Prevalence of hyperglycemia in masters athletes

BACKGROUND: Ageing is associated with decreased physical activity, obesity and subsequently an increased risk of developing type 2 diabetes mellitus (T2dm). Master athletes (MA) have initiated exercise or sport later in life or pursued a physically active lifestyle for an extended period. Subsequently, MAs have been proposed as a model of successful ageing as this active lifestyle is associated with health benefits including decreased health risk of chronic diseases and a reduction in premature mortality. Given long-term physical activity/exercise has previously been shown to be protective against hyperglycemia, a risk factor for T2dm, it is plausible that MA may have protective benefit against developing hyperglycemia. Therefore, the aim of this study was to investigate the prevalence of hyperglycemia via fasting plasma glucose (FPG) in MAs competing at the World Masters Games (WMG). METHODS: This cross-sectional, observational survey utilized an online survey using open-source web-based software was used to investigate MAs physiological and medical-related parameters. Over 28,000 MAs competed in the WMG, of which 8,072 MAs completed the survey. Of these MAs, a total of 486 (males 277, females 209; range 27 to 91 years, mean age 55.1 ± 10.2 years) attained recent pathology results which included FPG which was subsequently analyzed for this study. FPG and other outcome variables were compared between genders and to the Australian and United States general population. RESULTS: Mean FPG for MAs was 5.03 mmol (±1.2, 95% CI [4.9-5.1] mmol) with majority (75.5%) of MAs reporting a normal (5.51 to 7.0 mmol). There was no significant difference ( = 0.333) in FPG between genders however, males had a slightly higher (+2.1%) FPG as compared to females (5.08 ± 1.2 mmol (95% CI [4.9-5.22] mmol) versus 4.98 ± 1.1 mmol (95% CI 4.8-5.1 mmol)). The majority of males (71.8%) and females (80.3%) were classified with a normal FPG. With regard to an abnormal FPG level, only 4.0% of males and 4.9% of females were classified abnormal which was suggestive of undiagnosed T2dm. With regard to age by decade, there was no significant difference ( = 0.06-1.00) between age groups and no relationship between the MAs\u27 age and FPG ( = .054, = 0.24). As a group, MAs had a significantly lower FPG as compared to the Australian (-3.2%, = 0.005) and United States general populations (-13.9%, \u3c 0.001). CONCLUSIONS: Most, however not all, MAs were found to have normal glycaemia, with only a small percentage indicating a risk of developing T2dm (i.e., impaired fasting glucose) and a smaller percentage identified with an abnormal FPG, suggestive of T2dm. These findings suggest MAs appear to be at low metabolic risk for developing T2dm based upon FPG and the physical activity/exercise they complete as MAs may indeed be protective against hyperglycemia whilst maintaining an active lifestyle

Resting Blood Pressure in Master Athletes: Immune from Hypertension?

Ageing is associated with decreased physical activity, obesity and increased risk of hypertension (HTN). Master athletes (MA) have either pursued a physically active lifestyle throughout their life or initiated exercise or sport later in life. We assessed resting blood pressure (BP) in male and female World Masters Games (WMG) athletes. This was a cross-sectional, observational study which utilized an online survey to assess the blood pressure (BP) and other physiological parameters. Results: a total of 2793 participants were involved in this study. Key findings included differences between genders with males reporting higher resting SBP (+9.4%, \u3c 0.001), resting DBP (+5.9%, \u3c 0.001) and mean arterial pressure (+6.2%, \u3c 0.001). Significant differences ( \u3c 0.001) were also identified when comparing WMG athletes\u27 resting BP results (genders combined) to the general Australian population with WMG athletes having a lower SBP ( \u3c 0.001, -8.4%) and DBP ( \u3c 0.001, -3.6%). Additionally, 19.9% of males and 49.7% of female WMG participants were normotensive whereas 35.7% of the general Australian population were normotensive. Only 8.1% of the WMG athletes (genders combined) were found to be HTN compared to 17.2% in the general Australian population. These findings reflect a low prevalence of HTN in WMG participants and support our hypothesis of a low prevalence of HTN in an active, but aged cohort of MA

Multiple marker abundance profiling:combining selected reaction monitoring and data-dependent acquisition for rapid estimation of organelle abundance in subcellular samples

Measuring changes in protein or organelle abundance in the cell is an essential, but challenging aspect of cell biology. Frequently-used methods for determining organelle abundance typically rely on detection of a very few marker proteins, so are unsatisfactory. In silico estimates of protein abundances from publicly available protein spectra can provide useful standard abundance values but contain only data from tissue proteomes, and are not coupled to organelle localization data. A new protein abundance score, the normalized protein abundance scale (NPAS), expands on the number of scored proteins and the scoring accuracy of lower-abundance proteins in Arabidopsis. NPAS was combined with subcellular protein localization data, facilitating quantitative estimations of organelle abundance during routine experimental procedures. A suite of targeted proteomics markers for subcellular compartment markers was developed, enabling independent verification of in silico estimates for relative organelle abundance. Estimation of relative organelle abundance was found to be reproducible and consistent over a range of tissues and growth conditions. In silico abundance estimations and localization data have been combined into an online tool, multiple marker abundance profiling, available in the SUBA4 toolbox (http://suba.live)

Endurance masters athletes: a model of successful ageing and consequently reduced risk for chronic disease?

