12 research outputs found
Effect of <i style="">Aerva lanata</i> on calcium oxalate urolithiasis in rats
981-986Calcium oxalate (CaOx) stone was induced in
rats using 0.75% of ethylene glycol in drinking water for 28 days. Ethylene
glycol treated rats showed significant increase in the activities of oxalate
synthesizing enzymes such as glycolic acid oxidase (GAO) in liver and lactate
dehydrogenase (LDH) in liver and kidney. CaOx crystal deposition, as indicated
by increased excretion of stone-forming constituents in urine, such as calcium,
oxalate, uric acid, phosphorus and protein and decreased concentration of
inhibitors, such as citrate and magnesium was observed in ethylene glycol
induced urolithic rats. Histopathological studies also confirmed the deposition
of CaOx crystals. Administration of Aerva
lanata aqueous suspension (2g/kg body wt/dose/day for 28 days) to CaOx
urolithic rats had reduced the oxalate synthesizing enzymes, diminished the
markers of crystal deposition in the kidney. The results of the present study
confirmed that A. lanata can be used
as an curative agent for urolithiasis
in vitro Antioxidant Activity and Total Polyphenolic Content of Cyperus rotundus Rhizomes
In this study, Antioxidant activity of Cyperus rotundus rhizomes extract (CRRE) was evaluveted in a series of in vitro assay involving free radicals and reactive oxygen species and IC50 values were determined. CRRE exhibited its scavenging effect in concentration dependent manner on superoxide anion radicals, hydroxyl radicals, nitric oxide radical, hydrogen peroxide, and property of metal chelating and reducing power. The extract was also studied for lipid peroxidation assay by thiobarbituric acid–reactive substances (TBARS) using young and aged rat brain mitochondria. The extract was also effective in preventing mitochondrial lipid peroxidation induced by FeSO4/ ascorbate in concentration dependent manner. The results obtained in the present study indicate that C. rotundus rhizomes extract can be a potential source of natural antioxidant