306 research outputs found
Reading, writing and apprenticeships: developing an authentic reading and assessment strategy for graduate apprenticeships.
The recent launch of graduate apprenticeships in Scotland requires participating universities to collaborate closely with employers to design and develop innovative curricula to enable apprentices to acquire new knowledge and develop relevant skills both in a traditional university learning and teaching setting as well as in the workplace. This paper argues that the additional context of learning situated in the workplace provides a particular impetus to consider and reflect the requirement and deployment of authentic reading strategies and authentic assessment regimes as essential design elements in these programmes. We present a discussion of the approach we are adopting to designing curricula and preparing learning and assessment resources for graduate apprenticeships in Business Management and Business Management: Financial Services. We focus here specifically on our plans for helping apprentices on these programmes to navigate the plethora of information resources available to them and develop effective reading strategies and information literacy skills in both academic and professional contexts. We indicate how the enhancement of these skills forms an important precursor to tackling the authentic assessments designed for apprentices to evidence their professional and academic learning during their apprenticeships. Our planning and design activity draws first on aspects of our recent research into reading skills and strategies among professionals and business students, as well as on our established track record of delivering a variety of work-based learning programmes. It is envisaged that findings and lessons learned from our work will help guide and inform other institutions across the UK as they establish curricula for graduate or degree apprenticeships
'Tempo doeloe' and 'Pudjangga Baru' : aspects of social and intellectual life in twentieth-century Batavia, focussing on the Indonesian community 1933 to 1942
"Tempo Doeloeu" is the Dutch transcription of a
Malay phrase meaning âtime pastâ, an expression often used
hy ex-colonial officials, returned from Java or the Outer
Islands, to refer to that time when Holland had the Dutch
East Indies. It is a nostalgic expression, evocative of
tiled houses and bamboo chairs, servants in tight white
collars, Balinese carvings and Dutch wives.1 Pudjangga
Baru, the âNew Writerâ or âNew Man of Lettersâ, was a
cultural periodical published in Batavia (Djakarta) between
1933 and 1942 by a group of Indonesian intellectuals.
These idealistic young men wrote and worked to give form
to their ideas of a national Indonesian language, literature and culture; their eyes were on the future
Sorting âNativesâ from âIndiansâ : interrogating historic burials in the Catholic Burying Ground on the Dartmouth Common (1835-1865)
vi, 111 leaves : illustrations (some colour), colour map ; 29 cmIncludes abstract and appendices.Includes bibliographical references (leaves 100-111).This research disrupts a colonial narrative about settlers and hundreds of âIndiansâ inscribed on a monument as part of a non-Indigenous tourism scheme to raise money and clean up the abandoned Catholic Burying Ground on the Dartmouth Common. Many Natives of Ireland and others, not Natives of North America, are identified by a detailed analysis of handwritten death records and other sources. They were all but forgotten when the municipality took control of the cemetery in 1975 without a copy of the church records. This left a gap in public memory that allowed variations of an âold Indian burial groundâ narrative to evolve from burials in the ground (1962) to burials in a mound (2010). The findings are relevant to the national project of Truth and Reconciliation and serve as a cautionary tale about the importance of seeking truth before reconciliation. This research will be of interest to Irish researchers and descendants of those who died; residents of Halifax Regional Municipality who own the cemetery in trust; government administrators, planners, and surveyors; Catholic organizations in control of historic records; and to social, legal and Indigenous researchers who grapple with constructed âIndianâ identities as a way of decolonizing the story of Canada
Thinking differently about âstudent mental health and wellbeingâ â learning from undergraduatesâ storied âuniversity lifeâ self-reflections
Background: Increasing rates of university student mental distress are being recorded; continuation of this upward trend remains apparent. Current explorations of studentsâ mental health and wellbeing primarily use quantitative approaches, contributing to significant gaps in qualitative understanding.
Aim: To explore undergraduates' accounts and self-reflections regarding their own mental health and wellbeing within their overall experiences of student life.
