Numerical and Experimental Characterization of Radiation Mode of 45° Tilted Fiber Grating

In this paper, we have numerically and experimentally investigated the radiation mode of 45° tilted fiber grating (45° TFG). By introducing the axial distributions into the volume current method, we have established a three-dimensional theoretical model to analyze spatial distributions of the radiation mode of 45° TFG, and measured the radiation mode spatial distributions in experiment. Both numerical and experimental results show that the radiation mode of 45° TFG exhibits an exponential reduction along the fiber axial direction, and a quasi-Gaussian profile along the radial direction of fiber. Additionally, we have also measured the detailed polarization-dependent azimuthal intensity distributions of radiation modes of both s-and p-polarized core modes. The degree of polarization of radiation mode is around 99.886%, which is independent of the length and the polarization extinction ratio of the grating. Moreover, for the first time, we have experimentally observed a very weak p-polarized component existing in the radiation mode, which has matched well with the simulation results

Compact linear polarization spectrometer based on radiation mode shaped in-fiber diffraction grating

We propose a compact linear polarization spectrometer based on the in-fiber polarization-dependent diffraction grating. The beam profile of radiated light of the grating is shaped to be a Gaussian profile to improve the performance of the spectrometer, where the size of the focused light spot is reduced from 44 um to 33 um with the shaped radiation mode of the grating. Based on the experimental results, the proposed spectrometer can achieve 0.05 nm resolution and 115 nm wavelength responding range from 1495 nm to 1610 nm. To verify the performance of the proposed fiber spectrometer, we measure the transmission spectra of an excessively tilted fiber grating, which has a pair of orthogonal polarization transmission spectra. Compared with the traditional measuring method, the proposed fiber spectrometer integrates the polarizing and spectral analyzing functions in the measuring system and achieves the polarization-sensitive spectral analysis, which shows good wavelength consistency and perfect polarization characteristics

Crustal Structures of the Qimantagh Metallogenic Belt in the Northern Tibetan Plateau from Magnetotelluric Data and Their Correlation to the Distribution of Mineral Deposits

Crustal structure and fluid or melt originating in the deep crust and mantle are critical in regional magmatic mineral systems. However, the crustal structure and the processes that entrain and focus fluids from a deep-source region to a metallogenic belt remain relatively undisclosed. We present a magnetotelluric (MT) study of the eastern Qimantagh Metallogenic Belt (QMB) in the northern Tibetan Plateau. Data from 33 MT stations in two sections and 7 dispersed stations are acquired using a surface electromagnetic prospecting (SEP) system in frequency band ranges from 320 Hz to 0.00034 Hz. Data are converted by Bostick conversion and two-dimensional (2D) nonlinear conjugate gradient inversion. Our MT results reveal the geoelectrical crustal structure of the QMB, which consists of a southern low-resistivity domain that reflects the Kumukuri rift, a high-resistivity middle domain that represents the southern QMB in the central Kunlun belt, and a northern low-resistivity domain that covers the northern QMB and southwestern Qaidam block. We present a comprehensive tectonic and geophysical model of QMB based on the MT interpretation and geological analysis. We infer the high-resistivity domain as a reflection of a rigid crust and detached lithospheric mantle, this belt separate the QMB into northern and southern QMB. Most of the mineral deposits are found in the northern low-resistivity domain of QMB. Our study and findings provide an understanding of the tectonic evolution of the northern Tibetan Plateau, the crustal structure that controls the temporal and spatial distribution of magmatic rocks, and the geological signature associated with mineral deposits

Crustal Structures of the Qimantagh Metallogenic Belt in the Northern Tibetan Plateau from Magnetotelluric Data and Their Correlation to the Distribution of Mineral Deposits

Crustal structure and fluid or melt originating in the deep crust and mantle are critical in regional magmatic mineral systems. However, the crustal structure and the processes that entrain and focus fluids from a deep-source region to a metallogenic belt remain relatively undisclosed. We present a magnetotelluric (MT) study of the eastern Qimantagh Metallogenic Belt (QMB) in the northern Tibetan Plateau. Data from 33 MT stations in two sections and 7 dispersed stations are acquired using a surface electromagnetic prospecting (SEP) system in frequency band ranges from 320 Hz to 0.00034 Hz. Data are converted by Bostick conversion and two-dimensional (2D) nonlinear conjugate gradient inversion. Our MT results reveal the geoelectrical crustal structure of the QMB, which consists of a southern low-resistivity domain that reflects the Kumukuri rift, a high-resistivity middle domain that represents the southern QMB in the central Kunlun belt, and a northern low-resistivity domain that covers the northern QMB and southwestern Qaidam block. We present a comprehensive tectonic and geophysical model of QMB based on the MT interpretation and geological analysis. We infer the high-resistivity domain as a reflection of a rigid crust and detached lithospheric mantle, this belt separate the QMB into northern and southern QMB. Most of the mineral deposits are found in the northern low-resistivity domain of QMB. Our study and findings provide an understanding of the tectonic evolution of the northern Tibetan Plateau, the crustal structure that controls the temporal and spatial distribution of magmatic rocks, and the geological signature associated with mineral deposits

