Driving Revenue For Organizations Through Multiple Sales Channels

This research paper focuses on the sales industry from how sales became a profession to sales as we know it today. Driving revenue is the main goal of a for profit company or organization and how this goal can be achieved using one or more sales channels will be discussed within this research. This research seeks to determine if by utilizing multiple sales channels within an organization to sell its products and services, is that organization more profitable as they have more avenues to be able to reach more potential customers? While there are many sales channels that can be used to drive revenue for an organization, the two most common sales channels used today are direct sales channels and indirect sales channels. The success of the organization, the leadership team, and the sales team will depend on multiple variables discussed within this research such as hiring and keeping the right salespeople within the organization, the traits of great salespeople as well as the benefits and downsides to having multiple sales channels. The COVID-19 pandemic and its effects on the sales industry as well as the future of the sales industry will also be discussed within this research. Keywords: sales, direct sales, indirect sales, channel sales, sales channel

Pedagogical interchanges on identity : an email correspondence

vi, 54 leaves ; 29 cm. --A series of fifteen email interchanges provided a qualitative research environment in which to engage in authentic communication about the people and events that have shaped my correspondent and me as both teachers and learners, and provided us with the opportunity to share, and to reflect on, the same roles as school administrators. In telling the stories of our personal and working lives, we examined, and better understood, the experiences that have shaped our identities. The purpose of the project was to explore what our lifewriting reveals to us about our identity. It brought to light the learning that takes place as we reconsidered our views of our educational experiences, parent-child relationships, and our own professional working realities. In doing this project, I wanted to find out what it was about the history of my life that made me choose the path of teacher, and then the one of administrator, and shaped my identity in these roles. I wanted to recognize and understand the effects of the people, events, and themes that shaped my identity, and continue to shape my identity in those roles and in others. I was most interested in the journey, the dynamics of the letter writing relationship, the themes that surfaced in our writing, and the insights the interchanges would provide

Differentiation of Gram-Negative Bacterial Aerosol Exposure Using Detected Markers in Bronchial-Alveolar Lavage Fluid

The identification of biosignatures of aerosol exposure to pathogens has the potential to provide useful diagnostic information. In particular, markers of exposure to different types of respiratory pathogens may yield diverse sets of markers that can be used to differentiate exposure. We examine a mouse model of aerosol exposure to known Gram negative bacterial pathogens, Francisella tularensis novicida and Pseudomonas aeruginosa. Mice were subjected to either a pathogen or control exposure and bronchial alveolar lavage fluid (BALF) was collected at four and twenty four hours post exposure. Small protein and peptide markers within the BALF were detected by matrix assisted laser desorption/ionization (MALDI) mass spectrometry (MS) and analyzed using both exploratory and predictive data analysis methods; principle component analysis and degree of association. The markers detected were successfully used to accurately identify the four hour exposed samples from the control samples. This report demonstrates the potential for small protein and peptide marker profiles to identify aerosol exposure in a short post-exposure time frame

T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair

While it is well known that the presence of lymphocytes and cytokines are important for fracture healing, the exact role of the various cytokines expressed by cells of the immune system on osteoblast biology remains unclear. To study the role of inflammatory cytokines in fracture repair, we studied tibial bone healing in wild-type and Rag1−/− mice. Histological analysis, µCT stereology, biomechanical testing, calcein staining and quantitative RNA gene expression studies were performed on healing tibial fractures. These data provide support for Rag1−/− mice as a model of impaired fracture healing compared to wild-type. Moreover, the pro-inflammatory cytokine, IL-17F, was found to be a key mediator in the cellular response of the immune system in osteogenesis. In vitro studies showed that IL-17F alone stimulated osteoblast maturation. We propose a model in which the Th17 subset of T-lymphocytes produces IL-17F to stimulate bone healing. This is a pivotal link in advancing our current understanding of the molecular and cellular basis of fracture healing, which in turn may aid in optimizing fracture management and in the treatment of impaired bone healing

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

<p>Abstract</p> <p>Background</p> <p>Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an important regulator of genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1 and peroxiredoxin 1, by activating the antioxidant response element (ARE). We <it>hypothesized </it>that (1) the citrus coumarin auraptene may suppress premalignant mammary lesions via activation of Nrf2/ARE, and (2) that Nrf2 knockout (KO) mice would be more susceptible to mammary carcinogenesis.</p> <p>Methods</p> <p>Premalignant lesions and mammary carcinomas were induced by medroxyprogesterone acetate and 7,12-dimethylbenz[a]anthracene treatment. The 10-week pre-malignant study was performed in which 8 groups of 10 each female wild-type (WT) and KO mice were fed either control diet or diets containing auraptene (500 ppm). A carcinogenesis study was also conducted in KO vs. WT mice (n = 30-34). Comparisons between groups were evaluated using ANOVA and Kaplan-Meier Survival statistics, and the Mann-Whitney U-test.</p> <p>Results</p> <p>All mice treated with carcinogen exhibited premalignant lesions but there were no differences by genotype or diet. In the KO mice, there was a dramatic increase in mammary carcinoma growth rate, size, and weight. Although there was no difference in overall survival, the KO mice had significantly lower mammary tumor-free survival. Also, in the KO mammary carcinomas, the active forms of NF-κB and β-catenin were increased ~2-fold whereas no differences in oxidized proteins were observed. Many other tumors were observed, including lymphomas. Interestingly, the incidences of lung adenomas in the KO mice were significantly higher than in the WT mice.</p> <p>Conclusions</p> <p>We report, for the first time, that there was no apparent difference in the formation of premalignant lesions, but rather, the KO mice exhibited rapid, aggressive mammary carcinoma progression.</p