Methodological Approach: After in-depth examination of key definitions and perspectives traditionally underpinning research in this area, and drawing on elements of suicide loss lived experience, principles guiding the Power, Threat, Meaning Framework, and sociological perspectives on affect and emotion were together used as the research design lens. Free Association Narrative interviews fronted by a social media elicitation task were employed to foreground studentsâ own storytelling and meaning-making in reference to their mental health, distress and wellbeing experiences. Each participant engaged in interviews at two timepoints in 2020 and 2021.
Analysis: Twenty-one undergraduates at a university in the Northeast of the UK participated. Through data analysis using reflexive thematic analysis, identified were parallel-running and interweaving elements in the studentsâ mental health, distress and wellbeing stories. First, within their âGeneral Lifeâ, students thematically located their experiences in their overall-life contexts in terms of âTimeâ; âPlace/Spaceâ; âRelationshipsâ; âLoss âand âMacro-level Threadsâ. Second, within their âUniversity Lifeâ, stories displayed mental health, distress and wellbeing aspects connected to particular elements of their university; the themes presented are âInstitution-led Mechanisms, Systems and Proceduresâ; âUniversity-bordered Relationshipsâ; âUniversity as a Mirrorâ and âUniversity-Specific Meanings, Perceptions and Expectationsâ. Third, uniting studentsâ general and university lives and experiences, their âFelt Lifeâ was explored â common emotion underpinnings to their mental health, distress and wellbeing experiences comprised of three key sentiments: âFeeling in Controlâ; âFeeling Secureâ and âFeeling Recognisedâ.
Contribution: The contribution of this thesis is multi-pronged. The methodological approach employed demonstrates the importance of over-time and multi-level qualitative engagement with students as key to making visible what may be obscured by continued reliance on traditional data collection methods. Turning to the content, offered here are two elements; first, a different, wider-contextual understanding on risk factors for negative student mental health and wellbeing, and second, a theoretical framework of the emotions that underpin student mental health and wellbeing risk factors. The emotional undercurrents to university-connected mental health, distress and wellbeing experiences are insightful as an important, yet at present still under-appreciated, aspect of student mental health and wellbeing. The thesis encourages review of existing in-response university support approaches and mechanisms (in specific reference to, for example, student bereavements and study programs including placements) in light of such findings. Cumulatively, this research overall acts as an invitation to augment existing perspectives and approaches to university student mental health, distress and wellbeing through re-evaluation and discussion regarding how these may be conceptualised differently and alternatively understood
Investigating the adoption of sustainable green initiatives in Scottish food and drink SMEs.
Increasing concerns towards environmental issues (transportation emissions, global warming, depletion of natural resources) in today's global economy has resulted in the need for businesses to be more environmentally friendly and act in an environmentally responsible manner. Like most developed nations, the UK has placed significant importance on the need for more sustainable business operations. However the smooth adoption and implementation of these green practices by businesses is slow due to challenges such as lack of awareness, cost, resourcing, legislation, and incorporation into existing business processes. Green practices are often assumed by SMEs to involve significant expense, and in some cases even unaffordable. Particularly during the recent time of recession, focus has been on keeping SMEs afloat rather than making substantial investment in what are perceived to be 'nice to have' green initiatives. SMEs sometimes also cite lack of knowledge of how to implement green initiatives and lack of support for such activity. The focus of this research is Scottish food and drink sector, which plays a vital role contributing nearly {pound}10bn yearly to the economy. However, this positive contribution of the sector to the economy sits in tension with the fact it also generates a substantial amount of waste (estimated to generate 2 million tonnes of waste annually), and thus has costly negative impacts on the environment. This paper forms part of a larger doctoral study on green supply chain initiatives in Scottish