5,309 research outputs found
Comment on "Chiral Suppression of Scalar Glueball Decay"
Comment on ``Chiral Suppression of Scalar Glueball Decay''Comment: Comment published in Phys. Rev. Lett. 98, 149103(2007
Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects.
ObjectiveTo determine the variation of IFN-γ and IL-17 responses to M. tuberculosis antigens in healthy TST+ humans.MethodsWe isolated peripheral blood mononuclear cells from 21 TST+ healthy adults, stimulated them with phytohemagglutinin (PHA), PPD, Ag85B, ESAT-6, and live M. bovis BCG, and assayed IFN-γ and IL-17 secretion by ELISA in supernatants after 24 or 72 hours of incubation respectively.ResultsAs in other studies, we found a wide range of IFN-γ responses to M. tuberculosis antigens; the variation significantly exceeded that observed in the same donors to the polyclonal T cell stimulus, phytohemagglutinin (PHA). In addition, we assayed IL-17 secretion in response to the same stimuli, and found less subject-to-subject variation. Analysis of the ratio of IFN-γ to IL-17 secretion on a subject-to-subject basis also revealed a wide range, with the majority of results distributed in a narrow range, and a minority with extreme results all of which were greater than that in the majority of subjects. The data suggest that study of exceptional responses to M. tuberculosis antigens may reveal immunologic correlates with specific outcomes of M. tuberculosis infection.ConclusionVariation of IFNγ and IFN-γ/IL-17 responses to mycobacterial antigens exceeds that of responses to the polyclonal stimulus, PHA, in TST positive healthy humans. This indicates a quantitative spectrum of human immune responses to infection with M. tuberculosis. Since the outcome of human infection with M. tuberculosis varies greatly, systematic study of multiple immune responses to multiple antigens is likely to reveal correlations between selected immune responses and the outcomes of infection
(Z)-Ethyl 3-(2,4-difluoroanilino)-2-(4-methoxyphenyl)acrylate
The title compound, C18H17F2NO3, consists of three individually planar subunits, namely two benzene rings and one aminoacrylate group. The aminoacrylate group forms dihedral angles of 5.92 (7) and 50.21 (6)° with the difluoro and methoxy benzene rings, respectively. The dihedral angle between the two benzene rings is 55.25 (7)°. The molecules exhibit intramolecular N—H⋯O and N—H⋯F interactions and form a three-dimensional network via intermolecular C—H⋯O and C—H⋯π hydrogen bonds
Flat-band and multi-dimensional fermions in Pb10(PO4)6O4
Employing a combination of first-principles calculations and low-energy
effective models, we present a comprehensive investigation on the electronic
structure of Pb(PO)O, which exhibits remarkable
quasi-one-dimensional flat-band around the Fermi level that contains novel
multi-dimensional fermions. These flat bands predominantly originate from
orbital of the oxygen molecules chain at Wyckoff positions, and
thus can be well-captured by a four-band tight-binding model. Furthermore, the
abundant crystal symmetry inherent to Pb(PO)O provides
an ideal platform for the emergence of various multi-dimensional fermions,
including a 0D four-fold degenerated Dirac fermion with quadratic dispersion, a
1D quadratic/linear nodal-line (QNL/LNL) fermion along symmetric -paths, 1D
hourglass nodal-line (HNL) fermion linked to the Dirac fermion, and a 2D
symmetry-enforced nodal surface (NS) found on the = plane. Moreover,
when considering the weak ferromagnetic order, Pb(PO)O
transforms into a rare semi-half-metal, which is characterized by the presence
of Dirac fermion and HNL fermion at the Fermi level for a single spin channel
exhibiting 100 spin polarization. Our findings reveal the coexistence of
flat bands, diverse topological semimetal states and ferromagnetism within in
Pb(PO)O, which may provide valuable insights for
further exploring intriguing interplay between superconductivity and exotic
electronic states.Comment: 8 pages, 4 figure
Bis(4-aminobenzenesulfonato-κN)diaquabis(dimethylformamide-κO)nickel(II) dihydrate
In the title compound, [Ni(C6H6NO3S)2(C3H7NO)2(H2O)2]·2H2O, the NiII ion (site symmetry ) is coordinated by two –NH2 groups from two 4-aminobenzenesulfonate anions, two O atoms from two dimethylformamide molecules and two water molecules, forming a slightly distorted trans-NiN2O4 octahedral geometry. In the crystal structure, intermolecular O—H⋯O, O—H⋯(O,O) and N—H⋯O hydrogen bonds link the components into a three-dimensional network. The O atoms of the sulfonate group are disordered over two sets of sites in a 0.833 (4):0.167 (4) ratio and the O atom of the uncoordinated water molecule is disordered over two sites in a 0.637 (18):0.363 (18) ratio
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