1,850 research outputs found
Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial
In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment. Fifty patients with idiopathic dysgeusia were carefully selected. Zinc gluconate (140 mg/day; n = 26) or placebo (lactose; n = 24) was randomly assigned to the patients. The patients on zinc improved in terms of gustatory function (p < 0.001) and rated the dysgeusia as being less severe (p < 0.05). Similarly, signs of depression in the zinc group were less severe (Beck Depression Inventory, p < 0.05; mood scale, p < 0.05). With the exception of the salivary calcium level, which was higher in the zinc patients (p < 0.05), no other significant group differences were found. In conclusion, zinc appears to improve general gustatory function and, consequently, general mood scores in dysgeusia patients
Transport Properties of Strong-Interaction Matter
The properties of strong-interaction matter are probed in ultra-relativistic
heavy-ion collisions. In the context of measurements of the elliptic flow at
RHIC and the LHC the shear viscosity is of particular interest. In this
presentation we discuss recent results for eta/s in hadronic matter at
vanishing baryo-chemical potential within kinetic theory. Using the
Nambu-Jona-Lasinio model, special attention is paid to effects arising from the
restoration of spontaneously broken chiral symmetry with increasing
temperature.Comment: 8 pages, 4 figures, presented at the HIC for FAIR Workshop and XXVIII
Max Born Symposium "Three days on Quarkyonic Island", Wroclaw, May 19-21,
2011; v2: conversion to Pa in fig. 2 correcte
On the Significance of the Weyl Curvature in a Relativistic Cosmological Model
The Weyl curvature includes the Newtonian field and an additional field, the
so-called anti-Newtonian. In this paper, we use the Bianchi and Ricci
identities to provide a set of constraints and propagations for the Weyl
fields. The temporal evolutions of propagations manifest explicit solutions of
gravitational waves. We see that models with purely Newtonian field are
inconsistent with relativistic models and obstruct sounding solutions.
Therefore, both fields are necessary for the nonlocal nature and radiative
solutions of gravitation.Comment: 15 pages, incorporating proof correction
Recommended from our members
Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes.
BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain. The combination of the two leads to the formation of a structural systems biology framework, which we have used to analyze differences between the reactive oxygen species (ROS) sensitivity of the proteomes of sequenced strains of E. coli. As proteins are one of the main targets of oxidative damage, understanding how the genetic changes of different strains of a species relates to its oxidative environment can reveal hypotheses as to why these variations arise and suggest directions of future experimental work. RESULTS:Creating a reference structural proteome for E. coli allows us to comprehensively map genetic changes in 1764 different strains to their locations on 4118 3D protein structures. We use metabolic modeling to predict basal ROS production levels (ROStype) for 695 of these strains, finding that strains with both higher and lower basal levels tend to enrich their proteomes with antioxidative properties, and speculate as to why that is. We computationally assess a strain's sensitivity to an oxidative environment, based on known chemical mechanisms of oxidative damage to protein groups, defined by their localization and functionality. Two general groups - metalloproteins and periplasmic proteins - show enrichment of their antioxidative properties between the 695 strains with a predicted ROStype as well as 116 strains with an assigned pathotype. Specifically, proteins that a) utilize a molybdenum ion as a cofactor and b) are involved in the biogenesis of fimbriae show intriguing protective properties to resist oxidative damage. Overall, these findings indicate that a strain's sensitivity to oxidative damage can be elucidated from the structural proteome, though future experimental work is needed to validate our model assumptions and findings. CONCLUSION:We thus demonstrate that structural systems biology enables a proteome-wide, computational assessment of changes to atomic-level physicochemical properties and of oxidative damage mechanisms for multiple strains in a species. This integrative approach opens new avenues to study adaptation to a particular environment based on physiological properties predicted from sequence alone
Enantio-Complementary Continuous-Flow Synthesis of 2-Aminobutane Using Covalently Immobilized Transaminases
Chiral amines are a common feature of many active
pharmaceutical ingredients. The synthesis of very small chiral
amines is particularly challenging, even via biocatalytic routes, as the
level of discrimination between similarly sized R-groups must be
exceptional, yet their synthesis creates attractive building blocks that
may then be used to prepare diverse compounds in further steps.