SMEs. Specifically, the research has been set up to explore the various factors motivating and inhibiting the adoption of green initiatives by food and drink businesses. In this paper, the focus is on a review of the literature that was undertaken to establish some initial motivators and inhibitors among SMEs across a range of sectors. These were then explored further in a pilot study among six small firms in the food and drink sector Scotland. This qualitative pilot study was undertaken using semi-structured interviews with the owner-managers. Arising from the findings of the pilot study, a scale of 'green-ness' was devised to chart the extent to which the firms have innovated by incorporating green practices into their business processes. A more extensive study is now being designed to test and refine the scale with a view to creating a model to assist small businesses in their planning and strategizing in relation to introducing green practices. The paper reports on the early stages of this research, including the pilot study and the creation of the 'green-ness' scale
Selinexor-Based Triplet Regimens in Patients With Multiple Myeloma Previously Treated With Anti-CD38 Monoclonal Antibodies
High-risk; Oral selective inhibitor of nuclear export; Relapsed/refractoryAlto riesgo; Inhibidor selectivo oral de la exportaciĂłn nuclear; RecaĂda/refractarioAlt risc; Inhibidor selectiu oral de l'exportaciĂł nuclear; Recaiguda/refractariBackground
The increasing use of anti-CD38 monoclonal antibodies (αCD38 mAbs) for newly diagnosed or early relapsed multiple myeloma (MM), especially in non-transplant eligible patients, may lead to more patients developing αCD38 mAb-refractory disease earlier in the treatment course with fewer treatment options.
Patients and methods
We analyzed the efficacy and safety of selinexor-based triplets (selinexor+dexamethasone [Sd] plus pomalidomide [SPd, n = 23], bortezomib [SVd, n = 16] or carfilzomib (SKd, n = 23]) in a subset of STOMP (NCT02343042) and BOSTON (NCT03110562) study patients treated previously with αCD38 mAbs.
Results
Sixty-two patients (median 4 prior therapies, range 1 to 11, 90.3% refractory to αCD38 mAb) were included. Overall response rates (ORR) in the SPd, SVd and SKd cohorts were 52.2%, 56.3%, and 65.2%, respectively. Overall response rate was 47.4% among patients who had MM refractory to the third drug reintroduced in the Sd-based triplet. Median progression-free survival in the SPd, SVd, and SKd cohorts was 8.7, 6.7, and 15.0 months, respectively, and median overall survival was 9.6, 16.9, and 33.0 months, respectively. Median time to discontinuation in the SPd, SVd, and SKd cohorts was 4.4, 5.9, and 10.6 months, respectively. The most common hematological adverse events were thrombocytopenia, anemia, and neutropenia. Nausea, fatigue, and diarrhea were primarily grade 1/2. Adverse events were generally manageable with standard supportive care and dose modifications.
Conclusion
Selinexor-based regimens may offer effective and well-tolerated therapy to patients with relapsed and/or refractory MM who had disease previously exposed or refractory to αCD38 mAb therapy and could help address the unmet clinical need in these high-risk patients
Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
The extensive glycosylation of HIV-1 envelope proteins (Env), gp120/gp41, is known to play an important role in evasion of host immune response by masking key neutralization epitopes and presenting the Env glycosylation as âselfâ to the host immune system. The Env glycosylation is mostly conserved but continues to evolve to modulate viral infectivity. Thus, profiling Env
glycosylation and distinguishing interclade and intraclade glycosylation variations are necessary components in unraveling the effects of glycosylation on Envâs immunogenicity. Here, we describe a mass spectrometry-based approach to characterize the glycosylation profiles of two rVV-expressed clade C Envs by identifying the glycan motifs on each glycosylation site and determining the degree of glycosylation site occupancy. One Env is a wild-type Env, while the other is a synthetic âconsensusâ sequence (C.CON). The observed differences in the glycosylation profiles between the two clade C Envs show that C.CON has more unutilized sites and high levels of high mannose glycans; these features mimic the glycosylation profile of a Group M consensus immunogen, CONS. Our results also reveal a clade-specific glycosylation pattern. Discerning interclade and intraclade glycosylation variations could provide valuable information in understanding the molecular differences among the different HIV-1 clades and in designing new Env-based immunogens
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