Correlational Research on Mobile Phone Addiction and the Interpersonal Relationship Distress of Chinese College Students

In this essay, we utilized the following scales: Mobile and Internet Addiction Test, Basic Psychological Needs Scale, Negative Coping Style Questionnaire, and Interpersonal Relationships Assessment Scale. With those, we surveyed 1,730 college students, investigating the influence of mobile phone addiction on their interpersonal relationship distress and the mediating chain effect of basic psychological needs and negative coping styles on mobile phone addiction and interpersonal relationship distress. The results indicate that: (1) Mobile phone addiction can predict interpersonal relationship distress in college students; (2) Basic psychological needs serve as the mediating variables between mobile phone addiction and interpersonal relationship distress; (3) Negative coping styles prove to be the mediator between mobile phone addiction and interpersonal relationship distress; and (4) Basic psychological needs and negative coping styles establish a mediating chain effect between mobile phone addiction and interpersonal relationship distress

Biomedical Applications of Graphene

Graphene exhibits unique 2-D structure and exceptional phyiscal and chemical properties that lead to many potential applications. Among various applications, biomedical applications of graphene have attracted ever-increasing interests over the last three years. In this review, we present an overview of current advances in applications of graphene in biomedicine with focus on drug delivery, cancer therapy and biological imaging, together with a brief discussion on the challenges and perspectives for future research in this field

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Abstract Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor in humans. Despite multimodal therapy, the outcome for patients with GBM is still poor. Therefore, developing novel therapeutic strategy is a critical requirement. Methods We have developed a novel reprogramming method that uses a conceptually unique strategy for GBM treatment. We screened a kinase inhibitor library to find which candidate inhibitors under reprogramming condition can reprogram GBM cells into neurons. The induced neurons are identified whether functional and loss of tumorigenicity. Results We have found that mTOR and ROCK kinase inhibitors are sufficient to reprogram GBM cells into neural-like cells and “normal” neurons. The induced neurons expressed neuron-specific proteins, generated action potentials and neurotransmitter receptor-mediated currents. Genome-wide transcriptional analysis showed that the induced neurons had a profile different from GBM cells and were similar to that of control neurons induced by established methods. In vitro and in vivo tumorigenesis assays showed that induced neurons lost their proliferation ability and tumorigenicity. Moreover, reprogramming treatment with ROCK-mTOR inhibitors prevented GBM local recurrence in mice. Conclusion This study indicates that ROCK and mTOR inhibitors-based reprogramming treatment prevents GBM local recurrence. Currently ROCK-mTOR inhibitors are used as anti-tumor drugs in patients, so this reprogramming strategy has significant potential to move rapidly toward clinical trials

A Systematic Mapping Study on Off-The-Shelf-based Software Acquisition

Acquiring software from external suppliers and developing less software in-house can help software-developing organizations improve operational efficiency by reducing costs, time and reusing current technologies. Software projects increasingly use Off-The-Shelf (OTS) products. From the acquirer perspective, there is a need to understand in more detail OTS-based software acquisition processes, because they are different to and less well-understood than those for the acquisition of custom software. In this paper we have undertaken a systematic mapping study on OTS-based software acquisition. The study compares and contrasts OTS-based software acquisition and non-OTS-based software acquisition, and identifies factors influencing decision making in OTS-based software acquisition. We find that the main difference is that there is a relationship between determining the software requirements and OTS selection in OTS-based software acquisition. For commercial OTS software, the major factors are functionality and quality of the software, but for open-source OTS software, cost was the most important factor

Multiscale Image Representation and Texture Extraction Using Hierarchical Variational Decomposition

In order to achieve a mutiscale representation and texture extraction for textured image, a hierarchical (BV,Gp,L2) decomposition model is proposed in this paper. We firstly introduce the proposed model which is obtained by replacing the fixed scale parameter of the original (BV,Gp,L2) decomposition with a varying sequence. And then, the existence and convergence of the hierarchical decomposition are proved. Furthermore, we show the nontrivial property of this hierarchical decomposition. Finally, we introduce a simple numerical method for the hierarchical decomposition, which utilizes gradient decent for energy minimization and finite difference for the associated gradient flow equations. Numerical results show that the proposed hierarchical (BV,Gp,L2) decomposition is very appropriate for multiscale representation and texture extraction of textured image

Circumferences and minimum degrees in 3-connected claw-free graphs

AbstractIn this paper, we prove that every 3-connected claw-free graph G on n vertices contains a cycle of length at least min{n,6δ−15}, thereby generalizing several known results