Herein, the synthesis of one of the smallest chiral amines, 2-
aminobutane, using transaminases, is being investigated. After
screening a panel of mainly wild-type transaminases, two candidates
were identified: an (S)-selective transaminase from Halomonas
elongata (HEwT) and a precommercial (R)-selective transaminase
from Johnson Matthey (*RTA-X43). Notably, a single strategic
point mutation enhanced the enantioselectivity of HEwT from 45
to >99.5% ee. By covalently immobilizing these candidates, both enantiomers of 2-aminobutane were synthesized on a multigram scale, and the feasibility of isolation by distillation without the need for any solvents other than water was demonstrated. The atom economy of the process was calculated to be 56% and the E-factors (including waste generated during enzyme expression and immobilization) were 55 and 48 for the synthesis of (R)-2-aminobutane and (S)-2-aminobutane, respectively
Can noncommutativity resolve the Big-Bang singularity?
A possible way to resolve the singularities of general relativity is proposed
based on the assumption that the description of space-time using commuting
coordinates is not valid above a certain fundamental scale. Beyond that scale
it is assumed that the space-time has noncommutative structure leading in turn
to a resolution of the singularity. As a first attempt towards realizing the
above programme a modification of the Kasner metric is constructed which is
commutative only at large time scales. At small time scales, near the
singularity, the commutation relations among the space coordinates diverge. We
interpret this result as meaning that the singularity has been completely
delocalized.Comment: Latex, 13 pages, 2 figures, accepted for publication in EPJ
Tachyonic potential in Bianchi type-I universe
Motivated from recent string theoretic results, a tachyonic potential is
constructed for a spatially homogeneous and anisotropic background cosmology.Comment: 5 pages,LATEX,Typos in the text corrected, more references adde
Incidence of seropositive myasthenia gravis in Cape Town and South Africa
Background. Myasthenia gravis (MG) is a treatable autoimmune disease characterised by fatiguable weakness of skeletal muscles. More than 85% of MG patients have antibodies to the acetylcholine receptor (AChR) at the neuromuscular junction or are seropositive for MG (SPMG). In the developed world the incidence of MG has increased, particularly among older individuals, but no epidemiological studies have been done on SPMG in Africa.
Objectives. To determine the annual incidence rate (IR) of SPMG in the Cape Town (CT) municipality, and the crude annual IR of SPMG for the whole of South Africa (SA).
Methods. Positive AChR antibody tests were identified between 1 January 2003 and 1 January 2005 for patients living in CT, and the age- and sex-specific incidences were calculated. To determine the national crude annual IR over the same period, positive assays were identified from the laboratories that process AChR assays for SA. National Census 2001 population statistics formed the denominators.
Results. There were 65 positive assays in CT, and 230 nationwide. Based on these figures the annual IR for CT was 11.2 per million per year (95% confidence interval (CI) 8.7 - 14.3), and for South Africa 2.6 per million / year (95% CI 2.2 - 2.9). After a questionnaire response from CT neurologists regarding the routine use of the AChR antibody assay, the annual IR for CT was adjusted to 12.6 per million (95% CI 9.9 - 15.9) to incorporate those presumed to have SPMG without a confirmatory test. In CT, the IR in females was 15.3 per million / year (95% CI 11.2 - 20.4), and in males, 6.8 per million / year (95% CI 4.1 - 10.7). The CT IRs for blacks, coloureds and whites were not statistically different after adjusting for age and gender. The IR of SPMG in CT was 6 times greater in those presenting after the age of 50 years than in those with earlier disease onset (95% CI 3.7 - 9.7).
Conclusions. The annual IR of SPMG in CT is much the same as rates recorded recently in other developed countries, but the rest of SA has a much lower IR. A preponderance of MG starting after the age of 50 years reflects a worldwide trend, although the CT data showed a relatively lower-than-expected incidence for older males. IRs for SPMG vary widely in different regions in SA; this is likely to be related to differences in regional health care delivery, and underdiagnosis
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