Malaria Transmission-Blocking Vaccines: Present Status and Future Perspectives

Transmission-blocking vaccines (TBVs) utilize Plasmodium sexual stage proteins to induce antibodies that prevent parasites from infecting blood-fed mosquitoes. This type of vaccine, which can be considered a “vaccine of solidarity,” reduces Plasmodium infections within communities without conferring direct protective immunity to the vaccine recipients. The leading TBV candidates have advanced to field clinical trials, where vaccine-induced antibody function has been demonstrated in mosquito-feeding assays. However, the duration of functional antibody responses has been short-lived; hence current development has focused on improved adjuvant and vaccine delivery systems to generate long-lasting immune responses. For the future implementation of TBVs, community perceptions and understandings should be considered, and education should be provided on the concept and its value. Implementation will need to be undertaken in harmony with current malaria control policies

Cultivating community economies: tools for building a liveable world

One chapter allowed - 18mth embargoAmid the failure of traditional politics and policies to address our fundamental challenges, an increasing number of thoughtful proposals and real-world models suggest new possibilities, this book convenes an essential conversation about ..

Coupled Fluctuations near Critical Wetting

Recent work on the complete wetting transition has emphasized the role played by the coupling of fluctuations of the order parameter at the wall and at the depinning fluid interface. Extending this approach to the wetting transition itself we predict a novel crossover effect associated with the decoupling of fluctuations as the temperature is lowered towards the transition temperature T_W. Using this we are able to reanalyse recent Monte-Carlo simulation studies and extract a value \omega(T_W)=0.8 at T_W=0.9T_C in very good agreement with long standing theoretical predictions.Comment: 4 pages, LaTex, 1 postscript figur

Patterns in the Kardar-Parisi-Zhang equation

We review a recent asymptotic weak noise approach to the Kardar-Parisi-Zhang equation for the kinetic growth of an interface in higher dimensions. The weak noise approach provides a many body picture of a growing interface in terms of a network of localized growth modes. Scaling in 1d is associated with a gapless domain wall mode. The method also provides an independent argument for the existence of an upper critical dimension.Comment: 8 pages revtex, 4 eps figure

Coupled non-equilibrium growth equations: Self-consistent mode coupling using vertex renormalization

We find that studying the simplest of the coupled non-equilibrium growth equations of Barabasi by self-consistent mode coupling requires the use of dressed vertices. Using the vertex renormalization, we find a roughness exponent which already in the leading order is quite close to the numerical value.Comment: 7 pages, 3 figure

Upper critical dimension, dynamic exponent and scaling functions in the mode-coupling theory for the Kardar-Parisi-Zhang equation

We study the mode-coupling approximation for the KPZ equation in the strong coupling regime. By constructing an ansatz consistent with the asymptotic forms of the correlation and response functions we determine the upper critical dimension d_c=4, and the expansion z=2-(d-4)/4+O((4-d)^2) around d_c. We find the exact z=3/2 value in d=1, and estimate the values 1.62, 1.78 for z, in d=2,3. The result d_c=4 and the expansion around d_c are very robust and can be derived just from a mild assumption on the relative scale on which the response and correlation functions vary as z approaches 2.Comment: RevTex, 4 page

Biomolecules from Macroalgae-Nutritional Profile and Bioactives for Novel Food Product Development

Seaweed is in the spotlight as a promising source of nutrition for humans as the search for sustainable food production systems continues. Seaweed has a well-documented rich nutritional profile containing compounds such as polyphenols, carotenoids and polysaccharides as well as proteins, fatty acids and minerals. Seaweed processing for the extraction of functional ingredients such as alginate, agar, and carrageenan is well-established. Novel pretreatments such as ultrasound assisted extraction or high-pressure processing can be incorporated to more efficiently extract these targeted ingredients. The scope of products that can be created using seaweed are wide ranging: from bread and noodles to yoghurt and milk and even as an ingredient to enhance the nutritional profile and stability of meat products. There are opportunities for food producers in this area to develop novel food products using seaweed. This review paper discusses the unique properties of seaweed as a food, the processes involved in seaweed aquaculture, and the products that can be developed from this marine biomass. Challenges facing the industry such as consumer hesitation around seaweed products, the safety of seaweed, and processing hurdles will also be discussed

On Critical Exponents and the Renormalization of the Coupling Constant in Growth Models with Surface Diffusion

It is shown by the method of renormalized field theory that in contrast to a statement based on a mathematically ill-defined invariance transformation and found in most of the recent publications on growth models with surface diffusion, the coupling constant of these models renormalizes nontrivially. This implies that the widely accepted supposedly exact scaling exponents are to be corrected. A two-loop calculation shows that the corrections are small and these exponents seem to be very good approximations.Comment: 4 pages, revtex, 2 postscript figures, to appear in Phys.Rev.Let