Research on optimal environmental tax, sub-optimal selection and influencing factors in China

Considering the definition of the optimal environment tax, according to the sub-optimal choice under real conditions, Marginal cost of emission reduction is regarded as environmental tax payable and listed as a dependent variable. Through setting the independent variables, selecting samples and making empirical analysis, the conclusions of the paper are as follows: The actual environmental tax charged is positively correlated with government supervision and public participation, and negatively correlated with enterprise environmental investment, government environmental expenditure, upgrading of industrial structure and size of enterprise. At last, the paper puts forward some suggestions: strictly enforce the environmental tax, encourage public participation and increase the investment on environmental protection

Research on flow characteristics of aerostatic circular thrust bearing

In order to improve the pressure distribution, the aerostatic circular thrust bearing with single supply hole was studied. In the computational fluid dynamics (CFD) simulation, the laminar model, the turbulent model, the mixture model of laminar and turbulent were used simultaneously. The micro-characteristics of the gas flows were analysed based on the simulation results. One test rig was built for measuring the pressure distribution with the single test hole, and the calculated and experimental results were compared. The results showed that when the gas film clearance is small and the gas flow is subsonic completely, the whole gas flow is laminar flow, which should be calculated based on the laminar model and when the gas film thickness is large and there is supersonic flow in some region, which should be calculated according to the mixture model; at the same time, there is no surface of discontinuity for Mach number and pressure distribution, and no shock, and the pressure is recovered due to the boundary layer separation, the change of the flow state and the change of viscosity. The method for testing the pressure distributions with a single test hole is effective

Rotation Accuracy Analysis of Aerostatic Spindle Considering Shaft’s Roundness and Cylindricity

The rotation accuracy of the aerostatic spindle can easily be affected by shaft shape errors due to the small gas film clearance. Thus, the main shaft shape errors with the largest scale—that is, the roundness and cylindricity errors—are studied in this paper, and a dynamic mathematical model is established with the consideration of the roundness, cylindricity errors, and spindle speed. In order to construct the shaft model, the discrete coefficient index of the shaft radius based on roundness measurement data are proposed. Then, the simulation calculations are conducted based on the measured cylindricity data and the constructed shaft model. The calculation results are compared with the spindle rotation accuracy measured using the spindle error analyzer. The results show that the shaft with a low discrete coefficient is subjected to less unbalanced force and smaller rotation errors, as obtained by the experiment

Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions

Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can be classified into animal- and plant-derived ω-3 PUFAs. Patients with type 2 diabetes (T2DM) are frequently accompanied by dyslipidemia, which is closely related to the high-density lipoprotein (HDL-C) subfractions change. This study aimed to determine the effects of different sources ω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with dyslipidemia. Ninety T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fish oil (FO, containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), 3 g/day perilla oil (PO, containing α-linolenic acid (ALA)), or 3 g/day blend oil (BO, containing EPA, DHA and ALA) for 3 months. 90 patients completed the intervention. There was a significant reduction of glycated hemoglobin (HbA1c) in all the groups. The triglycerides (TG) in the FO group were significantly different with a group × time interaction (P = 0.043), which was higher compared with the other two groups. The serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO groups. Plant-derived ω-3 PUFAs are more effective at controlling blood glucose than animal-derived ω-3 PUFAs. However, animal-derived ω-3 PUFAs have a significant lowering effect on TG compared with plant-derived ω-3 PUFAs. Particularly, large HDL-C subfractions after animal-derived ω-3 PUFAs intake were higher than plant-derived ω-3 PUFAs intake; while small HDL-C subfractions were lower. Both the animal- and plant-derived ω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia

Surface Reconstruction of CsPbBr₃ Nanocrystals by the Ligand Engineering Approach for Achieving High Quantum Yield and Improved Stability

Oleylamine/oleic acid (OAm/OA) as the commonly used ligand is indispensable in the synthesis of perovskite nanocrystals (PNCs). Unfortunately, poor colloidal stability and unsatisfactory photoluminescence quantum yield (PLQY) are observed, resulting from a highly dynamic binding nature between ligands. Herein, we adopt a facile hybrid ligand (DDAB/ZnBr2) passivation strategy to reconstruct the surface chemistry of CsPbBr3 NCs. The hybrid ligand can detach the native surface ligand, in which the acid–base reactions between ligands are suppressed effectively. Also, they can substitute the loose capping ligand, anchor to the surface firmly, and supply sufficient halogens to passivate the surface trap, realizing an exceptional PLQY of 95% and an enhanced tolerance toward ambient storage, UV irradiation, anti-solvents, and thermal treatment. Besides, the as-fabricated white light-emitting diode (WLED) utilizing the PNCs as the green-emitting phosphor has a luminous efficiency around 73 lm/W; the color gamut covers 125% of the NTSC standard

RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma

Abstract Background As a small G protein of Ras family, Ras-like-without-CAAX-1 (RIT1) plays a critical role in various tumors. Our previous study has demonstrated the involvement of RIT1 in promoting malignant progression of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. Methods Gene set enrichment analysis (GSEA) was conducted in the TCGA LIHC cohort to investigate the underlying biological mechanism of RIT1. Live cell imaging, immunofluorescence (IF) and flow cytometry assays were used to verify biological function of RIT1 in HCC mitosis. Subcutaneous xenografting of human HCC cells in BALB/c nude mice was utilized to assess tumor proliferation in vivo. RNA-seq, co-immunoprecipitation (Co-IP), mass spectrometry analyses, western blot and IF assays were employed to elucidate the mechanisms by which RIT1 regulates mitosis and promotes proliferation in HCC. Results Our findings demonstrate that RIT1 plays a crucial role in regulating mitosis in HCC. Knockdown of RIT1 disrupts cell division, leading to G2/M phase arrest, mitotic catastrophe, and apoptosis in HCC cells. SMC3 is found to interact with RIT1 and knockdown of SMC3 attenuates the proliferative effects mediated by RIT1 both in vitro and in vivo. Mechanistically, RIT1 protects and maintains SMC3 acetylation by binding to SMC3 and PDS5 during mitosis, thereby promoting rapid cell division and proliferation in HCC. Notably, we have observed an upregulation of SMC3 expression in HCC tissues, which is associated with poor patient survival and promotion of HCC cell proliferation. Furthermore, there is a significant positive correlation between the expression levels of RIT1, SMC3, and PDS5. Importantly, HCC patients with high expression of both RIT1 and SMC3 exhibit worse prognosis compared to those with high RIT1 but low SMC3 expression. Conclusions Our findings underscore the crucial role of RIT1 in regulating mitosis in HCC and further demonstrate its potential as a promising therapeutic target for HCC treatment