Serial foodborne norovirus outbreaks associated with multiple genotypes.

Noroviruses (NoV) have been recognized as an important pathogen associated with acute gastroenteritis worldwide during the past three decades. In the spring of 2012, a series of foodborne outbreaks in tourist groups were reported to Xiamen Center for Disease Control and Prevention, Xiamen, Fujian province, China. Among a total of 268 tourists in 7 groups, the prevalence rate of acute gastroenteritis was 16.0% (43/268). Twenty-three feces or anal swabs were collected for laboratory tests of causative agents, no bacterial pathogen was identified, while 22 of them were positive for NoV RNA. In addition, thirteen NoV fragments were recovered from positive specimens and sequenced, belonging to five genotypes such as GI.3, GI.4, GII.4, GII.6, and GII.14, respectively. However, NoV fragments obtained from locally infected patients showed distinct genotypes. Therefore, epidemiological investigation and laboratory analyses demonstrated that the serial foodborne NoV outbreaks in tourists were co-infection of multiple genotypes induced acute gastroenteritis linked to a restaurant

Genome-wide analysis reflects novel 5-hydroxymethylcytosines implicated in diabetic nephropathy and the biomarker potential

Aim: Diabetic nephropathy (DN) has become the most common cause of end-stage renal disease in most countries for patients with type 2 diabetes (T2D). Elucidating novel epigenetic contributors to DN can not only enhance our understanding of this complex disorder but also lay the foundation for developing more effective monitoring tools and preventive interventions in the future, thus contributing to our ultimate goal of improving patient care. Methods: 5-hydroxymethylcytosines (5hmC)-Seal, a highly selective chemical labeling technique, was used to profile genome-wide 5hmC, a stable cytosine modification type marking gene activation, in circulating cell-free DNA (cfDNA) samples from a cohort of patients recruited at Zhongnan Hospital, including T2D patients with nephropathy (DN, n = 12), T2D patients with non-DN vascular complications (non-DN, n = 29), and T2D patients without any complication (controls, n = 14). Differential analysis was performed to find DN-associated 5hmC features, followed by the exploration of biomarker potential of 5hmC in cfDNA for DN using a machine learning approach.Results: Genome-wide analyses of 5hmC in cfDNA detected 427 and 336 differential 5hmC modifications associated with DN, compared with non-DN individuals and controls, and suggested relevant pathways such as NOD-like receptor signaling pathway and tyrosine metabolism. Our exploration using a machine learning approach revealed an exploratory model comprised of ten 5hmC genes showing the possibility to distinguish DN from non-DN individuals or controls. Conclusion: Genome-wide analysis suggests the possibility of exploiting novel 5hmC in patient-derived cfDNA as a non-invasive tool for monitoring DN in high-risk T2D patients in the future

Phylogenetic analyses of partial RdRP/VP1 genes in NoV strains associated with serial foodborne outbreaks in tourist groups.

<p>Thirteen strains belonging to five genotypes including GI.3, GI.4, GII.4, GII.6 and GII.14 were detected in 22 specimens from Event A–G., which was associated with infections occurred at the restaurant. One GI.3 strain (labeled with black triangle) was detected in one restaurant employee. Local infections with 4 genotypes (labeled with diamond) such as GI.3, GI.5, GII.6 and GII.12 were identified in 3 patients.</p

Primers for amplification and sequencing of partial RdRP/VP1 gene.

<p>Primers for amplification and sequencing of partial RdRP/VP1 gene.</p

Summary of investigation on NoV acute gastroenteritis outbreaks in tourist groups.

*<p>The exposure date for patients in Event H was between April 15 to April 17, 2012.</p>**<p>indicate anal swabs from employees of the restaurant under investigation.</p

List of positive specimens in NoV RNA detection and their genotypes.

<p>NT, not tested; NA, not available.</p