The risk of occurrence of venous thromboembolism according to deciles of total cholesterol variability (landmark analysis).

The risk of occurrence of venous thromboembolism according to deciles of total cholesterol variability (landmark analysis).</p

The risk of venous thromboembolism according to quartiles of total cholesterol variability additionally adjusting the use of lipid lowering agents and mean total cholesterol level.

The risk of venous thromboembolism according to quartiles of total cholesterol variability additionally adjusting the use of lipid lowering agents and mean total cholesterol level.</p

Data_Sheet_1_Better oral hygiene is associated with a reduced risk of cataract: A nationwide cohort study.docx

ObjectiveTo investigate the association of oral health status and oral hygiene behaviors with cataract occurrence longitudinally.Materials and methodsBased on the National Health Screening cohort database of Korea, participants who underwent oral health screening by dentists in 2003 were included. Cataract was defined as two or more claims of disease classification for the International Classification of Diseases-10 (E10.34, E11.34, E12.34, E13.34, E14.34, H25, and H26) with cataract specific treatment or surgery procedure claim codes. The occurrence of cataract was analyzed with Cox proportional hazard model according to the presence of periodontitis and oral health examination findings, including missing teeth, caries, tooth brushing, and dental scaling.ResultsOverall, 103,619 subjects were included. During a median follow-up of 12.2 years, cataract developed in 12,114 (11.7%) participants. Poor oral health status such as the presence of periodontitis (adjusted hazard ratio [HR] 1.08, 95% CI [confidence interval] 0.99–1.17, p = 0.088) and increased number of missing teeth (adjusted HR = 1.74, 95% CI = 1.55–1.96, p ConclusionPeriodontitis and increased number of missing teeth may increase the risk of cataract. However, maintaining good oral hygiene through tooth brushing and dental scaling may reduce the risk of future cataract occurrence. Further studies should be performed to confirm the association between chronic oral inflammation and cataract.</p

Baseline characteristics of subjects according to total cholesterol variability.

Baseline characteristics of subjects according to total cholesterol variability.</p

The risk of the occurrence of venous thromboembolism according to the quartile of total cholesterol variability in men.

The risk of the occurrence of venous thromboembolism according to the quartile of total cholesterol variability in men.</p

The risk of occurrence of intraabdominal venous thromboembolism according to quartiles of total cholesterol variability.

The risk of occurrence of intraabdominal venous thromboembolism according to quartiles of total cholesterol variability.</p

Flow chart showing the participants selection process.

Flow chart showing the participants selection process.</p

The risk of occurrence of deep vein thrombosis according to quartiles of total cholesterol variability.

The risk of occurrence of deep vein thrombosis according to quartiles of total cholesterol variability.</p

The risk for occurrence of venous thromboembolism according to quartiles of total cholesterol variability.

The risk for occurrence of venous thromboembolism according to quartiles of total cholesterol variability.</p

Information about data source.

BackgroundThe effects of total cholesterol (TC) on coagulation and hemostatic systems could contribute to the development of venous thromboembolism (VTE). We investigated this possible association using TC variability.MethodsFrom the Korean NHIS-HEALS database, 1,236,589 participants with health screenings between 2003 and 2008 were included. TC variability was assessed using various parameters, including the coefficient of variation (CV), standard deviation (SD), and variability independent of mean (VIM). Occurrence of VTE was established by identifying at least two medical claims with a diagnostic code including various types of VTE: deep vein thrombosis (DVT) (I80.2–80.3), pulmonary embolism (PE) (I26, I26.0, I26.9), intraabdominal VTE (I81, I82, I82.2–82.3), and other VTE (I82.8–82.9).ResultsThroughout the study’s median follow-up period of 12.4 years (interquartile range 12.2–12.6) years, TC levels were assessed a total of 5,702,800 times. VTE occurred in 11,769 (1.08%) patients (DVT (4,708 (0.43%)), PE (3,109 (0.29%)), intraabdominal VTE (5,215 (0.48%)), and other VTE (4,794, (0.44%)). As a result, there was gradual association was observed between higher TC variability and occurrence of VTE. Multivariable analysis showed that quartile of TC variability using CV showed a positive correlation with the occurrence of VTE (adjusted hazard ratio (the highest versus lowest quartile), 1.14, 95% confidence interval, 1.08–1.20, p ConclusionsIncreased TC variability may be associated with increased VTE risk. This analysis highlights the importance of maintaining stable TC levels to prevent the development of VTE.</div