Regenerating the sampling interface of modular chemical sensing systems

Thesis (Ph. D.)--University of Washington, 2002This dissertation describes modular chemical sensing systems (MCSS) and how the sampling interfaces of these systems can be regenerated. By regenerating the sampling interface, the reproducibility of the sensing system's measurements can be improved over traditional stationary sampling interfaces. The first modular chemical sensing system explored in this work is a chemiluminescent biosensor with fiber optic detection. The concept of in situ replacement the part of the sensor that imparted selectivity and pre-concentration, in this case the antibody layer, grew out of this work after conventional immobilization strategies failed and non-covalent immobilization was explored. This led to exploration of other systems or system components that can be regenerated to increase the stability of a chemical sensing system over time.These other systems include a dissolved oxygen sensing system for marine deployment, the liquid core waveguide, and supported liquid membrane sampling interfaces. The oxygen sensing system's sampling interface is an electrolyte-filled tubular membrane. The electrolyte is renewed with each measurement, thereby renewing the sampling interface of the system. Membrane biofouling is prevented by periodically illuminating the tube with UV radiation. The liquid core waveguide can be used as both a detector and sampling interface. It is a semi-permeable membrane in which the core material can be renewed with each measurement, regenerating the sampling interface. In addition, it is a long-path optical cell that can be used for sensitive absorbance-based or Raman detection. Supported liquid membranes were also explored in this work as a sampling interface for two sensing systems, the FlowProbe and the liquid core waveguide. Supported liquid membranes provide one-step extraction from a bulk matrix where the reagent acts as the sink for the extracted species. Renewing this reagent regenerates the sampling interface. Additionally, in situ replacement of the supported liquid membrane was explored

Solvent Extraction of Chemical Attribution Signature Compounds from Painted Wall Board: Final Report

This report summarizes work that developed a robust solvent extraction procedure for recovery of chemical attribution signature (CAS) compound dimethyl methyl phosphonate (DMMP) (as well as diethyl methyl phosphonate (DEMP), diethyl methyl phosphonothioate (DEMPT), and diisopropyl methyl phosphonate (DIMP)) from painted wall board (PWB), which was selected previously as the exposed media by the chemical attribution scientific working group (CASWG). An accelerated solvent extraction approach was examined to determine the most effective method of extraction from PWB. Three different solvent systems were examined, which varied in solvent strength and polarity (i.e., 1:1 dichloromethane : acetone,100% methanol, and 1% isopropanol in pentane) with a 1:1 methylene chloride : acetone mixture having the most robust and consistent extraction for four original target organophosphorus compounds. The optimum extraction solvent was determined based on the extraction efficiency of the target analytes from spiked painted wallboard as determined by gas chromatography x gas chromatography mass spectrometry (GCxGC-MS) analysis of the extract. An average extraction efficiency of approximately 60% was obtained for these four compounds. The extraction approach was further demonstrated by extracting and detecting the chemical impurities present in neat DMMP that was vapor-deposited onto painted wallboard tickets

Supplemental Material - Contexts and Characteristics of Imaged-Based Sexual Exploitation and Abuse of Children: Incident Dynamics in a National Sample

Supplemental Material for Contexts and Characteristics of Imaged-Based Sexual Exploitation and Abuse of Children: Incident Dynamics in a National Sample by Heather Turner, David Finkelhor, and Deirdre Colburn in Child Maltreatment</p

Central auditory masking by an illusory tone

Many natural sounds fluctuate over time. The detectability of sounds in a sequence can be reduced by prior stimulation in a process known as forward masking. Forward masking is thought to reflect neural adaptation or neural persistence in the auditory nervous system, but it has been unclear where in the auditory pathway this processing occurs. To address this issue, the present study used a "Huggins pitch" stimulus, the perceptual effects of which depend on central auditory processing. Huggins pitch is an illusory tonal sensation produced when the same noise is presented to the two ears except for a narrow frequency band that is different (decorrelated) between the ears. The pitch sensation depends on the combination of the inputs to the two ears, a process that first occurs at the level of the superior olivary complex in the brainstem. Here it is shown that a Huggins pitch stimulus produces more forward masking in the frequency region of the decorrelation than a noise stimulus identical to the Huggins-pitch stimulus except with perfect correlation between the ears. This stimulus has a peripheral neural representation that is identical to that of the Huggins-pitch stimulus. The results show that processing in, or central to, the superior olivary complex can contribute to forward masking in human listeners