The psychological toll of prostate cancer

© 2018, Springer Nature Limited. Matta et al. report that men with prostate cancer who underwent surgery or radiotherapy, but not active surveillance, had greater odds of receiving antidepressants than controls. However, methodological limitations preclude the interpretation of a psychological benefit for men on active surveillance. Screening for distress and referral to evidence-based intervention should be a priority

Prostate cancer survivorship care: if not now, when?

Prostate cancer is the most common cancer diagnosed in Australian men, excluding non-melanoma skin cancer, and it is estimated that there are over 220 000 Australian men living with a diagnosis of prostate cancer [1]. Survival for men with prostate cancer is excellent in countries that have accessible screening and treatment services, and in Australia 5-year relative survival is over 95% [1]. High incidence, coupled with improving long-term survival, leads to a correspondingly high prevalence rate and high community disease burden. Many men with prostate cancer experience long-term decrements in their mental and physical quality of life, overall they have a greater suicide risk than their non-cancer peers, and unmet supportive care needs are pervasive [2]. In this context, survivorship care for men with prostate cancer is crucial in both the short and long term. The recent development of a Prostate Cancer Survivorship Essentials Framework in the Australian and New Zealand setting provides an example of a regional response to this issue that delivers guidance for policy makers, clinicians, community and consumers on what is essential for step change in prostate cancer survivorship outcomes [3]

Photometric study of southern SU UMa-type dwarf novae and candidates -- III: NSV 10934, MM Sco, AB Nor, CAL 86

We photometrically observed four southern dwarf novae in outburst (NSV 10934, MM Sco, AB Nor and CAL 86). NSV 10934 was confirmed to be an SU UMa-type dwarf nova with a mean superhump period of 0.07478(1) d. This star also showed transient appearance of quasi-periodic oscillations (QPOs) during the final growing stage of the superhumps. Combined with the recent theoretical interpretation and with the rather unusual rapid terminal fading of normal outbursts, NSV 10934 may be a candidate intermediate polar showing SU UMa-type properties. The mean superhump periods of MM Sco and AB Nor were determined to be 0.06136(4) d and 0.08438(2) d, respectively. We suggest that AB Nor belongs to a rather rare class of long-period SU UMa-type dwarf novae with low mass-transfer rates. We also observed an outburst of the suspected SU UMa-type dwarf nova CAL 86. We identified this outburst as a normal outburst and determined the mean decline rate of 1.1 mag/d.Comment: 13 pages, 23 figures, to appear in MNRAS. For more information, see http://www.kusastro.kyoto-u.ac.jp/vsnet

How Does a Delay Between Temperate Running Exercise and Hot-Water Immersion Alter the Acute Thermoregulatory Response and Heat-Load?

Hot-water immersion following exercise in a temperate environment can elicit heat acclimation in endurance-trained individuals. However, a delay between exercise cessation and immersion is likely a common occurrence in practice. Precisely how such a delay potentially alters hot-water immersion mediated acute physiological responses (e.g., total heat-load) remains unexplored. Such data would aid in optimizing prescription of post-exercise hot-water immersion in cool environments, relative to heat acclimation goals. Twelve male recreational runners (mean ± SD; age: 38 ± 13 years, height: 180 ± 7 cm, body mass: 81 ± 13.7 kg, body fat: 13.9 ± 3.5%) completed three separate 40-min treadmill runs (18°C), followed by either a 10 min (10M), 1 h (1H), or 8 h (8H) delay, prior to a 30-min hot-water immersion (39°C), with a randomized crossover design. Core and skin temperatures, heart rate, sweat, and perceptual responses were measured across the trials. Mean core temperature during immersion was significantly lower in 1H (37.39 ± 0.30°C) compared to 10M (37.83 ± 0.24°C; p = 0.0032) and 8H (37.74 ± 0.19°C; p = 0.0140). Mean skin temperature was significantly higher in 8H (32.70 ± 0.41°C) compared to 10M (31.93 ± 0.60°C; p = 0.0042) at the end of the hot-water immersion. Mean and maximal heart rates were also higher during immersion in 10M compared to 1H and 8H (p < 0.05), despite no significant differences in the sweat or perceptual responses. The shortest delay between exercise and immersion (10M) provoked the greatest heat-load during immersion. However, performing the hot-water immersion in the afternoon (8H), which coincided with peak circadian body temperature, provided a larger heat-load stimulus than the 1 h delay (1H)

