimensional model contains elements of the information processing model but also examines patient specific elements that are necessary for cue and pattern recognition.
Design: Literature review
Methods: Evaluation of the literature generated from MEDLINE, CINAHL, OVID, PUBMED and EBESCO systems and the Internet from 1980 – November 2005
Vibrational Study of 13C-enriched C60 Crystals
The infrared (IR) spectrum of solid C60 exhibits many weak vibrational modes.
Symmetry breaking due to 13C isotopes provides a possible route for optically
activating IR-silent vibrational modes. Experimental spectra and a
semi-empirical theory on natural abundance and 13C-enriched single crystals of
C60 are presented. By comparing the experimental results with the theoretical
results, we exclude this isotopic activation mechanism from the explanation for
weakly active fundamentals in the spectra.Comment: Accepted for Phys. Rev. B, typeset in REVTEX v3.0 in LaTeX.
Postscript file including figures is available at
http://insti.physics.sunysb.edu/~mmartin/papers/c13twocol2.ps File with
figures will be e-mailed by reques
The liminality of trajectory shifts in institutional entrepreneurship
In this paper, we develop a process model of trajectory shifts in institutional entrepreneurship. We focus on the liminal periods experienced by institutional entrepreneurs when they, unlike the rest of the organization, recognize limits in the present and seek to shift a familiar past into an unfamiliar and uncertain future. Such periods involve a situation where the new possible future, not yet fully formed, exists side-by-side with established innovation trajectories. Trajectory shifts are moments of truth for institutional entrepreneurs, but little is known about the underlying mechanisms of how entrepreneurs reflectively deal with liminality to conceive and bring forth new innovation trajectories. Our in-depth case study research at CarCorp traces three such mechanisms (reflective dissension, imaginative projection, and eliminatory exploration) and builds the basis for understanding the liminality of trajectory shifts. The paper offers theoretical implications for the institutional entrepreneurship literature
Step-Wise Computational Synthesis of Fullerene C60 derivatives. 1.Fluorinated Fullerenes C60F2k
The reactions of fullerene C60 with atomic fluorine have been studied by
unrestricted broken spin-symmetry Hartree-Fock (UBS HF) approach implemented in
semiempirical codes based on AM1 technique. The calculations were focused on a
sequential addition of fluorine atom to the fullerene cage following indication
of the cage atom highest chemical susceptibility that is calculated at each
step. The effectively-non-paired-electron concept of the fullerene atoms
chemical susceptibility lays the foundation of the suggested computational
synthesis. The obtained results are analyzed from energetic, symmetry, and the
composition abundance viewpoints. A good fitting of the data to experimental
findings proves a creative role of the suggested synthesis methodology.Comment: 33 pages, 11 figures, 2 tables, 2 chart
Riesz potentials and nonlinear parabolic equations
The spatial gradient of solutions to nonlinear degenerate parabolic equations
can be pointwise estimated by the caloric Riesz potential of the right hand
side datum, exactly as in the case of the heat equation. Heat kernels type
estimates persist in the nonlinear cas
Hadron beam test of a scintillating fibre tracker system for elastic scattering and luminosity measurement in ATLAS
A scintillating fibre tracker is proposed to measure elastic proton
scattering at very small angles in the ATLAS experiment at CERN. The tracker
will be located in so-called Roman Pot units at a distance of 240 m on each
side of the ATLAS interaction point. An initial validation of the design
choices was achieved in a beam test at DESY in a relatively low energy electron
beam and using slow off-the-shelf electronics. Here we report on the results
from a second beam test experiment carried out at CERN, where new detector
prototypes were tested in a high energy hadron beam, using the first version of
the custom designed front-end electronics. The results show an adequate
tracking performance under conditions which are similar to the situation at the
LHC. In addition, the alignment method using so-called overlap detectors was
studied and shown to have the expected precision.Comment: 12 pages, 8 figures. Submitted to Journal of Instrumentation (JINST
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Shared picture book reading interventions for child language development: a systematic review and meta-analysis
Interventions that train parents to share picture books with children are seen as a strategy for supporting child language development. We conducted meta‐analyses using robust variance estimation modeling on results from 19 RCTs (Ntotal = 2,594; Mchildage = 1–6 years). Overall, book‐sharing interventions had a small sized effect on both expressive language (d = 0.41) and receptive language (d = 0.26). They had a large effect on caregiver book‐sharing competence (d = 1.01). The impact of the intervention on child language was moderated by intervention dosage, with lower dosage associated with a minimal impact. Child age and caregiver education level were unrelated to child outcome. This review and meta‐analysis confirms the promise of book‐sharing interventions for enhancing and accelerating child language development
Continuous symmetry of C60 fullerene and its derivatives
Conventionally, the Ih symmetry of fullerene C60 is accepted which is
supported by numerous calculations. However, this conclusion results from the
consideration of the molecule electron system, of its odd electrons in
particular, in a close-shell approximation without taking the electron spin
into account. Passing to the open-shell approximation has lead to both the
energy and the symmetry lowering up to Ci. Seemingly contradicting to a
high-symmetry pattern of experimental recording, particularly concerning the
molecule electronic spectra, the finding is considered in the current paper
from the continuous symmetry viewpoint. Exploiting both continuous symmetry
measure and continuous symmetry content, was shown that formal Ci symmetry of
the molecule is by 99.99% Ih. A similar continuous symmetry analysis of the
fullerene monoderivatives gives a reasonable explanation of a large variety of
their optical spectra patterns within the framework of the same C1 formal
symmetry exhibiting a strong stability of the C60 skeleton.Comment: 11 pages. 5 figures. 6 table
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