9,231 research outputs found
On the Security of Millimeter Wave Vehicular Communication Systems using Random Antenna Subsets
Millimeter wave (mmWave) vehicular communica tion systems have the potential
to improve traffic efficiency and safety. Lack of secure communication links,
however, may lead to a formidable set of abuses and attacks. To secure
communication links, a physical layer precoding technique for mmWave vehicular
communication systems is proposed in this paper. The proposed technique
exploits the large dimensional antenna arrays available at mmWave systems to
produce direction dependent transmission. This results in coherent transmission
to the legitimate receiver and artificial noise that jams eavesdroppers with
sensitive receivers. Theoretical and numerical results demonstrate the validity
and effectiveness of the proposed technique and show that the proposed
technique provides high secrecy throughput when compared to conventional array
and switched array transmission techniques
Synthetic DNA immunotherapy in biochemically relapsed prostate cancer
Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts).
Methods: Phase I, open-label, multi-center study in the US included pts with rising PSA after surgery and/or RT, PSA doubling time (PSADT) \u3e3 months (mos), testosterone \u3e150 ng/dL and no concurrent ADT. Safety, immunogenicity and efficacy (PSA kinetics, PFS) were evaluated in 4 treatment arms of 15 pts each. Arms A: 2mg INO-5150, B: 8.5 mg INO-5150, C: 2mg INO-5150 + 1mg INO-9012 and D: 8.5mg INO-5150 + 1mg INO-9012. Pts received 4 IM doses of vaccine followed by electroporation on day 0, wks 3, 12 and 24 and were followed for 72 wks.
Results: 50/61 (82%) pts completed all visits and treatments were well tolerated with no safety concerns. Median PFS for overall population [N = 61, baseline (D0) PSADT range (mos) 1.5-217.1, median 9.8] and for a subset of pts with D0 PSADT ≤12mos (N = 36) has not yet been reached (FU 3-19 mos). 86% of pts with D0 PSADT ≤12 mos were progression free through 19mos FU. 27 out of 36 (75%) pts with D0 PSADT≤ 12 mos had disease stabilization at wks 27 evidenced by significant improvement in log2PSA change over time (slope) and PSADT from D0 (Slope=0.19 declined to 0.1, PSADT=5.3 improved to 10.1 mos, p = \u3c0.0001). This effect was maintained at wk 72 (Slope=0.09, PSADT=10.6, p = \u3c0.0001). Immunogenicity was observed in 77% (47/61) of pts by multiple immunologic assessments. Patient immunogenicity to INO-5150 as determined by CD38 and Perforin + CD8 T cell immune reactivity correlated with attenuated % PSA rise compared to pts without reactivity (p = 0.05, n = 50).
Conclusions: INO-5150 +/- INO-9012 was safe, well tolerated and immunogenic. Clinical efficacy was observed in the patients with D0 PSADT≤ 12 mos as evidenced by a significant dampening of log2PSA change over time and increased PSADT up to 72 weeks FU. Additional genomic analyses are ongoing to further elucidate the correlation of immunologic efficacy and clinical benefit. (NCT02514213)
End-to-End Joint Antenna Selection Strategy and Distributed Compress and Forward Strategy for Relay Channels
Multi-hop relay channels use multiple relay stages, each with multiple relay
nodes, to facilitate communication between a source and destination.
Previously, distributed space-time codes were proposed to maximize the
achievable diversity-multiplexing tradeoff, however, they fail to achieve all
the points of the optimal diversity-multiplexing tradeoff. In the presence of a
low-rate feedback link from the destination to each relay stage and the source,
this paper proposes an end-to-end antenna selection (EEAS) strategy as an
alternative to distributed space-time codes. The EEAS strategy uses a subset of
antennas of each relay stage for transmission of the source signal to the
destination with amplify and forwarding at each relay stage. The subsets are
chosen such that they maximize the end-to-end mutual information at the
destination. The EEAS strategy achieves the corner points of the optimal
diversity-multiplexing tradeoff (corresponding to maximum diversity gain and
maximum multiplexing gain) and achieves better diversity gain at intermediate
values of multiplexing gain, versus the best known distributed space-time
coding strategies. A distributed compress and forward (CF) strategy is also
proposed to achieve all points of the optimal diversity-multiplexing tradeoff
for a two-hop relay channel with multiple relay nodes.Comment: Accepted for publication in the special issue on cooperative
communication in the Eurasip Journal on Wireless Communication and Networkin
Infection programs sustained lymphoid stromal cell responses and shapes lymph node remodeling upon secondary challenge
Published: January 10, 2017Lymph nodes (LNs) are constructed of intricate networks of endothelial and mesenchymal stromal cells. How these lymphoid stromal cells (LSCs) regulate lymphoid tissue remodeling and contribute to immune responses remains poorly understood. We performed a comprehensive functional and transcriptional analysis of LSC responses to skin viral infection and found that LSC subsets responded robustly, with different kinetics for distinct pathogens. Recruitment of cells to inflamed LNs induced LSC expansion, while B cells sustained stromal responses in an antigen-independent manner. Infection induced rapid transcriptional responses in LSCs. This transcriptional program was transient, returning to homeostasis within 1 month of infection, yet expanded fibroblastic reticular cell networks persisted for more than 3 months after infection, and this altered LN composition reduced the magnitude of LSC responses to subsequent heterologous infection. Our results reveal the complexity of LSC responses during infection and suggest that amplified networks of LN stromal cells support successive immune responses.Julia L. Gregory, Anne Walter, Yannick O. Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z. Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K. Mackay, Gordon K. Smyth, William R. Heath, and Scott N. Muelle
On the error term in Weyl's law for the Heisenberg manifolds (II)
In this paper we study the mean square of the error term in the Weyl's law of
an irrational -dimensional Heisenberg manifold . An asymptotic formula
is established
Modeling transport through single-molecule junctions
Non-equilibrium Green's functions (NEGF) formalism combined with extended
Huckel (EHT) and charging model are used to study electrical conduction through
single-molecule junctions. Analyzed molecular complex is composed of asymmetric
1,4-Bis((2'-para-mercaptophenyl)-ethinyl)-2-acetyl-amino-5-nitro-benzene
molecule symmetrically coupled to two gold electrodes [Reichert et al., Phys.
Rev. Lett. Vol.88 (2002), pp. 176804]. Owing to this model, the accurate values
of the current flowing through such junction can be obtained by utilizing basic
fundamentals and coherently deriving model parameters. Furthermore, the
influence of the charging effect on the transport characteristics is
emphasized. In particular, charging-induced reduction of conductance gap,
charging-induced rectification effect and charging-generated negative value of
the second derivative of the current with respect to voltage are observed and
examined for molecular complex.Comment: 8 pages, 3 figure
Quadratic BSDEs driven by a continuous martingale and application to utility maximization problem
In this paper, we study a class of quadratic Backward Stochastic Differential
Equations (BSDEs) which arises naturally when studying the problem of utility
maximization with portfolio constraints. We first establish existence and
uniqueness results for such BSDEs and then, we give an application to the
utility maximization problem. Three cases of utility functions will be
discussed: the exponential, power and logarithmic ones
- …