Master athletes (35 years and older) are aged individuals who exercise regularly and compete in organised competitive sport. The long-term physical activity/exercise should afford these individuals health benefits, one of which should be apparent in body mass index (BMI), a simple index for identifying overweight and obese athletes. Purpose: To investigate the BMI of endurance masters athletes and determine if this cohort demonstrated clinically favourable BMI as compared to sedentary controls or the general population. Methods: Systematic review of electronic databases (CINAHL, Cochrane, Medline, PubMed, PsycINFO, Scopus, Web of Science) for studies where BMI was measured in either masters athletes, World Masters Games (WMG) athletes or veteran athletes. Results: Database searches identified 7,465 studies, of which nine met our inclusion criteria. The mean BMI of all the studies was found to be significantly (p\u3c0.001) lower in masters athletes as compared to controls (23.4 kg/m2 (±0.97) versus 26.3 kg/m2 (±1.68)). Additionally, for all studies mean masters athlete BMI was classified as normal (BMI \u3e18.5 to \u3c25 kg/m2) whereas the majority (77.8%) of the controls BMIs were classified as overweight (BMI \u3e25 to \u3c 30 kg/m2). In all studies, masters athletes had lower BMI compared to controls, this difference was found to be significant in 44.4% of the studies, where significance was not found masters athlete BMI was -2.6% to -18.6% lower than controls. Conclusion: In all studies, the mean BMI was lower in masters athletes (as compared to controls) and this favourable BMI would afford masters athletes reduced risk with regard to the development of a number of cardiometabolic diseases, osteoarthritis and certain types of cancer

Cardiovascular risk profiles of world masters games participants

BACKGROUND: Increasing evidence indicates adherence to exercise throughout life is concurrent with improved health. World masters games (WMG) have more participants than any other international sporting competition and is under investigated, particularly with regard to indices of cardiovascular disease risk. Therefore, we chose to investigate selected cardiovascular risk factors in WMG participants. METHODS: This was a cross-sectional, observational study which utilized a web-based questionnaire to survey cardiovascular risk factors of WMG participants. The survey consisted of three sections: basic demographics, medical history and physiological parameters which included Body Mass Index (BMI), waist circumference (WC), resting blood pressure (BP) and lipids (total cholesterol [TC], high density lipoprotein [HDL] and low density lipoprotein [LDL]).RESULTS: A total of 1435 participants, 872 male, aged 27-91 years (mean age 54.99 years) participated in the study. Key findings included significant differences (PCONCLUSIONS: A high percentage of WMG participants demonstrated optimal values in a number of cardiovascular disease (CVD) risk factors when compared to the general population, female WMG participants had better values as compared to males. This reflected a decreased CVD in WMG participants and supports our hypothesis of enhanced health characteristics in an active, but aged cohort

Resting Blood Pressure in Master Athletes: Immune from Hypertension?

Ageing is associated with decreased physical activity, obesity and increased risk of hypertension (HTN). Master athletes (MA) have either pursued a physically active lifestyle throughout their life or initiated exercise or sport later in life. We assessed resting blood pressure (BP) in male and female World Masters Games (WMG) athletes. This was a cross-sectional, observational study which utilized an online survey to assess the blood pressure (BP) and other physiological parameters. Results: a total of 2793 participants were involved in this study. Key findings included differences between genders with males reporting higher resting SBP (+9.4%, p p p p p p < 0.001, −3.6%). Additionally, 19.9% of males and 49.7% of female WMG participants were normotensive whereas 35.7% of the general Australian population were normotensive. Only 8.1% of the WMG athletes (genders combined) were found to be HTN compared to 17.2% in the general Australian population. These findings reflect a low prevalence of HTN in WMG participants and support our hypothesis of a low prevalence of HTN in an active, but aged cohort of MA

Measurement of the orientation of buffer-gas-cooled, electrostatically-guided ammonia molecules

The files include the REMPI scans, PGOPHER simulations, model of the experimental apparatus and simulated state populations as described in the accompanying Journal of Molecular Spectroscopy publication