Investigating Catastrophic Overfitting in Fast Adversarial Training: A Self-fitting Perspective

Although fast adversarial training provides an efficient approach for building robust networks, it may suffer from a serious problem known as catastrophic overfitting (CO), where multi-step robust accuracy suddenly collapses to zero. In this paper, we for the first time decouple single-step adversarial examples into data-information and self-information, which reveals an interesting phenomenon called "self-fitting". Self-fitting, i.e., the network learns the self-information embedded in single-step perturbations, naturally leads to the occurrence of CO. When self-fitting occurs, the network experiences an obvious "channel differentiation" phenomenon that some convolution channels accounting for recognizing self-information become dominant, while others for data-information are suppressed. In this way, the network can only recognize images with sufficient self-information and loses generalization ability to other types of data. Based on self-fitting, we provide new insights into the existing methods to mitigate CO and extend CO to multi-step adversarial training. Our findings reveal a self-learning mechanism in adversarial training and open up new perspectives for suppressing different kinds of information to mitigate CO.Comment: Comment: The camera-ready version (accepted at CVPR Workshop of Adversarial Machine Learning on Computer Vision: Art of Robustness, 2023

PgtE Enzyme of Salmonella enterica Shares the Similar Biological Roles to Plasminogen Activator (Pla) in Interacting With DEC-205 (CD205), and Enhancing Host Dissemination and Infectivity by Yersinia pestis

Yersinia pestis, the cause of plague, is a newly evolved Gram-negative bacterium. Through the acquisition of the plasminogen activator (Pla), Y. pestis gained the means to rapidly disseminate throughout its mammalian hosts. It was suggested that Y. pestis utilizes Pla to interact with the DEC-205 (CD205) receptor on antigen-presenting cells (APCs) to initiate host dissemination and infection. However, the evolutionary origin of Pla has not been fully elucidated. The PgtE enzyme of Salmonella enterica, involved in host dissemination, shows sequence similarity with the Y. pestis Pla. In this study, we demonstrated that both Escherichia coli K-12 and Y. pestis bacteria expressing the PgtE-protein were able to interact with primary alveolar macrophages and DEC-205-transfected CHO cells. The interaction between PgtE-expressing bacteria and DEC-205-expressing transfectants could be inhibited by the application of an anti-DEC-205 antibody. Moreover, PgtE-expressing Y. pestis partially re-gained the ability to promote host dissemination and infection. In conclusion, the DEC-205-PgtE interaction plays a role in promoting the dissemination and infection of Y. pestis, suggesting that Pla and the PgtE of S. enterica might share a common evolutionary origin.Peer reviewe

Transcriptome Analysis of Egg Yolk Sialoglycoprotein on Osteogenic Activity in MC3T3-E1 Cells

In this study, the effects of egg yolk sialoglycoprotein (EYG) on osteogenesis in MC3T3-E1 cells were investigated and the DEGs (differentially expressed genes) were explored by transcriptome analysis. The results found that EYG effectively increased cell proliferation, enhanced ALP activity, promoted the secretion of extracellular matrix protein COL-I and OCN, enhanced bone mineralization activity, exhibiting good osteogenic activity. Further study of the mechanism was explored through transcriptome analysis. Transcriptome analysis showed that 123 DEGs were triggered by EYG, of which 78 genes were downregulated and 45 genes were upregulated. GO (gene ontology) analysis showed that EYG mainly caused differences in gene expression of biological processes and cell composition categories in the top 30 most enriched items. KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis showed that EYG inhibited inflammatory factors and downregulated inflammation-related pathways. The results also showed EYG regulated such genes as COL2A1, COL4A1 and COL4A2 to up-regulate pathways including ECM–receptor interaction, focal adhesion and protein digestion and absorption, enhancing the proliferation and differentiation of osteoblasts. Gene expression of COL-I, Runx2, BMP2 and β-catenin was determined by qRT-PCR for verification, which found that EYG significantly increased COL-I, Runx2, BMP2 and β-catenin gene expression, suggesting that BMP-2 mediated osteogenesis pathway was activated

Neutron capture on

Neutron capture on $$^{16}$$O may serve as a neutron poison in certain nucleosynthesis scenarios. We revisit this reaction at energy ranges of astrophysical interest, employing a novel theoretical approach that self-consistently treats capture through bound and resonant levels. Our covariant density functional theory is based on a relativistic mean field (RMF) theory with contributions from resonant orbitals included via the analytical continuation of the coupling constant (ACCC), and pairing correlations included via the resonant Bardeen–Cooper–Schrieffer (BCS) technique. We employ this RMF + ACCC + BCS approach to extract bound states, resonant states, and pairing correlations in $$^{17}$$O in a self-consistent microscopic way. We calculate $$^{16}$$O(n,$$\gamma$$)$$^{17}$$O direct capture cross sections resulting from neutron E1 transitions from scattering states to bound states, resonant cross sections from a Breit–Wigner formalism, and Maxwellian-averaged cross sections and thermonuclear reaction rates for astrophysical applications. We use different effective interactions to determine the viability of our approach to determine the $$^{17}$$O level structure and corresponding reaction rates. Comparisons to measurements and database values are given

Friction self-piercing riveting (F-SPR) of aluminum alloy to magnesium alloy using a flat die

Friction self-piercing riveting (F-SPR) process based on a pip die has been invented to solve the cracking problems in riveting high-strength and low-ductility light metals, such as magnesium alloys, cast aluminum, and 7 series aluminum alloys. In this paper, in order to solve quality issues caused by the misalignment between rivet and pip-die in F-SPR, a flat-die based F-SPR process was proposed and employed to join 1.27 mm-thick AA6061-T6 to 3 mm-thick AZ31B. The results indicate that a 1.0 mm die distance is effective to avoid rivet upset and insufficient flaring. As the feed rate increases, the heat input in the whole process decreases, resulting in a larger riveting force, which in turn increases both the bottom thickness and interlock amount. Besides, solid-state bonding, including Al-Mg intermetallic compounds (IMCs), Al-Mg mechanical mixture, and Al-Fe atom interdiffusion was observed at the joint interfaces. The upper Al layer was softened, but the lower Mg layer was hardened, and both sheets exhibited a narrowed affected region with the increase of feed rate, while the rivet hardness shows no obvious change. Three fracture modes appeared accompanying the variations in lap-shear strength and energy absorption as the feed rate increased from 2 mm/s to 8 mm/s. Finally, the F-SPR process using a flat die was compared to those using a pip die and a flat bottom die to show the advantage of flat die on coping with the misalignment problem

Research on the behaviour and mechanism of void welding based on multiple scales

As the core foundation of major national equipment, large forgings have a great influence on the national economic construction, the development of national defence equipment and the development of modern cutting-edge science and technology. In the production of large forgings, welding the internal void of forgings is a technical problem that directly affects the quality of large forgings. In view of the phenomenon of void welding in large forgings, the behaviour and mechanism of void welding were deeply studied based on the stretching test and molecular dynamics simulation, combined with a lot of theoretical analysis. The results show that multi-pass stretching deformation is a kind of plastic deformation process which can eliminate void defects. When the forging ratio reaches 2.2, the void can be welded completely and the tensile strength can be restored to the level of the matrix. With the increase of compression deformation, the stress will increase sharply, especially at the grain boundary. In addition, the main void welding mechanism of 30Cr2Ni4MoV steel is the recrystallization and grain growth mechanism. Recrystallization and grain growth are of great significance for promoting the reduction of void volume and realizing metallurgical bonding of the interface