Donut: measuring optical aberrations from a single extra-focal image

We propose a practical method to calculate Zernike aberrations from analysis of a single long-exposure defocused stellar image. It consists in fitting the aberration coefficients and seeing blur directly to a realistic image binned into detector pixels. This "donut" method is different from curvature sensing in that it does not make the usual approximation of linearity. We calculate the sensitivity of this technique to detector and photon noise and determine optimal parameters for some representative cases. Aliasing of high-order un-modeled aberrations is evaluated and shown to be similar to a low-order Shack-Hartmann sensor. The method has been tested with real data from the SOAR and Blanco 4m telescopes.Comment: 13 pages, 9 figures. Accepted at PAS

Dystroglycan Overexpression in Vivo Alters Acetylcholine Receptor Aggregation at the Neuromuscular Junction

AbstractDystroglycan is a member of the transmembrane dystrophin glycoprotein complex in muscle that binds to the synapse-organizing molecule agrin. Dystroglycan binding and AChR aggregation are mediated by two separate domains of agrin. To test whether dystroglycan plays a role in receptor aggregation at the neuromuscular junction, we overexpressed it by injecting rabbit dystroglycan RNA into one- or two-celled Xenopus embryos. We measured AChR aggregation in myotomes by labeling them with rhodamine–α-bungarotoxin followed by confocal microscopy and image analysis. Dystroglycan overexpression decreased AChR aggregation at the neuromuscular junction. This result is consistent with dystroglycan competition for agrin without signaling AChR aggregation. It also supports the hypothesis that dystroglycan is not the myotube-associated specificity component, (MASC) a putative coreceptor needed for agrin to activate muscle-specific kinase (MuSK) and signal AChR aggregation. Dystroglycan was distributed along the surface of muscle membranes, but was concentrated at the ends of myotomes, where AChRs normally aggregate at synapses. Overexpressed dystroglycan altered AChR aggregation in a rostral–caudal gradient, consistent with the sequential development of neuromuscular synapses along the embryo. Increasing concentrations of dystroglycan RNA did not further decrease AChR aggregation, but decreased embryo survival. Development often stopped during gastrulation, suggesting an essential, nonsynaptic role of dystroglycan during this early period of development

SN 1987A's Circumstellar Envelope, II: Kinematics of the Three Rings and the Diffuse Nebula

We present several different measurements of the velocities of structures within the circumstellar envelope of SN 1987A, including the inner, equatorial ring (ER), outer rings (ORs), and the diffuse nebulosity at radii < 5 pc, based on CTIO 4m and HST data. A comparison of STIS and WFPC2 [N II]6583 loci for the rings show that the ER is expanding in radius at 10.5+-0.3 km/s, with the northern OR expanding along the line of sight at about 26 km/s, and for the southern OR, about 23 km/s. Similar results are found with CTIO 4m data. Accounting for inclination, the best fit to all data show both ORs with an expansion from the SN of 26 km/s. The ratio of the ER to OR velocities is nearly equal to the ratio of ER to OR radii, so the rings are roughly homologous, all having kinematic ages corresponding to about 20,000 yr before the SN explosion. This makes previously reported, large compositional differences between the ER and ORs difficult to understand. Additionally, a grid of longslit 4m/echelle spectra centered on the SN shows two velocity components over a region roughly coextensive with the outer circumstellar envelope extending about 5 pc (20 arcsec) from the SN. One component is blueshifted and the other redshifted from the SN centroid by about 10 km/s each. These features may represent a bipolar flow expanding from the SN, in which the ORs are propelled 10-15 km/s faster than that of the surrounding envelope into which they propogate. The kinematic timescale for the entire nebula is at least about 350,000 yr. The kinematics of these various structures constrain possible models for the evolution of the progenitor and its formation of a mass loss nebula.Comment: 25 pages AASTeX text plus 12 figures. ApJ, in pres