The control of a nuclear reactor using helium- 3 gas control elements

Control system for water moderated reactor using helium-3 ga

Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity

Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation. The maintenance of chromatin domain integrity can require the setting of boundaries. The HS4 insulator element marks the 3′ boundary of a heterochromatin region located upstream of the chicken β-globin gene cluster. Here we show that HS4 recruits the E3 ligase RNF20/BRE1A to mediate H2B mono-ubiquitination (H2Bub1) at this insulator. Knockdown experiments show that RNF20 is required for H2Bub1 and processive H3K4 methylation. Depletion of RNF20 results in a collapse of the active histone modification signature at the HS4 chromatin boundary, where H2Bub1, H3K4 methylation, and hyperacetylation of H3, H4, and H2A.Z are rapidly lost. A remarkably similar set of events occurs at the HSA/HSB regulatory elements of the FOLR1 gene, which mark the 5′ boundary of the same heterochromatin region. We find that persistent H2Bub1 at the HSA/HSB and HS4 elements is required for chromatin boundary integrity. The loss of boundary function leads to the sequential spreading of H3K9me2, H3K9me3, and H4K20me3 over the entire 50 kb FOLR1 and β-globin region and silencing of FOLR1 expression. These findings show that the HSA/HSB and HS4 boundary elements direct a cascade of active histone modifications that defend the FOLR1 and β-globin gene loci from the pervasive encroachment of an adjacent heterochromatin domain. We propose that many gene loci employ H2Bub1-dependent boundaries to prevent heterochromatin spreading

Radioisotope thermionic power supply for spacecraft

Power supply design for unmanned electric propulsion missions to outer planets utilizes a store of curium-244 in compact array of capsules as energy source. Supply subassemblies are: heat source, converter equipment which supplies power, and safety equipment. System is designed for a 72,000 hour mission

Beverage Label--Dempsey Extra from W. C. Heath to Attorney General Langer, 1917

Beverage label--Dempsey Extra--sent by W. C. Heath to Attorney General William Langer in July of 1917.https://commons.und.edu/langer-papers/1229/thumbnail.jp

Beverage Label--Malta from W. C. Heath to Attorney General Langer, 1917

Beverage label--Malta--sent by W. C. Heath to Attorney General William Langer in July of 1917.https://commons.und.edu/langer-papers/1230/thumbnail.jp

Beverage Label--Nontoxo from W. C. Heath to Attorney General Langer, 1917

Beverage label--Nontoxo--sent by W. C. Heath to Attorney General William Langer in July of 1917https://commons.und.edu/langer-papers/1231/thumbnail.jp

Thermionic reactor power system: Effects of radiation on integration with Manned Space Station

The application of a thermionic reactor power system to the modular space station is described. The nominal net power is 40 kWe, with the power system designed to be applicable over the power range from 25 to 60 kWe. The power system is designed to be launched by the space shuttle. Radiation protection is provided by LiH neutron shielding and W gamma shielding in a shaped 4 pion configuration, i.e., the reactor is shielded on all sides but not to equal extent. Isodose contours are presented for the region around the modular space station. Levels and spectral distribution of radiation are given for later evaluation of effects on space station experiments. Parametric data on the effects of separation distance on power system mass are presented