The Electrically Evoked Compound Action Potential: From Laboratory to Clinic

The electrically evoked compound action potential (eCAP) represents the synchronous firing of a population of electrically stimulated auditory nerve fibers. It can be directly recorded on a surgically exposed nerve trunk in animals or from an intra-cochlear electrode of a cochlear implant. In the past two decades, the eCAP has been widely recorded in both animals and clinical patient populations using different testing paradigms. This paper provides an overview of recording methodologies and response characteristics of the eCAP, as well as its potential applications in research and clinical situations. Relevant studies are reviewed and implications for clinicians are discussed

Temporal Response Properties of the Auditory Nerve in Implanted Children with Auditory Neuropathy Spectrum Disorder and Implanted Children with Sensorineural Hearing Loss

This study aimed to 1) characterize temporal response properties of the auditory nerve in implanted children with auditory neuropathy spectrum disorder (ANSD); and 2) compare results recorded in implanted children with ANSD with those measured in implanted children with sensorineural hearing loss (SNHL)

Auditory discrimination: The relationship between psychophysical and electrophysiological measures

This study aimed to 1) investigate the relationship between the acoustic change complex (ACC) and perceptual measures of frequency and intensity discrimination, and gap detection; and 2) examine the effects of acoustic change on the amplitudes and latencies of the ACC

Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

This study aimed to 1) characterize morphological characteristics of the electrically-evoked cortical auditory event-related potentials (eERP) and explore the potential association between onset eERP morphology and auditory vs non-auditory stimulation; 2) assess test-retest reliability of onset eERPs; 3) investigate effects of stimulation level on onset eERPs; and 4) explore the feasibility of using the onset eERP to estimate the lowest stimulation level that can be detected for individual stimulating electrodes in patients with auditory brainstem implants (ABIs)

Effects of Stimulation Level and Electrode Pairing on the Binaural Interaction Component of the Electrically Evoked Auditory Brain Stem Response

The purpose of this study was to investigate the effects of stimulation level and electrode pairing on the binaural interaction component (BIC) of the electrically evoked auditory brain stem response (EABR) in Nucleus cochlear implant users

Preliminary Results of the Relationship Between the Binaural Interaction Component of the Electrically Evoked Auditory Brainstem Response and Interaural Pitch Comparisons in Bilateral Cochlear Implant Recipients

The purpose of this study was to investigate the relationship between electrophysiologic measures of the binaural interaction component (BIC) of the electrically evoked auditory brainstem response (EABR) and psychophysical measures of interaural pitch comparisons in Nucleus bilateral cochlear implant users

The monaural temporal window based on masking period pattern data in school-aged children and adults

Several lines of evidence indicate that auditory temporal resolution improves over childhood, whereas other data implicate the development of processing efficiency. The present study used the masking period pattern paradigm to examine the maturation of temporal processing in normal-hearing children (4.8 to 10.7 yrs) compared to adults. Thresholds for a brief tone were measured at 6 temporal positions relative to the period of a 5-Hz quasi-square-wave masker envelope, with a 20-dB modulation depth, as well as in 2 steady maskers. The signal was a pure tone at either 1000 or 6500 Hz, and the masker was a band of noise, either spectrally wide or narrow (21.3 and 1.4 equivalent rectangular bandwidths, respectively). Masker modulation improved thresholds more for wide than narrow bandwidths, and adults tended to receive more benefit from modulation than young children. Fits to data for the wide maskers indicated a change in window symmetry with development, reflecting relatively greater backward masking for the youngest listeners. Data for children >6.5 yrs of age appeared more adult-like for the 6500- than the 1000-Hz signal. Differences in temporal window asymmetry with listener age cannot be entirely explained as a consequence of a higher criterion for detection in children, a form of inefficiency

Cochlear Implant–Evoked Cortical Activation in Children With Cochlear Nerve Deficiency

To report the results of cochlear implant-elicited cortical auditory evoked potentials (eCAEP) in children with cochlear nerve deficiency (CND)

Objective Measures of Electrode Discrimination With Electrically Evoked Auditory Change Complex and Speech-Perception Abilities in Children With Auditory Neuropathy Spectrum Disorder

This study aimed to 1) determine the sensitivity of the electrically evoked auditory change complex (eACC) to changes in stimulating electrode position; and 2) investigate the association between results of eACC measures and behavioral electrode discrimination and their association with speech-perception performance in pediatric cochlear implant (CI) users who have auditory neuropathy spectrum disorder (ANSD)

Objective hearing threshold estimation in children with auditory neuropathy spectrum disorder: Electrophysiology and ANSD

, 123:2859–2861, 201