Simulation of urban waterlogging with TELEMAC-2D/SWMM coupled model

Hydrodynamic

The evaluation for perceived quality of products based on text mining and fuzzy comprehensive evaluation

Abstract With the growth of the Internet and electronic commerce, more and more customers browse online reviews to understand products and service reputation. Online reviews can provide decision support for customers to purchase a product that is to their satisfaction. Manufacturers can also mine and analyze valuable information in favor of design and production from online reviews. Customer satisfaction is mainly determined by perceived quality of products. Hence, this study establishes a new method to evaluate the perceived quality by combining text mining with a fuzzy comprehensive evaluation method. The new evaluation method offers ideas and methods for future work to combine text mining technology with traditional evaluation methods. Customers can also make better purchase decisions and manufacturers design and manufacture better products by using this evaluation method.Keywords Online shopping review Text mining Fuzzy comprehensive evaluation method Product evaluatio

Boron tin oxide for filterless intrinsic-narrowband solar-blind ultraviolet detectors with tunable photoresponse peak from 231 to 275 nm

Solar-blind ultraviolet (SBUV) detection has a great prospect in a wide range of applications, in which the synthesis of semiconductor materials with a suitable bandgap can be an important research focus. In this work, BSnO films with good selectivity for SBUV were grown by magnetron sputtering with the bandgap adjusted from 4.1 to 5.3 eV. Based on the BSnO films, filter-less narrowband SBUV detectors were fabricated first, exhibiting a narrow detection range and an ultra-high responsivity (113 A/W) required by the detection of extremely weak SBUV signals. In addition, graphene/BSnO/SiC heterojunction photovoltaic detectors were also fabricated, with a high photo-to-dark current ratio and an ultra-fast response exhibited under 0 V bias, confirming their ability to handle the detection of transient signals

Image_1_Research on the relationship between marital commitment, sacrifice behavior and marital quality of military couples.pdf

Based on the actor-partner interdependence model, this paper studied the relationship between marital commitment, sacrifice behavior and marital quality of military couples. A convenience sample of 171 Chinese military couples from Guangdong, Jiangsu and Sichuan province was used. All participants completed the self-report questionnaires independently including the Dimension of Commitment Inventory (DCI), the Couples Sacrifice Behavior Scale (CSBS) and the Evaluation and Nurturing Relationship Issues, Communication and Happiness (ENRICH). Results showed that the scores of marital commitment and marital quality of male soldiers were significantly higher than that of their spouses. Compared to their spouses, male soldiers reported higher frequency of sacrifice behaviors and perceiving sacrifice behaviors of spouses. Furthermore, the marital commitment of military couples had significant influence on their own marital quality and frequency of perceiving each other’s sacrifice behavior Military couples’ perception of the frequency of each other’s sacrifice behavior partially mediated the effect of marital commitment on their marital quality. Male soldiers’ perception of spouse’s sacrifice behavior frequency significantly predicted the marital quality of their spouses.</p

Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1

Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO2-HDL) in promoting re-endothelialization. We demonstrate that 4F and Cl/NO2-HDL act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 (-/-) mouse aortic endothelial cells. Wound healing, transwell migration, lamellipodia formation and single cell migration assay experiments show that 4F treatment is associated with a recovery of endothelial cell migration and associated with significantly increased endothelial nitric oxide synthase (eNOS) activity, Akt phosphorylation and SR-B1 expression. 4F increases NO generation and diminishes oxidative stress. In vivo, 4F can stimulate cell proliferation and re-endothelialization in the carotid artery after treatment with Cl/NO2-HDL in a carotid artery electric injury model but fails to do so in SR-B1(-/-) mice. These findings demonstrate that 4F promotes endothelial cell migration and has a potential therapeutic benefit against early endothelial injury in cardiovascular diseases

Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis

<p>Abstract</p> <p>Background</p> <p>Previous studies suggest that oxidative stress plays an important role in the development of breast cancer. There is a significant inverse relationship between HDL and the risk and mortality of breast cancer. However, it is well known that under conditions of oxidative stress, such as breast cancer, HDL can be oxidatively modifiedand these modifications may have an effect on the functions of HDL. The purpose of this study is to determine the different effects of normal and oxidized (caused by hypochlorite-induced oxidative stress) HDL on breast cancer cell metastasis.</p> <p>Methods</p> <p>Human breast cancer cell lines were treated with normal and hypochlorite-oxidized HDL, and then cell metastasis potency <it>in vivo </it>and the abilities of migration, invasion, adhesion to HUVEC and ECM <it>in vitro </it>were examined. Integrin expression and PKC activity were evaluated, and PKC inhibitor and PKC siRNA was applied.</p> <p>Results</p> <p>We found hypochlorite-oxidized HDL dramatically promotes breast cancer cell pulmonary metastasis (133.4% increase at <it>P </it>< 0.0 l for MDA-MB-231 by mammary fat pad injection; 164.3% increase at <it>P </it>< 0.01 for MCF7 by tail vein injection) and hepatic metastasis (420% increase at <it>P </it>< 0.0 l for MDA-MB-231 by mammary fat pad injection; 1840% fold increase at <it>P </it>< 0.001 for MCF7 by tail vein injection) in nude mice, and stimulates higher cell invasion (85.1% increase at <it>P </it>< 0.00 l for MDA-MB-231; 88.8% increase at <it>P </it>< 0.00 l for MCF7;), TC-HUVEC adhesion (43.4% increase at <it>P </it>< 0.00 l for MDA-MB-231; 35.2% increase at <it>P </it>< 0.00 l for MCF7), and TC-ECM attachment (41.0% increase at <it>P </it>< 0.00 l for MDA-MB-231; 26.7% increase at <it>P </it>< 0.05 for MCF7) <it>in vitro </it>compared with normal HDL. The data also shows that the PKC pathway is involved in the abnormal actions of hypochlorite-oxidized HDL.</p> <p>Conclusions</p> <p>Our study demonstrated that HDL under hypochlorite-induced oxidative stress stimulates breast cancer cell migration, invasion, adhesion to HUVEC and ECM, thereby promoting metastasis of breast cancer. These results suggest that HDL-based treatments should be considered for treatment of breast cancer patients.</p